306733-22-2
Chemical Structure
F81-1144b
- CAS No.: 306733-22-2
- Formula:C27H37N3O5
- Molecular Weight:483.60
IUPAC Name: (S)-3-(4-(aminomethyl)phenyl)-2-((2R,3S)-3-(hydroxycarbamoyl)-2-isobutyl-6-phenylhexanamido)propanoic acid
InChIKey: GFAZZKCPOBPJMA-VXNXHJTFSA-N
SMILES: O=C([C@H](CC1=CC=C(C=C1)CN)NC([C@@H]([C@H](CCCC2=CC=CC=C2)C(NO)=O)CC(C)C)=O)O
Biological Activity: F81-1144b is a MMP-1 and MMP-3 inhibitor with IC50 values of 5 nM and 29 nM, respectively. F81-1144b reduces serum and hepatic triacylglycerol levels, decreases the secretion of very-low-density lipoprotein-triacylglycerol, inhibits de novo hepatic fatty acid synthesis, and lowers serum insulin and glucose levels. F81-1144b can be used for the research of hypertriglyceridemia[1].
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F81-1144b | F81-1144b is a MMP-1 and MMP-3 inhibitor with IC50 values of 5 nM and 29 nM, respectively. F81-1144b reduces serum and hepatic triacylglycerol levels, decreases the secretion of very-low-density lipoprotein-triacylglycerol, inhibits de novo hepatic fatty acid synthesis, and lowers serum insulin and glucose levels. F81-1144b can be used for the research of hypertriglyceridemia. | |||||||||||||||||||||
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