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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
68 Results for "
eIF4e
" in MedChemExpress (MCE) Product Catalog:
Products (68)
68 Results for "eIF4e" in MCE Product Catalog:
製品番号: HY-168326
CAS 番号: 1139263-21-0
Target:
研究分野:
Antiproliferative agent-64 (Compound 76) is an inhibitor for eukaryotic translation initiation factor 4E (eIF4E), that block the secondary structure of mRNA, thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5' untranslated region (5'UTR) of c-Myc (c-myc 5'UTR) with an EC50 of 1.2 nM, inhibits 5'UTR encoding tubulin (tub 5'UTR) with an EC50 of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC50 of 7 nM .
製品番号: HY-119271A
CAS 番号: 2240186-24-5
別名: (-)-SDS-1-021
(-)-CMLD010509 ((-)-SDS-1-021) is an isomer of CMLD010509 (SDS-1-021) (HY-119271). CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism .
製品番号: HY-184004
研究分野:
NUCC-0231068 is a MNK1 and MNK2 inhibitor with IC50 values of 8 nM and 7 nM, respectively. NUCC-0231068 inhibits the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209, with an IC50 of 23 nM in its purified form and 17 nM in its D2B form. NUCC-0231068 can be used in studies related to glioblastoma .
製品番号: HY-16366A
CAS 番号: 865784-01-6
別名: ON 014185 sodium
Briciclib (ON 014185) sodium is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib sodium exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib sodium reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib sodium can be used for the study of hematological system tumors and solid tumors .
製品番号: HY-P703422
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: eIF4e; eIF-4F 25 KDa Subunit; Prev. eIF4eL1; Eukaryotic Translation Initiation Factor 4e-Like 1; Prev. eIF4F; AUTS19; eIF4e1; CBP; MRNA Cap-Binding Protein; Eukaryotic Translation Initiation Factor 4e; eIF-4e
Species:
Human
Source:
E. coli
製品番号: HY-100733R
CAS 番号: 432499-63-3
研究分野:
4E2RCat (Standard) is the analytical standard of 4E2RCat (HY-100733). This product is intended for research and analytical applications. 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
製品番号: HY-182939
研究分野:
MNK1/2-IN-10 is an orally active, selective MNK1/MNK2 inhibitor, with an IC50 of 10.84 nM for MNK1 and an IC50 of 12.81 nM for MNK2. MNK1/2-IN-10 inhibits eIF4E phosphorylation, the NF-κB signaling pathway, macrophage polarization, oxidative stress and the production of pro-inflammatory cytokines. MNK1/2-IN-10 alleviates kidney and spleen damage in LPS (HY-D1056)-induced inflammatory mouse models. Anti-inflammatory agent 115 is applicable for research related to acute inflammation .
製品番号: HY-182957
CAS 番号: 3081482-46-1
MNK/PIM-IN-2 is a Mnk/Pim kinase inhibitor with an IC50 of 32 nM for Mnk1, 3 nM for Mnk2, and 37 nM for Pim1. MNK/PIM-IN-2 reduces the levels of p-eIF4E and p-4EBP1. MNK/PIM-IN-2 induces cell cycle arrest, apoptosis (apoptosis) and exerts antiproliferative effects in leukemia cells. MNK/PIM-IN-2 can be used in studies related to leukemia .
製品番号: HY-139098A
CAS 番号: 75252-12-9
別名: m7Gp3G ammonium
Target:
研究分野:
7-Methyl-diguanosine triphosphate (m7Gp3G) ammonium is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate ammonium binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate ammonium can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .
製品番号: HY-182046
CAS 番号: 2930131-74-9
研究分野:
HD202A is an orally active, selective dual inhibitor of MNK1/MNK2 (with IC50 values of 6.09 nM and 8.06 nM, and Kd values of 1.913 μM and 5.244 μM, respectively) that inhibits the MNK-eIF4E signaling pathway. By downregulating perilipin 2 and SCD1, while upregulating adipose triglyceride lipase and PPARγ coactivator 1α, HD202A enhances mitochondrial fatty acid oxidation and redox homeostasis. HD202A effectively suppresses body weight gain, hepatic lipid accumulation and elevation of serum lipids, significantly improves glucose tolerance and insulin sensitivity of the organism, and ameliorates inflammatory features. With these comprehensive pharmacological activities, HD202A exhibits great application potential in studies of metabolic dysfunction-associated steatotic liver disease .
製品番号: HY-182704
CAS 番号: 832680-32-7
別名: SBI-1275844
研究分野:
SBI-5844 (SBI-1275844) is a eIF4F complex inhibitor and antiviral agent. SBI-5844 disrupts the assembly of the eIF4F complex and blocks the interaction between eIF4E and eIF4G. SBI-5844 inhibits the synthesis of HCoV-OC43 nucleocapsid protein and reduces the levels of HCoV-OC43 RNA and total protein. SBI-5844 can be used in studies related to human coronavirus OC43 (HCoV-OC43) infection .
製品番号: HY-P85623
別名: 4e BP3; 4e-BP3; 4eBP3; eIF4e binding protein 3; Eukaryotic initiation factor 4e binding protein 3; Eukaryotic translation initiation factor 4e binding protein 3; OTTHUMP00000159879.
製品番号: HY-P85622
別名: 4e-BP2; 4eBP2; 4eBP2_HUMAN; eIF4e binding protein 2; eIF4e-binding protein 2; eIF4ebp2; Eukaryotic translation initiation factor 4e binding protein 1; Eukaryotic translation initiation factor 4e-binding protein 2; PHASII; phosphorylated, heat and acid stable regulated by insulin protein II.
製品番号: HY-145974AGL
CAS 番号: 3080642-79-8
別名: m7G(5')ppp(5')(2'OMeA)pG solution (100 mM) (GMP like)
研究分野:
m7GpppAmpG ammonium solution (100 mM) (GMP-like) (m7G(5')ppp(5')(2'OMeA)pG solution (100 mM) (GMP-like)) is a GMP-like grade of m7GpppAmpG ammonium. m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research .
製品番号: HY-178672A
別名: Anti-Reverse cap analog triammonium solution (100 mM); m2 7,3′O GpppG triammonium solution (100 mM)
Target:
ARCA (triammonium) solution (100 mM) (Anti-Reverse cap analog triammonium solution (100 mM); m2 7,3'OGppp triammonium solution (100 mM)) is a 5′-cap analog. ARCA (triammonium) solution (100 mM) carries a methyl group at the 3'-OH position of m7G, which ensures that the cap is ligated to the 5' end of mRNA in the correct orientation during in vitro transcription and prevents reverse ligation. ARCA (triammonium) solution (100 mM) enhances the translation efficiency and stability of mRNA. In human immature dendritic cells, both the translation efficiency and total protein expression of ARCA (triammonium) solution (100 mM)-capped mRNA are higher than those of conventional m7GpppG-capped mRNA. ARCA (triammonium) solution (100 mM) can be used in research related to cancer, infectious diseases and mRNA vaccines .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
