123685-36-9
123685-36-9
Chemical Structure
PD130883
- CAS No.: 123685-36-9
- Formula:C18H15N5O3
- Molecular Weight:349.34
IUPAC Name: 2-amino-6-(((4-nitrophenyl)(prop-2-yn-1-yl)amino)methyl)quinazolin-4(3H)-one
InChIKey: MNUZJESDLXCPRG-UHFFFAOYSA-N
SMILES: O=C1NC(N)=NC2=C1C=C(C=C2)CN(CC#C)C3=CC=C(C=C3)[N+]([O-])=O
Biological Activity: PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.
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PD130883 | PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate. | |||||||||||||||||||||
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