1. Cell Cycle/DNA Damage
  2. Antifolate
  3. LY 254155

LY 254155 

Cat. No.: HY-14523
Handling Instructions

LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.

For research use only. We do not sell to patients.

LY 254155 Chemical Structure

LY 254155 Chemical Structure

CAS No. : 135503-67-2

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LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.

IC50 & Target

Ki: 2.1±0.2 (hGARFT ), 1.7± 0.1 nM (mFBP)[1]

In Vitro

LY 254155 inhibits recombinant human monofunctional glycinamide ribonucleotide formyltransferase (hGARFT) and binds to membrane folate-binding protein (mFBP) [1].

In Vivo

LY 254155 is active against a broad panel of murine and human xenograft solid tumors. LY 254155 (5, 10, 20, and 40 mg/kg) inhibits murine C3H carcinoma growth in C3H mice, with % inhibition of tumor growth is 49%, 71%, 90%, and 94%, respectively[1].

Molecular Weight







O=C1C2=C(NCC(CCC(S3)=CC=C3C(N[[email protected]@H](CCC(O)=O)C(O)=O)=O)C2)N=C(N)N1


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration

C3H mice are used. LY 254155 is dosed on days 1, 4, 7, and 10 (4 treatment days). Cumulative dose is calculated using the formula (daily dose×number of treatment days). Doses are administered in mg of LY 254155 per kg of mouse weight (5, 10, 20, and 40 mg/kg), and 10 mice are inoculated at each dosing level, including a no-compound control group. % inhibition of tumor growth is calculated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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LY 254155LY254155LY-254155AntifolateInhibitorinhibitorinhibit

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