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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
174 Results for "
DPP-4
" in MedChemExpress (MCE) Product Catalog:
Products (174)
174 Results for "DPP-4" in MCE Product Catalog:
Target:
Áreas de investigación:
N-Boc-Sitagliptin is an intermediate in the synthesis of the dipeptidyl peptidase 4 (DPP-4) inhibitor Sitagliptin (HY-13749).
Referencia número: HY-W003592A
No. CAS: 42538-31-8
Target:
Áreas de investigación:
L-Orinithine lactam hydrochloride is a synthetic intermediate. L-Orinithine lactam (hydrochloride) can be used in the synthesis of dipeptidyl peptidase 4 (DPP-4) inhibitors, as well as signaling peptides .
Referencia número: HY-13749C
No. CAS: 823817-58-9
Synonyms: (S)-MK-0431 phosphate
Target:
Áreas de investigación:
(S)-Sitagliptin phosphate is the less active S-enantiomer of Sitagliptin phosphate. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts .
Referencia número: HY-RS03964
Target:
Áreas de investigación:
Dpp4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dpp4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-155027
Áreas de investigación:
DPP-4-IN-8 (compound 27) is a potent and selective DPP4 (dipeptidyl peptidase 4) inhibitor, with a Ki of 0.96 μM. DPP-4-IN-8 blocks the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells. DPP-4-IN-8 also dose-dependently suppresses the expression levels of the chemokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) .
Referencia número: HY-Z1764
No. CAS: 486460-31-5
Synonyms: Sitagliptin impurity 3
Target:
Áreas de investigación:
DPP-4-IN-18 (Sitagliptin impurity 3) (Compound 4) impurity 3 is a potent, selective and orally active DPP-4 inhibitor with an IC50 of 27 nM. DPP-4-IN-18 can effectively prevent DPP-4 from degrading glucagon-like peptide 1 (GLP-1), thereby increasing the level of active GLP-1. DPP-4-IN-18 can be used for the research of type 2 diabetes .
Referencia número: HY-RS03963
Target:
Áreas de investigación:
DPP4 Human Pre-designed siRNA Set A contains three designed siRNAs for DPP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS03965
Target:
Áreas de investigación:
Dpp4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dpp4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-A0023AR
No. CAS: 850649-61-5
Synonyms: SYR-322 free base (Standard)
Áreas de investigación:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Alogliptin (Standard) is the analytical standard of Alogliptin. This product is intended for research and analytical applications. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes .
Referencia número: HY-146455
No. CAS: 2402735-14-0
Áreas de investigación:
DPP-4-IN-3 (Compound 5a) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 0.75 nM. DPP-4-IN-3 shows excellent antioxidant and insulinotropic activity .
Referencia número: HY-146469
No. CAS: 2010927-65-6
Target:
Áreas de investigación:
DPP-4/GPR119 modulator 2 (Compound 20i) is a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist with an IC50 of 0.22 μM for DPP-IV and an EC50 of 0.95 μM for GPR119. DPP-4/GPR119 modulator 2 can be used for diabetes research . DPP-4/GPR119 modulator 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Referencia número: HY-157390
No. CAS: 2906243-39-6
Target:
Áreas de investigación:
DPP-4-IN-9 (compound 6l) is a potent inhibitor of dipeptidyl peptidase DPP-4 (IC50: 8.22 nM). DPP-4-IN-9 has antihyperglycemic activity .
Referencia número: HY-14806R
No. CAS: 760937-92-6
Synonyms: MP-513 (Standard)
Áreas de investigación:
Teneligliptin (Standard) is the analytical standard of Teneligliptin. This product is intended for research and analytical applications. Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM .
Referencia número: HY-14892B
No. CAS: 1375415-82-9
Synonyms: LC15-0444 tartrate hydrate
Target:
Áreas de investigación:
Gemigliptin (LC15-0444 ) tartrate hydrate is a selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate hydrate exhibits potent anti-glycation properties. Gemigliptin tartrate hydrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications .
Referencia número: HY-174832
Target:
Áreas de investigación:
DPP-4-IN-16 (Compound 92) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor (IC50=0.8 nM). DPP-4-IN-16 inhibits DPP-4-mediated degradation of incretins (e.g., GLP-1 and GIP) to promote insulin secretion and reduce blood glucose. DPP-4-IN-16 is promising for research of type 2 diabetes .
Referencia número: HY-10284R
No. CAS: 668270-12-0
Synonyms: BI 1356 (Standard)
Áreas de investigación:
Linagliptin (Standard) is the analytical standard of Linagliptin. This product is intended for research and analytical applications. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
Referencia número: HY-110051
No. CAS: 866396-70-5
Áreas de investigación:
DPP4-In (hydrochloride) is an inhibitor of dipeptidyl peptidase 4 (DPP4) that can reduce DPP4 expression .
Referencia número: HY-103432
No. CAS: 866396-34-1
Target:
Áreas de investigación:
DPP4-In is an active compound.
Referencia número: HY-170657
Target:
Áreas de investigación:
DPP-4-IN-14 (compound 30) is a DPP-4 inhibitor, with an IC50 of 12.82 nM .
Referencia número: HY-169110
Target:
Áreas de investigación:
DPP-4-IN-12 (compound 46) is a potent DPP-4 inhibitor with IC50 value of 2 nM. DPP-4-IN-12 can be used in the study of type 2 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
