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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
852 Results for "
hepatically
" in MedChemExpress (MCE) Product Catalog:
Products (852)
852 Results for "hepatically" in MCE Product Catalog:
Cat. No.: HY-W012846
CAS No.: 2418-52-2
Category:
Other Diseases Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Saccharides
Target:
Cat. No.: HY-W768347
Synonyms: Xylite-13C5
Cat. No.: HY-W996116
CAS No.: 1933460-23-1
Target:
Domaines de recherche:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
AZM198 is an orally active myeloperoxidase (MPO) inhibitor. AZM198 irreversibly inactivates MPO (IC50=0.015 μM) via covalent binding to the heme prosthetic group, preferentially targets extracellular MPO activity, and reduces neutrophil extracellular trap formation, reactive oxygen species production and degranulation. AZM198 increases the fibrous cap thickness of atherosclerotic plaques, reduces lesion area, ameliorates hepatic steatosis and fibrosis in non-alcoholic steatohepatitis, and alleviates proteinuria and inflammatory infiltration associated with glomerulonephritis. AZM198 also decreases circulating levels of high-sensitivity Cardiac Troponin I and IL-1β, and mitigates endothelial cell injury. Therefore, AZM198 is suitable for research on various MPO-related diseases, including atherosclerotic cardiovascular disease, myocardial infarction, ischemic stroke, non-alcoholic steatohepatitis and crescentic glomerulonephritis .
Cat. No.: HY-10585AG
CAS No.: 1069-66-5
Synonyms: Sodium Valproate (GMP); VPA sodium (GMP); 2-Propylpentanoic acid sodium (GMP)
Cat. No.: HY-181117
CAS No.: 86886-76-2
YTH-IN-2 is a YTH domain inhibitor of YTHDC2 with an IC50 of 16.84 μM. YTH-IN-2 can serve as a lead compound for discovering efficient, selective, and cell-active small-molecule inhibitors of YTHDC2.
Cat. No.: HY-N0110R
CAS No.: 10605-02-4
Cat. No.: HY-W096907
CAS No.: 213-46-7
Target:
Domaines de recherche:
Picene is a polycyclic aromatic hydrocarbon of environmental relevance. Picene can be widely distributed in the environment as the result of incomplete combustion of organic matter. Picene is found to be inactive as complete carcinogen, while it acts in a high dose as a weak tumor initiator .
Cat. No.: HY-106818
CAS No.: 103377-41-9
Synonyms: AJ-2615 free base
Target:
Domaines de recherche:
Monatepil (AJ-2615 free base) is a calcium antagonist with potent α1-adrenoceptor blocking activity. Monatepil inhibits vasopressin- or methacholine-induced ischemic electrocardiographic changes in a rat model of vasospastic angina and reduces the mean arterial pressure in anesthetized rats. Monatepil also enhances low-density lipoprotein (LDL) receptor activity in human skin fibroblasts . Monatepil can be used in research related to hypertension, atherosclerosis, hyperlipidemia and vasospastic angina .
Cat. No.: HY-111096
CAS No.: 254750-11-3
Target:
Domaines de recherche:
IDN-7314 is a pan-Caspase inhibitor with an IC50 of 0.2-7 nM against all tested Caspases. IDN-7314 abrogates Jo2-induced caspase-3/7 activity. IDN-7314 reduces the procoagulant activity of tissue factor in hepatocytes. IDN-7314 is applicable to research related to chemically induced hepatitis, fulminant liver failure and apoptotic liver injury .
Cat. No.: HY-13582A
CAS No.: 37574-18-8
Carbendazim hydrochloride is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim hydrochloride is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
Cat. No.: HY-13582R
CAS No.: 10605-21-7
Target:
Carbendazim (Standard) is the analytical standard of Carbendazim. This product is intended for research and analytical applications. Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
Cat. No.: HY-135876
CAS No.: 29873-99-2
Synonyms: (-)-γ-Elemene
Cat. No.: HY-184246
CAS No.: 2791469-19-5
Target:
Domaines de recherche:
SR-34831 is a NAMPT activator, NAD level stabilizer and neuroprotective agent. SR-34831 enhances the enzymatic activity of human NAMPT, prevents intracellular NAD depletion, and counteracts neuronal death induced by toxic misfolded prion proteins. SR-34831 exhibits metabolic stability in human liver microsomes and can be used for the research of protein misfolding neurodegenerative diseases .
Cat. No.: HY-184247
CAS No.: 2791469-14-0
Target:
Domaines de recherche:
SR-32685 is a NAMPT activator and neuroprotective agent. SR-32685 enhances the enzymatic activity of hNAMPT, prevents intracellular NAD depletion, and protects neurons from death induced by toxic misfolded prion proteins. SR-32685 can be used in the research of protein misfolding neurodegenerative diseases and metabolic diseases .
Cat. No.: HY-N0046
CAS No.: 88105-29-7
Synonyms: Notoginseng triterpenes; Ginsenoside Mb
Cat. No.: HY-P991574
CAS No.: 2643310-75-0
Synonyms: REG-101
Target:
Domaines de recherche:
Cat. No.: HY-W001084
CAS No.: 14199-15-6
Target:
Cat. No.: HY-125539
CAS No.: 16891-85-3
Category:
Target:
Cat. No.: HY-14674A
CAS No.: 543681-31-8
CP-724714 succinate is an orally active and selective HER2 tyrosine kinase inhibitor with an IC50 of 10 nM. CP-724714 succinate inhibits HER2 receptor autophosphorylation and blocks the downstream Ras-Raf-Mek-Erk signaling pathway, thereby inducing cell cycle arrest and apoptosis in tumor cells. CP-724714 succinate exhibits antiviral activity and inhibits various porcine diarrheal coronaviruses, including SADS-CoV (IC50 of 0.91 μM). CP-724714 succinate is an inhibitor of the hepatic transport receptors OATP1B1/MDR1/BSEP, and can enter hepatocytes via active uptake and trigger the accumulation of drugs and bile acids within hepatocytes. CP-724714 succinate can be used in research related to HER2-overexpressing breast cancer and porcine diarrheal coronavirus infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
