65829-22-3
65829-22-3
Chemical Structure
OYYF-175
- CAS. Nr.: 65829-22-3
- Formula:C17H14FN5
- Molecular Weight:307.32
IUPAC Name: 7-(2-fluorobenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine
InChIKey: HAPAUTSWUJUYGK-UHFFFAOYSA-N
SMILES: NC1=C2C3=C(N(CC4=CC=CC=C4F)C=C3)C=CC2=NC(N)=N1
Biological Activity: OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains[1].
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OYYF-175 | OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains. | |||||||||||||||||||||
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References
Keywords
