517-44-2
Chemical Structure
Sennidin B
- CAS No.: 517-44-2
- Formula:C30H18O10
- Molecular Weight:538.46
IUPAC Name: (9R,9'S)-4,4',5,5'-tetrahydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-[9,9'-bianthracene]-2,2'-dicarboxylic acid
InChIKey: JPMRHWLJLNKRTJ-SZPZYZBQSA-N
SMILES: O=C1C2=C(O)C=C(C(O)=O)C=C2[C@@]([C@]3([H])C4=CC(C(O)=O)=CC(O)=C4C(C5=C(O)C=CC=C35)=O)([H])C6=CC=CC(O)=C16
Biological Activity: Sennidin B is an anthraquinone compound isolated from Cassia angustifolia. Sennidin B is a DPP-4 inhibitor with an IC50 of 39.39 μM. Sennidin B is an insect chitinase inhibitor with a Ki of 80 nM against OfChi-h. Sennidin B competitively inhibits chitinase activity by forming π-π stacking interactions with key tryptophan residues in the active site through a folded conformation. Sennidin B activates PI3K/Akt to promote glucose uptake in adipocytes. Sennidin B can be used for the development of biopesticides and research on type 2 diabetes and metabolism-related signaling pathways[1][2][3][4].
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Sennidin B | 99.25% | Sennidin B is an anthraquinone compound isolated from Cassia angustifolia. Sennidin B is a DPP-4 inhibitor with an IC50 of 39.39 μM. Sennidin B is an insect chitinase inhibitor with a Ki of 80 nM against OfChi-h. Sennidin B competitively inhibits chitinase activity by forming π-π stacking interactions with key tryptophan residues in the active site through a folded conformation. Sennidin B activates PI3K/Akt to promote glucose uptake in adipocytes. Sennidin B can be used for the development of biopesticides and research on type 2 diabetes and metabolism-related signaling pathways. | ||||||||||||||||||||
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Sennidin B (Standard) | ≥98% | Sennidin B Standard is the analytical standard of Sennidin B (HY-N6935). This product is intended for research and analytical applications. Sennidin B is an anthraquinone compound isolated from Cassia angustifolia. Sennidin B is a DPP-4 inhibitor with an IC50 of 39.39 μM. Sennidin B is an insect chitinase inhibitor with a Ki of 80 nM against OfChi-h. Sennidin B competitively inhibits chitinase activity by forming π-π stacking interactions with key tryptophan residues in the active site through a folded conformation. Sennidin B activates PI3K/Akt to promote glucose uptake in adipocytes. Sennidin B can be used for the development of biopesticides and research on type 2 diabetes and metabolism-related signaling pathways. | ||||||||||||||||||||
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References
- [1]. Abe D, et al. Sennidin stimulates glucose incorporation in rat adipocytes. Life sciences. 2006 Aug 08;79(11):1027-33.
- [2]. Ali S, et al. Ensemble Machine Learning- and Deep Learning-Driven Identification and Validation of Sennidin B as a Novel Dipeptidyl Peptidase-4 Inhibitor. International journal of molecular sciences. 2026 Jun 18;27(12):5536.
- [3]. Furuta A, et al. Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. International journal of molecular sciences. 2015 Aug 07;16(8):18439-53. [Content Brief]
- [4]. Pang Z, et al. Discovery of Sennidin B as a Potent Multitarget Inhibitor of Insect Chitinolytic Enzymes. Journal of agricultural and food chemistry. 2025 May 14;73(19):11661-11669.
