LY 254155
Based on 1 publication(s) in Google Scholar
LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 135503-67-2
- Formula: C19H23N5O6S
- Molecular Weight:449.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) LY 254155
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Biological Activity
Ki: 2.1±0.2 (hGARFT ), 1.7± 0.1 nM (mFBP)[1]
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Cell Line
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Type | Value | Description | References |
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| CCRF-CEM | IC50 |
2.3 nM
Compound: 11
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In vitro antitumor activity was assessed from rate of cell growth of CCRF/CEM cell line
In vitro antitumor activity was assessed from rate of cell growth of CCRF/CEM cell line
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[PMID: 8027993] |
LY 254155 inhibits recombinant human monofunctional glycinamide ribonucleotide formyltransferase (hGARFT) and binds to membrane folate-binding protein (mFBP) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 135503-67-2
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Molecular Weight 449.48
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Formula C19H23N5O6S
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SMILES
O=C1C2=C(NCC(CCC(S3)=CC=C3C(N[C@@H](CCC(O)=O)C(O)=O)=O)C2)N=C(N)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Astragaloside IV alleviates LPS-induced acute lung injury by regulating receptor C5aR1 and macrophage pyroptosis. [Abstract]2025 Sep 23:162:115176. PMID: 40618503
Protocol
Mice[1]
C3H mice are used. LY 254155 is dosed on days 1, 4, 7, and 10 (4 treatment days). Cumulative dose is calculated using the formula (daily dose×number of treatment days). Doses are administered in mg of LY 254155 per kg of mouse weight (5, 10, 20, and 40 mg/kg), and 10 mice are inoculated at each dosing level, including a no-compound control group. % inhibition of tumor growth is calculated[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY 254155 Related Classifications
HY-14523 Related Classifications
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