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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
171 Results for "
DPP-4
" in MedChemExpress (MCE) Product Catalog:
Products (171)
171 Results for "DPP-4" in MCE Product Catalog:
Cat. No.: HY-176000
CAS No.: 307345-51-3
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Sulphostin is a covalent inhibitor of dipeptidyl peptidase 4 (DPP4), dipeptidyl peptidase 9 (DPP9), and dipeptidyl peptidase 8 (DPP8) with IC50 values of 79, 1392, 6930 nM, respectively. Sulphostin causes phosphosulfamate modification, irreversibly inhibits the enzyme activity. Sulphostin can be used for inflammation and cancer study .
Synonyms: GLP-1-Gly8; GLP-1 (7-36) analog
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Cat. No.: HY-108795A
Purity: 99.12%
Synonyms: GLP-1-Gly8 TFA; GLP-1 (7-36) analog TFA
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Cat. No.: HY-P6177
CAS No.: 855790-98-6
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Cat. No.: HY-117985
CAS No.: 1222102-29-5
Synonyms: DA-1229
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Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation [4].
Cat. No.: HY-132489S1
CAS No.: 2749855-96-5
Synonyms: (Rac)-MK-0431-d4-1 hydrochloride
Cat. No.: HY-167680
CAS No.: 483369-58-0
Synonyms: GSK823093
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Denagliptin (GSK823093) is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor with activity for the suppression of endocrine and metabolic diseases. Denagliptin can be used to study type 2 diabetes. Denagliptin is stable in the solid state but degrades in solution and in mixtures with various excipients. Denagliptin also exhibits degradation in capsules, mainly through cyclization reactions to form (3S,7S,8aS) aminoamines to provide further synthetic materials. The degradation pathway of Denagliptin was elucidated, providing data to support its formulation development and regulatory filings .
Cat. No.: HY-P9806
Synonyms: MERS-D12; MERS Antibody-D12
Cat. No.: HY-158315
Purity: 99.43%
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NZ-97 is a locally deliverable, lung-retaining dipeptidyl peptidase 4 (DPP4) inhibitor with an IC50 of 18 nM. It exhibits selectivity for DPP8 and DPP9 (with IC50 values of 1.3 μM and 0.6 μM, respectively). NZ-97 inhibits the DPP4 pool in lung-resident cells and epithelial lining fluid, elevates IL-6 and IGF-1 levels, and induces the expansion of type 2 alveolar epithelial cells (AEC2). NZ-97 reduces protein content in bronchoalveolar lavage fluid (BALF), ameliorates lung injury and alleviates pulmonary fibrosis. NZ-97 shows tolerability in untreated Mus musculus mice after intratracheal administration, and does not alter the proliferation or differentiation of lung fibroblasts. NZ-97 can be used in studies related to idiopathic pulmonary fibrosis, acute lung injury and emphysema .
Cat. No.: HY-P72976
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DPP4; DPP IV; Prev. ADCP2; TP103; Prev. CD26; Post-Proline Dipeptidyl Aminopeptidase IV; Adenosine Deaminase Complexing Protein 2; Xaa-Pro-Dipeptidylaminopeptidase; T-Cell Activation Antigen CD26; Gly-Pro Naphthylamidase; Dipeptidyl Peptidase IV; Dipeptidyl-Peptidase IV; DPPIV; Dipeptidyl-Peptidase 4; Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2); Dipeptidylpeptidase 4; ADCP-2; CD26 Antigen; Dipeptidyl Peptidase 4; ADABP
Species:
Human
Source:
HEK293
Cat. No.: HY-N8134
CAS No.: 1809980-25-3
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Cat. No.: HY-13749CR
CAS No.: 823817-58-9
Synonyms: (S)-MK-0431 phosphate (Standard)
(S)-Sitagliptin phosphate (Standard) ((S)-MK-0431 phosphate (Standard)) is the analytical standard of (S)-Sitagliptin (phosphate) (HY-13749C). This product is intended for research and analytical applications. (S)-Sitagliptin phosphate ((S)-MK-0431 phosphate) is the S-isomer of Sitagliptin phosphate (HY-13749A). Sitagliptin phosphate (MK-0431 phosphate) is a potent DPP4 inhibitor. (S)-Sitagliptin phosphate can be used in diabetes research .
Cat. No.: HY-171454
CAS No.: 1914136-10-9
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DA-1241 is a GPR119 agonist. DA-1241 reduces macrophage differentiation through downregulation of NFκB signaling by activating GPR119. DA-1241, alone and in combination with a DPP4 inhibitor, reduces liver inflammation and restores inflammation-related liver gene expression. DA-1241 can be used for the research of metabolic dysfunction-associated steatohepatitis (MASH) .
Cat. No.: HY-P991445
Cat. No.: HY-N9725
CAS No.: 141979-19-3
Synonyms: 16ξ-Hydroxycleroda-3,13-dien-15,16-olide
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16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy .
Cat. No.: HY-117985S
Synonyms: DA-1229-d9
Cat. No.: HY-180527
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SGLT2-IN-5 (Compound 99) is an orally active SGLT2 inhibitor with IC₅₀ values for SGLT2, SGLT1, and DPP4 of 0.8, 23, and 58 nM respectively. SGLT2-IN-5 controls blood sugar levels in diabetic rat models and increases the levels of active GLP-1. SGLT2-IN-5 can be used for the study of type 2 diabetes .
Cat. No.: HY-180528
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SGLT2-IN-6 (Compound 101) is an orally active SGLT2 inhibitor with IC₅₀ values for SGLT2, SGLT1, and DPP4 of 0.8, 6.7, and 72 nM respectively. SGLT2-IN-6 controls blood sugar levels in diabetic rat models and increases the levels of active GLP-1. SGLT2-IN-6 can be used for the study of type 2 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
