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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
112 Results for "
SOS1
" in MedChemExpress (MCE) Product Catalog:
Products (112)
112 Results for "SOS1" in MCE Product Catalog:
Cat. No.: HY-184586
SOS1-IN-28 is an orally active, blood-brain barrier permeable SOS1 inhibitor with an IC50 value of 0.11 μM. SOS1-IN-28 disrupts the SOS1: KRAS protein-protein interaction, with an IC50 of 0.29 μM for the KRAS-RAF interaction. SOS1-IN-28 blocks GTP loading of KRAS, inhibits RAS-MAPK pathway activity, and reduces cancer cell proliferation. SOS1-IN-28 can be used for the research of KRAS G12C-mutant lung cancer [1].
Cat. No.: HY-161637
CAS No.: 2633633-39-1
Target:
Research Areas:
E3 ligase Ligand 25 (part of Compd 1) is a ligand for E3 ligase, used for the synthesis of PROTAC SOS1 degrader (HY-161634) [1].
Cat. No.: HY-161639
CAS No.: 2911613-35-7
Target:
Research Areas:
E3 ligase Ligand 26 (part of Compd 10) is a ligand for E3 ligase, used for the synthesis of PROTAC SOS1 degrader (HY-161636) [1].
Cat. No.: HY-161638
CAS No.: 2911613-56-2
Research Areas:
E3 Ligase Ligand-linker Conjugate 108 is a E3 ligase ligand-linker conjugate, used for the the synthesis of PROTAC SOS1 degrader (HY-161634) [1].
Cat. No.: HY-161640
CAS No.: 2911613-55-1
Research Areas:
E3 Ligase Ligand-linker Conjugate 109 is a E3 ligase ligand-linker conjugate, used for the the synthesis of PROTAC SOS1 degrader (HY-161636) [1].
Cat. No.: HY-161657
Research Areas:
2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP is an E3 Ligase ligand-linker conjugate, and can be used for synthesis of PROTAC SOS1 degrader-10 (HY-161654) [1].
Cat. No.: HY-161656
CAS No.: 3027978-51-1
Target:
Research Areas:
PIP-C-3-Azaspiro[5.5]undecane-boc is the linker for PROTAC. PIP-C-3-Azaspiro[5.5]undecane-boc is utilized for synthesis of PROTAC SOS1 degrader-10 (HY-161654) [1].
Cat. No.: HY-151968
CAS No.: 2821863-70-9
KRAS G12C inhibitor 57 (Compound 50) is a potent, selective, covalent and orally active KRAS G12C inhibitor with an IC50 of 0.21 μM in KRAS G12C/SOS1 binding assay. KRAS G12C inhibitor 57 induces cancer cell apoptosis [1].
Cat. No.: HY-175891
CAS No.: 2836274-72-5
Research Areas:
POI ligand-5 (Compound M8) is a SOS1 ligand that can be used to synthesize PROTACs, such as PROTAC SOS1 degrader-5 (HY-161173) [1].
Cat. No.: HY-183365
SL43 is an orally active and potent SOS1 inhibitor with a Kd of 0.16 μM. SL43 disrupts SOS1-KRAS interaction, inhibits SOS1-mediated nucleotide exchange on KRAS mutants, and suppresses RAS-MAPK signaling. SL43 exerts antiproliferative activity against KRAS-mutant cancer cells, induces early apoptosis and G1 phase cell cycle arrest, and reduces phosphorylated MEK and ERK levels. SL43 suppresses tumor growth in a colorectal cancer xenograft model [1].
Cat. No.: HY-P704193
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SOS1; Son Of Sevenless Homolog 1 (Drosophila), Isoform CRA_d; Prev. GINGF; Guanine Nucleotide Exchange Factor; HGF; Uncharacterized Protein SOS1; GF1; Alternate SOS1; Gingival Fibromatosis, Hereditary, 1; GGF1; Son Of Sevenless Homolog 1; NS4; SOS-1; SOS
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-184855
Target:
Research Areas:
(S,S,S,S)-AHPC-Me is an E3 ligase ligand that can be used in research related to PROTAC synthesis, such as serving as the E3 ligase ligand for (4S)-PROTAC SOS1 degrader-1 (HY-144657) [1].
Cat. No.: HY-182411
CAS No.: 2375482-34-9
KRAS-IN-56 (Compound 18) is a KRAS inhibitor with an EC50 of 33 μM. KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1. KRAS-IN-56 induces a decrease in p-ERK levels. KRAS-IN-56 can be used in research related to lung cancer [1].
Cat. No.: HY-187998
CAS No.: 3034975-33-9
AM-8719 is an orally active, blood-brain barrier-penetrant KRAS G12C inhibitor. AM-8719 binds covalently to KRAS G12C, inhibits SOS1-catalyzed GDP/GTP exchange, and suppresses downstream ERK phosphorylation. AM-8719 exhibits antiproliferative activity against KRAS G12C tumor cells. AM-8719 can be used for the research of KRAS G12C-positive cancers [1].
Cat. No.: HY-163584
Target:
Research Areas:
HOOC-Piperidine-CH2-3-azaspiro[5.5]undecane-Boc is a PROTAC linker that can be used for the synthesis of PROTACs, such as PROTAC SOS1 degrader-7 (HY-163582) [1].
Cat. No.: HY-187519
KRAS-IN-61 is an orally effective pan-KRAS inhibitor that potently inhibits SOS1-mediated KRAS nucleotide exchange (IC50 <10 nM for KRAS G12D/G12V/G12C/WT). KRAS-IN-61 inhibits pERK signaling and cell proliferation in KRAS-mutant tumor cells. KRAS-IN-61 can inhibit tumor growth in vivo. KRAS-IN-61 can be used in studies of KRAS mutation-related cancers, such as colorectal cancer [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
