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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
120 Results for "
db/db
" in MedChemExpress (MCE) Product Catalog:
Products (120)
120 Results for "db/db" in MCE Product Catalog:
Cat. No.: HY-124244
CAS No.: 1257641-15-8
Synonyms: PPARδ/γ agonist 1
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DB-959 (PPARδ/γ agonist 1) is a potent PPAR agonist targeting PPARδ/γ. DB-959 improves spatial learning and memory in mice induced by Streptozotocin (HY-13753) and has the potential to improve Alzheimer's disease (AD). .
Cat. No.: HY-176367
CAS No.: 2769753-52-6
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Multi kinase ligand 4 is a target protein ligand used in the synthesis of PROTAC DB-0646 (HY-137343) .
Cat. No.: HY-172344
CAS No.: 3078748-21-4
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DB-lipidoid 11-10-8 is an ionizable cationic lipid (pKa = 6.22). DB-lipidoid 11-10-8 can be used in lipid nanoparticle (LNP) studies for in vivo delivery of mRNA .
Cat. No.: HY-P5966
CAS No.: 507233-87-6
Synonyms: MOG (40-54)
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Cat. No.: HY-173344
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DB-10 is a pro-agent of 3-nbutylphthalide (NBP) (HY-B0647). DB-10 has significantly high uptake ability via pyrilamine cationic transporters in the temperature and energy dependent manner in cells. DB-10 improves the survival rate of cells. DB-10 could rapidly convert into active original agent and increase the accumulation in the brain in vivo. DB-10 can be used for ischemic stroke study .
Cat. No.: HY-N9186
CAS No.: 226711-23-5
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DB04760 analog 1 is an analogue of DB04760.
Cat. No.: HY-124629A
CAS No.: 2170606-75-2
DB2313 tetrahydrochloride is a potent transcription factor PU.1 inhibitor with an apoptosis of 14 nM. DB2313 tetrahydrochloride disrupts the interaction of PU.1 with target gene promoters. DB2313 tetrahydrochloride induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects .
Cat. No.: HY-114621B
CAS No.: 433735-90-1
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DB772 free base is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 free base also has anti-prion activity .
Cat. No.: HY-14932A
CAS No.: 837369-26-3
Synonyms: db289 maleate
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Pafuramidine (maleate) (DB289 (maleate)) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine (maleate) (DB289 (maleate)) is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria .
Cat. No.: HY-111074
CAS No.: 934017-32-0
Synonyms: MK-0767 analog
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DB12055 (MK-0767 analog) is a covalent SARS-CoV-2 3CL protease inhibitor. DB12055 has the potential for the study of dyslipidemia and diabetes mellitus .
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DH-8P-DB is an anticancer candidate and exhibits cytotoxicity against colon cancer cells .
Cat. No.: HY-P10010
CAS No.: 1623027-80-4
Cat. No.: HY-P5505
CAS No.: 474105-11-8
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Cat. No.: HY-100819
CAS No.: 1365266-79-0
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RO5234444 is an orally active CCR2 antagonist, with IC50s of 22nM for human CCR2 and 161 nM for mouse CCR2. RO5234444 alleviates glomerulosclerosis, reduces albuminuria, and significantly improves the glomerular filtration rate (GFR) in the uninephrectomized (1K) type 2 diabetic db/db mouse model. RO5234444 can be used for the study of type 2 diabetic nephropathy .
Cat. No.: HY-117749
CAS No.: 14008-48-1
Synonyms: WY 8138; db09219 acetate
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Bisoxatin (WY 8138; DB09219) acetate is a laxative agent. Bisoxatin acetate is a stimulant for intestinal peristalsis and has the potential for the research of constipation disorder .
Cat. No.: HY-17538A
CAS No.: 2319647-97-5
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ZLN005 (hydrochloride) is a peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1α) activator. ZLN005 (hydrochloride) can stimulate the expression of PGC-1α and downstream genes in skeletal muscle cells, improve glucose utilization and fatty acid oxidation. ZLN005 (hydrochloride) can increase the transcription of PGC-1α and downstream genes in skeletal muscle of diabetic db/db mice, increase fat oxidation and improve glucose tolerance, pyruvate tolerance and insulin sensitivity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
