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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
81 Results for "
antifolate
" in MedChemExpress (MCE) Product Catalog:
Products (81)
81 Results for "antifolate" in MCE Product Catalog:
Cat. No.: HY-138615A
Synonyms: dTTP sodium hydrate
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Glutamate carboxypeptidase is an endo/exopeptidase targeting folate and antifolate agents. Glutamate carboxypeptidase regulates intracellular folate homeostasis by hydrolyzing γ-polyglutamate chains. Glutamate carboxypeptidase is promising for research of antifolate agents and cancers .
Cat. No.: HY-117791
CAS No.: 1320211-70-8
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(R)-Pralatrexate is the (R)-enantiomer of Pralatrexate (HY-10446). Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor .
Cat. No.: HY-137267
CAS No.: 80576-77-8
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10-Methyl-10-deazaaminopterin is a folate analog and an antifolate. 10-Methyl-10-deazaaminopterin can be used for the research of cancer .
Cat. No.: HY-126878
CAS No.: 78520-72-6
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11-Oxahomoaminopterin shows antifolate activity and inhibits Lactobacillus casei DHFFZ with antimicrobial and antitumor activities .
Cat. No.: HY-121207
CAS No.: 22006-84-4
Synonyms: Pteroylglutamic acid
Research Areas:
Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an antifolate agent. Denopterin is an antimetabolite that has toxic effects on cells and can be used for cancer .
Cat. No.: HY-143408
CAS No.: 65829-22-3
OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains .
Cat. No.: HY-10824A
CAS No.: 648420-92-2
Synonyms: PT523 monoammonium
Research Areas:
Talotrexin monoammonium is the monoammonium salt form of Talotrexin (HY-10824). Talotrexin monoammonium is an analog of Aminopterin (HY-14518), and is a nonpolyglutamatable classic antifolate. Talotrexin monoammonium is a reduced folate carrier (RFC) specific inhibitor and selectively inhibits RFC transport. Talotrexin monoammonium shows antitumor activity by targeting DHFR to inhibit tumor growth .
Cat. No.: HY-10446R
CAS No.: 146464-95-1
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Pralatrexate (Standard) is the analytical standard of Pralatrexate. This product is intended for research and analytical applications. Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a Ki of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment . Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-14523
CAS No.: 135503-67-2
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LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.
Cat. No.: HY-120293
CAS No.: 145788-82-5
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CB30900 is an inhibitor for thymidylate synthase with an IC50 of 0.2 μM. CB30900 exhibits cytotoxicity in W1L2 with an IC50 of 0.13 μM .
Cat. No.: HY-118251
CAS No.: 123685-36-9
Research Areas:
PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.
Cat. No.: HY-105934A
CAS No.: 52386-42-2
Synonyms: Emofolin sodium; 5-methyltetrahydrohomofolate sodium; NSC 139490 sodium
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Ketotrexate sodium is an orally active antifolate and immunosuppressant. Ketotrexate sodium has good anti-inflammatory activity and is widely used in rheumatoid arthritis (RA). Ketotrexate sodium is used in research into cancer and autoimmune diseases .
Cat. No.: HY-10820S
CAS No.: 1129408-57-6
Synonyms: LY231514-d5
Cat. No.: HY-10820AS
Synonyms: LY231514-d5 disodium
Cat. No.: HY-14519S1
Purity: 99.69%
Cat. No.: HY-130569S
Cat. No.: HY-130569S1
CAS No.: 432545-62-5
Cat. No.: HY-154807
CAS No.: 57343-54-1
DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively .
Cat. No.: HY-130569S2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
