3034975-33-9
3034975-33-9
Chemical Structure
AM-8719
- CAS No.: 3034975-33-9
- Formula:C31H40F3N7O3
- Molecular Weight:615.69
InChIKey: FMSUCDUEHJQYNM-FYYLOGMGSA-N
SMILES: COC1(COC1)C2=NC=CC(C)=C2C(CC3)CCN3C4=CC(N5C[C@H]([C@H]5C)N(CC6)CCN6C(C=C)=O)=NC(C(F)(F)F)=N4
Biological Activity: AM-8719 is an orally active, blood-brain barrier-penetrant KRASG12C inhibitor. AM-8719 binds covalently to KRASG12C, inhibits SOS1-catalyzed GDP/GTP exchange, and suppresses downstream ERK phosphorylation. AM-8719 exhibits antiproliferative activity against KRASG12C tumor cells. AM-8719 can be used for the research of KRASG12C-positive cancers[1].
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AM-8719 | AM-8719 is an orally active, blood-brain barrier-penetrant KRASG12C inhibitor. AM-8719 binds covalently to KRASG12C, inhibits SOS1-catalyzed GDP/GTP exchange, and suppresses downstream ERK phosphorylation. AM-8719 exhibits antiproliferative activity against KRASG12C tumor cells. AM-8719 can be used for the research of KRASG12C-positive cancers. | |||||||||||||||||||||
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