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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
118 Results for "
3CLpro
" in MedChemExpress (MCE) Product Catalog:
Products (118)
118 Results for "3CLpro" in MCE Product Catalog:
Cat. No.: HY-17430S
CAS No.: 1217661-20-5
Cat. No.: HY-17430R
CAS No.: 161814-49-9
Synonyms: VX-478 (Standard)
Target:
Amprenavir (Standard) is the analytical standard of Amprenavir. This product is intended for research and analytical applications. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.
Cat. No.: HY-160594
CAS No.: 890648-80-3
Target:
Research Areas:
SARS 3CLpro-IN-2 (Example 9) is a severe acute respiratory syndrome 3C-like protease (SARS 3CL pro) inhibitor with an IC50 of 0.02 mM. It exhibits antiviral activity against SARS with an EC50 of 42 mM. SARS 3CLpro-IN-2 can be used in research related to severe acute respiratory syndrome .
Cat. No.: HY-10237S
CAS No.: 1256751-11-7
Synonyms: EBP 520-d9; SCH 503034-d9
Cat. No.: HY-90001S3
CAS No.: 1217720-20-1
Synonyms: rel-ABT 538-d6; rel-RTV-d6
Cat. No.: HY-10300R
CAS No.: 865466-24-6
Synonyms: SCH 900518 (Standard)
Target:
Research Areas:
Narlaprevir (Standard) is the analytical standard of Narlaprevir. This product is intended for research and analytical applications. Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM . Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease . Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM [3].
Cat. No.: HY-136606
CAS No.: 2413716-71-7
SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research .
Cat. No.: HY-17367S3
CAS No.: 1132747-14-8
Cat. No.: HY-17367AR
CAS No.: 229975-97-7
Synonyms: BMS-232632 sulfate (Standard)
Category:
Cat. No.: HY-10235R
CAS No.: 402957-28-2
Synonyms: VX-950 (Standard)
Target:
Research Areas:
Telaprevir (Standard) is the analytical standard of Telaprevir. This product is intended for research and analytical applications. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide [3]. Telaprevir inhibits SARS-CoV-2 3CLpro activity .
Cat. No.: HY-169974
CAS No.: 3087307-24-9
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Research Areas:
SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056)-stimulated RAW264.7 macrophages .
Cat. No.: HY-12594R
CAS No.: 1216941-48-8
Synonyms: ABT-450 (Standard); Veruprevir (Standard)
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Research Areas:
Paritaprevir (Standard) is the analytical standard of Paritaprevir. This product is intended for research and analytical applications. Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor) [3] .
Cat. No.: HY-184050
CAS No.: 1065478-52-5
MERS-CoV-IN-3 is a 3CLpro inhibitor with an IC50 of 1.7 μM against MERS-CoV 3CLpro and an IC50 of 0.2 μM against SARS-CoV 3CLpro. MERS-CoV-IN-3 functionally inhibits protease activity essential for viral replication, downregulates viral protein production, reduces the secretion of infectious viral particles, and suppresses the replication of α-coronaviruses and β-coronaviruses derived from humans and cats. MERS-CoV-IN-3 can be used in studies related to coronavirus infections .
Cat. No.: HY-183746
CAS No.: 128232-62-2
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Research Areas:
Catechin-5-O-gallate is a bioactive substance. Catechin-5-O-gallate can be isolated from bioactive Himalayan plants. Catechin-5-O-gallate is predicted to be a P-glycoprotein inhibitor, and binds to SARS-CoV-2 3CLpro, PLpro and RdRp. Catechin-5-O-gallate can be used in studies related to COVID-19 .
Cat. No.: HY-100721R
CAS No.: 1416992-39-6
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Research Areas:
GC376 (sodium) (Standard) is the analytical standard of GC376 (sodium) (HY-100721). This product is intended for research and analytical applications. GC376 sodium is a 3CLpro inhibitor; inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM, respectively.
Cat. No.: HY-152589
CAS No.: 2761367-25-1
Antiviral agent 25 (compound 6g) is a new non-peptide analog covalent inhibitor of SARS-CoV-2 3CL pro. Antiviral agent 25 has a strong inhibitory effect on SARS-CoV-2 3CL pro and SARS-CoV-2 PL pro with IC50 values of 0.118 µM, 0.448 µM, respectively. Antiviral agent 25 has antiviral effect on SARS-CoV-2 with an EC50 value of 7.249 µM .
Cat. No.: HY-180318
CAS No.: 2698348-97-7
MI-30 is an orally active SARS-CoV-2 3CLpro inhibitor (IC50 = 17.2 nM). MI-30 reduces viral load and lung lesions in a mouse model of SARS-CoV-2 infection. MI-30 may be used in coronavirus infection research .
Cat. No.: HY-111074
CAS No.: 934017-32-0
Synonyms: MK-0767 analog
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Research Areas:
DB12055 (MK-0767 analog) is a covalent SARS-CoV-2 3CL protease inhibitor. DB12055 has the potential for the study of dyslipidemia and diabetes mellitus .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
