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Cat. No.: HY-187685

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L 696418

L 696418 is a MMP-3 inhibitor with a K_i value of 310 nM. L 696418 inhibits MMP-3 activity, thereby preventing the release of proteoglycans from cartilage. L 696418 reduces proteoglycan release in rabbit knee joints exposed to interleukin-1β (IL-1β). L 696418 can be used in research related to cartilage degradation.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 147485-09-4
Formule: C₂₅H₃₃N₃O₄
Masse moléculaire:439.55

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Please store the product under the recommended conditions in the Certificate of Analysis.

L 696418 Chemical Structure

CAS No.: 147485-09-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Classifications
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Activité biologique

Description

IC₅₀ & Target^[1]

MMP-3

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In Vivo

Intravenous administration of L 696418 inhibits proteoglycan release by approximately 50% in rabbit knee joints treated with intra-articular injection of human MMP-3 and IL-1β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 147485-09-4
Masse moléculaire 439.55
Formule C₂₅H₃₃N₃O₄
SMILES

C[C@H](C(O)=O)N[C@H](C(N[C@@H](CC(C)C)C(NC1=CC=CC=C1)=O)=O)CCC2=CC=CC=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Esser CK, et al. Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. Journal of medicinal chemistry. 1997 Mar 14;40(6):1026-40.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références

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L 696418

Voir tous les produits spécifiques à Isoform MMP