71 Results for "

background

" in MedChemExpress (MCE) Product Catalog:
Products (71)

71 Results for "background" in MCE Product Catalog:

Cat. No.: HY-180306
CAS No.: 84693-92-5
Fluoroestradiol is an Estrogen receptor PET imaging tracer precursor. Fluoroestradiol, when radiolabeled with 18F, can be used as an Estrogen receptor PET imaging tracer. 18F-Fluoroestradiol exhibits the highest uptake selectivity and target-to-background ratio among
several 18F-labeled estrogens. 18F-Fluoroestradiol has demonstrated Estrogen receptor expression in normal brain tissues and in meningiomas. 18F-Fluoroestradiol can quantify regional Estrogen receptor expression in breast cancer. 18F-Fluoroestradiol has potential applications in assessing and monitoring heterogeneity in ovarian cancer .
loading...
    loading...
Cat. No.: HY-D3195
CAS No.: 2028316-19-8
CDr15 is a deep-red fluorescent probe (Ex=733 nm) that can selectively intercalate into and label bacterial extracellular DNA (eDNA). CDr15 exhibits extremely high specificity for biofilm imaging and cannot effectively bind to mammalian nuclear DNA. CDr15 enables real-time visualization of the microcolony structure and developmental process of three-dimensional *Pseudomonas aeruginosa* biofilms, and accurately localizes biofilm-forming regions of microorganisms in a mouse corneal infection model. With low background interference signals, CDr15 serves as an ideal diagnostic tool for research fields including bacterial biofilms and corneal infections .
loading...
    loading...
Cat. No.: HY-W800699
CAS No.: 2644752-85-0
BP Fluor 430 DBCO reacts with azides via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 430 DBCO is an ideal alternative to copper requiring fluorescent alkynes. BP Fluor 430 is a bright, photostable, green-fluorescent probe optimally excited near its absorption maximum at 432 nm. Its emission peak at 539 nm is pH independent over a wide pH range. BP Fluor DBCO reagent is not suitable for staining intracellular components of fixed and permeabilized cells due to high backgrounds.
loading...
    loading...
Cat. No.: HY-D2924
CBG-549-QSY7 is a Dylight 549-labeled SNAP tag fluorescent probe (Ex/Em: 546 nm/580 nm), specially designed for non-washable fluorescence imaging applications. CBG-549-QSY7 employs an intramolecular FRET quenching mechanism: intramolecular fluorescence quenching occurs before binding to the SNAP tag, and upon binding, the quenching group is cleaved, releasing fluorescence. The background fluorescence of CBG-549-QSY7 is extremely low, and clear cell membrane images can be obtained after 5 minutes of incubation .
loading...
    loading...
Cat. No.: HY-D3361
Target:  

Fluorescent Dye

Research Areas:  

Others

JF639-HTL is a deep-red fluorescent dye belonging to the Janelia Fluor series and also a HaloTag ligand. JF639-HTL contains a methoxy group as the R substituent, which forms a specific covalent bond with HaloTag fusion proteins. JF639-HTL is fluorogenic, exhibiting low background fluorescence in solution and a significant fluorescence enhancement upon binding to proteins. It also possesses cell permeability and excellent photostability. JF639-HTL can be used in studies related to fluorescent labeling, localization tracking, and pulse-chase imaging of proteins in living cells .
loading...
    loading...
Cat. No.: HY-DY2022
Target:  

Fluorescent Dye

Research Areas:  

Others

Eosin-Nigrosin Sperm Viability Staining Solution is a differential viability staining solution used to distinguish live/dead sperm and other cells, consisting of Eosin Y (HY-D0505) and Nigrosin (HY-W250145). Eosin-Nigrosin Sperm Viability Staining Solution cannot penetrate the membrane of live cells; it stains dead cells dark pink and uses nigrosin to form a contrasting dark background. Eosin-Nigrosin Sperm Viability Staining Solution can distinguish live sperm, dead sperm and sperm with neck leakage, and can stain dead sperm or sperm affected by excessive microbial growth .
loading...
    loading...
Cat. No.: HY-D3197
CDg16 is a selective fluorescent dye targeting SLC18B1 (λabsem=458/544 nm) that is actively transported into lysosomal vesicles of activated macrophages independent of the endocytic pathway. CDg16 enables highly specific vesicle localization in live cells. CDg16 exhibits no cytotoxicity and accurately distinguishes activated M1 and M2 subsets from different origins. CDg16 shows low background staining in non-activated cells and normal organs, making it suitable for time-lapse imaging. In preclinical animal models of inflammatory sites, atherosclerotic plaques and liver inflammation, CDg16 allows visualization of activated macrophages. CDg16 can be used to study inflammation-related diseases and atherosclerosis .
loading...
    loading...
Cat. No.: HY-D3391
RMR-Tre is a fluorescent probe targeting the mycobacterial acyltransferase Ag85. Under the catalysis of Ag85, RMR-Tre undergoes 6-position mycoloylation and anchors to the mycobacterial membrane, while achieving fluorescence activation by inhibiting the intramolecular twisted charge transfer state transition. RMR-Tre can distinguish live mycobacteria from dead ones through metabolism-driven labeling, enabling rapid, wash-free, low-background detection of viable bacteria. RMR-Tre reports the drug resistance of Mycobacterium tuberculosis via the trehalose catalytic shift activity readout associated with TreS. In addition, RMR-Tre can be combined with flow cytometry or high-content imaging techniques to visualize and quantitatively analyze the metabolic heterogeneity of Mycobacterium tuberculosis related to persistence and drug resistance. RMR-Tre is widely used in tuberculosis-related research .
loading...
    loading...
Cat. No.: HY-DY2041
Target:  

Fluorescent Dye

Research Areas:  

Infection

Callose Staining Solution (Aniline Blue, Bright-Field Method) is a fluorescent dye used for detecting callose in plant tissues, green algal cell walls, plant cells, and protoplasts. Callose Staining Solution (Aniline Blue, Bright-Field Method) specifically binds to callose, a β-(1,3)-D-glucan polymer, and exhibits blue-green fluorescence under alkaline conditions with reduced background staining and non-toxicity to living cells. Callose Staining Solution (Aniline Blue, Bright-Field Method) is suitable for observation under UV or epifluorescence microscopy (Ex/Em = 365-370/397-509 nm). Callose Staining Solution (Aniline Blue, Bright-Field Method) can be used in studies related to the visualization of callose deposition in plants .
loading...
    loading...
Cat. No.: HY-P11590
Target:  

EGFR

Research Areas:  

Cancer

WGYRGFYC (WC8) is a selective HER2-targeting peptide that binds specifically to HER2 by mimicking the antigen-binding site of trastuzumab. The DOTA precursor of WGYRGFYC has a KD of 61.20 nM for HER2. WGYRGFYC enables specific and highly sensitive detection of HER2 expression in HER2-positive breast cancer cells and tumor tissues, and monitors the dynamic downregulation of HER2 expression. WGYRGFYC rapidly distributes to target tissues and is efficiently cleared from non-target tissues via the kidneys, generating an ideal tumor-to-background ratio in imaging; it is a component of the PET radiotracer Ga-DOTA-WC8. WGYRGFYC exhibits no significant cytotoxicity in breast cancer cells, and can be used for non-invasive imaging diagnosis and therapeutic efficacy evaluation of HER2-positive breast cancer .
loading...
    loading...
Cat. No.: HY-D3525
Target:  

Fluorescent Dye

Research Areas:  

Others

BDL-E5 is a fluorescent probe for detecting live induced pluripotent stem cells at the early reprogramming stage. Its detection mechanism involves specific binding to authentic reprogramming cells, which exhibit increased expression of pluripotency and epithelial genes and decreased expression of mesenchymal genes compared to non-reprogramming cells; it appears to co-localize more significantly with the Golgi complex than other organelle markers in reprogramming cells, and it does not require washing after staining to reduce background signals; fluorescence is generated upon binding to these early reprogramming cells, with positive cells appearing 7 days before iPS colonies are visible and stain positive for the conventional pluripotent marker TRA-1-60, and sorting BDL-E5-positive cells enriches populations that generate higher numbers and quality of iPS colonies. Its detection wavelength is Ex/Em = 578/599 nm .
loading...
    loading...