LY 254155

Cat. No.: HY-14523: FAQs
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LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with K_is of 2.1±0.2 and 1.7±0.1 nM, respectively.

For research use only. We do not sell to patients.

LY 254155 Chemical Structure

CAS No. : 135503-67-2

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Description	LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with K_is of 2.1±0.2 and 1.7±0.1 nM, respectively.
IC₅₀ & Target	Ki: 2.1±0.2 (hGARFT ), 1.7± 0.1 nM (mFBP)^[1]
In Vitro	LY 254155 inhibits recombinant human monofunctional glycinamide ribonucleotide formyltransferase (hGARFT) and binds to membrane folate-binding protein (mFBP) ^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. LY 254155 Related Antibodies
In Vivo	LY 254155 is active against a broad panel of murine and human xenograft solid tumors. LY 254155 (5, 10, 20, and 40 mg/kg) inhibits murine C3H carcinoma growth in C3H mice, with % inhibition of tumor growth is 49%, 71%, 90%, and 94%, respectively^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	449.48
Formula	C₁₉H₂₃N₅O₆S
CAS No.	135503-67-2
SMILES	O=C1C2=C(NCC(CCC(S3)=CC=C3C(N[C@@H](CCC(O)=O)C(O)=O)=O)C2)N=C(N)N1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Habeck LL, et al. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of humanglycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res. 1994 Feb 15;54(4):1021-6. [Content Brief]

Animal Administration
^[1]

Mice^[1]
C3H mice are used. LY 254155 is dosed on days 1, 4, 7, and 10 (4 treatment days). Cumulative dose is calculated using the formula (daily dose×number of treatment days). Doses are administered in mg of LY 254155 per kg of mouse weight (5, 10, 20, and 40 mg/kg), and 10 mice are inoculated at each dosing level, including a no-compound control group. % inhibition of tumor growth is calculated^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Habeck LL, et al. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of humanglycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res. 1994 Feb 15;54(4):1021-6. [Content Brief]

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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LY 254155135503-67-2LY254155LY-254155AntifolateInhibitorinhibitorinhibit

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LY 254155

LY 254155 Related Antibodies

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