14008-48-1
Chemical Structure
Bisoxatin acetate
Synonym(s): WY 8138; DB09219 acetate
- CAS No.: 14008-48-1
- Formula:C24H19NO6
- Molecular Weight:417.41
IUPAC Name: (3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-2,2-diyl)bis(4,1-phenylene) diacetate
InChIKey: ZCBJDQBSLZREAA-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(C=C2)OC(C)=O)(OC3=CC=CC=C3N1)C4=CC=C(C=C4)OC(C)=O
Biological Activity: Bisoxatin (WY 8138; DB09219) acetate is a laxative agent. Bisoxatin acetate is a stimulant for intestinal peristalsis and has the potential for the research of constipation disorder[1]. Bisoxatin binds substantially at the S-protein-ACE2 interface. Bisoxatin has the potential for inhibiting SARS-CoV-2 entry into the host research[2].
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Bisoxatin acetate | 98.41% | Bisoxatin (WY 8138; DB09219) acetate is a laxative agent. Bisoxatin acetate is a stimulant for intestinal peristalsis and has the potential for the research of constipation disorder. Bisoxatin binds substantially at the S-protein-ACE2 interface. Bisoxatin has the potential for inhibiting SARS-CoV-2 entry into the host research. | ||||||||||||||||||||
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References
- [1]. Rider JA. Treatment of acute and chronic constipation with bisoxatin acetate and bisacodyl. Double-blind crossover study. Curr Ther Res Clin Exp. 1971 Jun;13(6):386-92. [Content Brief]
- [2]. Unni S, Aouti S, Thiyagarajan S, Padmanabhan B. Identification of a repurposed drug as an inhibitor of Spike protein of human coronavirus SARS-CoV-2 by computational methods. J Biosci. 2020;45(1):130. [Content Brief]