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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
78 Results for "
MMP 3
" in MedChemExpress (MCE) Product Catalog:
Products (78)
78 Results for "MMP 3" in MCE Product Catalog:
Cat. No.: HY-153913
CAS No.: 333746-76-2
Target:
Research Areas:
MMP-9-IN-7 is a potent MMP9 inhibitor with an IC50 of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research .
Cat. No.: HY-P4937
CAS No.: 945414-97-1
Cat. No.: HY-18694A
CAS No.: 161314-70-1
Target:
Research Areas:
CGS 27023A free base is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A free base prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A free base can be used for study of arthritis .
Cat. No.: HY-12168B
CAS No.: 179545-76-7
Synonyms: (Rac)-BAY 12-9566
(Rac)-Tanomastat ((Rac)-BAY 12-9566) is the racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models .
Cat. No.: HY-114091A
CAS No.: 766536-21-4
Target:
Research Areas:
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively .
Cat. No.: HY-103444R
CAS No.: 704888-90-4
Target:
Research Areas:
ARP-100 (Standard) is the analytical standard of ARP-100. This product is intended for research and analytical applications. ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) .
Cat. No.: HY-113952R
CAS No.: 13434-13-4
Synonyms: (-)-Actinonin (Standard)
Category:
Cat. No.: HY-P73297
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMP3; SL-1; Prev. STMY1; Matrix Metalloproteinase 3; Prev. STMY; Proteoglycanase; Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase); Stromelysin 1; Stromelysin-1; CHDS6; Transin-1; STR1; MMP-3; Matrix Metallopeptidase 3; Matrix Metalloproteinase-3
Species:
Human
Source:
E. coli
Cat. No.: HY-P70139
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MMP3; SL-1; Prev. STMY1; Matrix Metalloproteinase 3; Prev. STMY; Proteoglycanase; Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase); Stromelysin 1; Stromelysin-1; CHDS6; Transin-1; STR1; MMP-3; Matrix Metallopeptidase 3; Matrix Metalloproteinase-3
Species:
Human
Source:
HEK293
Cat. No.: HY-187685
CAS No.: 147485-09-4
Target:
Research Areas:
L 696418 is a MMP-3 inhibitor with a Ki value of 310 nM. L 696418 inhibits MMP-3 activity, thereby preventing the release of proteoglycans from cartilage. L 696418 reduces proteoglycan release in rabbit knee joints exposed to interleukin-1β (IL-1β). L 696418 can be used in research related to cartilage degradation .
Cat. No.: HY-125507
CAS No.: 306733-22-2
Target:
Research Areas:
F81-1144b is a MMP-1 and MMP-3 inhibitor with IC50 values of 5 nM and 29 nM, respectively. F81-1144b reduces serum and hepatic triacylglycerol levels, decreases the secretion of very-low-density lipoprotein-triacylglycerol, inhibits de novo hepatic fatty acid synthesis, and lowers serum insulin and glucose levels. F81-1144b can be used for the research of hypertriglyceridemia .
Cat. No.: HY-12270S
Cat. No.: HY-107428R
CAS No.: 199850-67-4
Target:
Research Areas:
PD-166793 (Standard) is the analytical standard of PD-166793 (HY-107428). This product is intended for research and analytical applications. PD-166793 is a potent, selective, orally active and wide-broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC50=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure .
Cat. No.: HY-110397R
CAS No.: 1365803-52-6
Target:
Research Areas:
KP-457 (Standard) is the analytical standard of KP-457 (HY-110397). This product is intended for research and analytical applications. KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
Cat. No.: HY-183764
Research Areas:
COX-2/5-LOX-IN-8 is an orally active dual COX-2/5-LOX inhibitor, with an IC50 of 6.30 μM against sheep-derived COX-2 and an IC50 of 8.09 μM against 5-LOX. COX-2/5-LOX-IN-8 acts as a membrane stabilizer that stabilizes erythrocyte membranes against hypotonicity-induced hemolysis. COX-2/5-LOX-IN-8 functions as a protein stabilizer that inhibits heat-induced denaturation of bovine serum albumin. COX-2/5-LOX-IN-8 reduces paw swelling, improves hind limb weight-bearing function, decreases serum levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, CRP), and lowers serum levels of cartilage degradation biomarkers (COMP, MMP-3, CTX-II). COX-2/5-LOX-IN-8 can be used in the research of osteoarthritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
