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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
127 Results for "
5-HT6
" in MedChemExpress (MCE) Product Catalog:
Products (127)
127 Results for "5-HT6" in MCE Product Catalog:
Cat. No.: HY-107125
CAS No.: 1194574-68-9
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AVN-322 is an orally active, highly selective 5-HT6Rantagonist for central nervous system disease research .
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AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM).
Cat. No.: HY-107125A
CAS No.: 1194574-33-8
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AVN-322 free base is an orally active, highly selective 5-HT6Rantagonist for central nervous system disease research .
Cat. No.: HY-172679
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PUC-55 is a 5-HT6R antagonist with a Ki of 37.5 nM that induces neuronal autophagy by inhibiting the mTOR pathway. It holds potential for research in the field of neurological disorders .
Cat. No.: HY-RS06464
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HTR1F Human Pre-designed siRNA Set A contains three designed siRNAs for HTR1F gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-19668
CAS No.: 445441-26-9
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SGS-518 is a selective 5-HT6R antagonist. SGS518 can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses .
Cat. No.: HY-19668A
CAS No.: 445441-27-0
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SGS518 oxalate is a selective 5-HT6R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses [1]
Cat. No.: HY-109036A
CAS No.: 1000308-09-7
Synonyms: (S)-RO5025181; (S)-SYN120
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(S)-Landipirdine ((S)-RO5025181), a selective and potent 5-HT6R antagonist, significantly impacts the hERG pharmacophore and serves as a valuable tool for investigating neurological disorders, particularly within the context of Alzheimer's disease.
Cat. No.: HY-155330
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PZ-1922 (Compound 16) is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 reversibly inhibits MAO-B (pIC50: 8.93). PZ-1922 reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 prevents Aβ-induced memory decline in the T-maze test .
Cat. No.: HY-155330A
CAS No.: 1648745-65-6
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PZ-1922 free base is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 free base reversibly inhibits MAO-B (pIC50: 8.93). PZ-1922 free base reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 free base prevents Aβ-induced memory decline in the T-maze test .
Cat. No.: HY-101924R
CAS No.: 1220646-23-0
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AVN-492 (Standard) is the analytical standard of AVN-492 (HY-101924). This product is intended for research and analytical applications. AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM).
Cat. No.: HY-143329
CAS No.: 3037516-21-2
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MAO-B-IN-3 is a reversible and selective MAO-B inhibitor (IC50=96 nM). MAO-B-IN-3 also binds to 5-HT6R with Ki value of 696 nM. MAO-B-IN-3 can be used for research of in Alzheimer's disease .
Cat. No.: HY-103130A
CAS No.: 54635-62-0
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EMD386088 free base is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 free base induces cell death. EMD386088 free base regulates the activity of ERK1/2. EMD386088 free base has the potential for the research of alzheimer's disease (AD) and schizophrenia .
Cat. No.: HY-170908
CAS No.: 19622-05-0
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Pellotine is an alkaloid that can be isolated from Lophophora. Pellotine is the inverse agonist for 5-HT7 receptor with an EC50 of 291 nM. Pellotine exhibits good affinity to 5-HT1DR and 5-HT6R with Ki of 117 nM and 170 nM. Pellotine reduces intracellular cAMP levels, thereby reducing neuronal excitability and neurotransmitter release .
Cat. No.: HY-105998
CAS No.: 1173103-84-8
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AVN-211 (CD-008-0173) is a selective and orally active 5HT6R antagonist with an IC50 of 2.34 nM and a Ki of 1.09 nM. AVN-211 exhibits 5K-fold higher 5HT6R selectivity over other 65 receptors, enzymes, and ion channels. AVN-211 significantly improves cognitive and anxiety behaviors in various AD animal models, and has good safety profiles. AVN-211 can be used for the study of Alzheimer's dementia .
Cat. No.: HY-169156
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HDAC6-IN-49 (Compound 3) is an inhibitor for HDAC with IC50 of 0.012 and 0.735 μM for HDAC6 and HDAC1. HDAC6-IN-49 also exhibits inhibitory activities against MAO-B, cholinesterase (ChE), histamine receptor (H3R) and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective efficacy on SH-SY5Y cell. HDAC6-IN-49 improves cognitive function and locomotor ability in Drosophila Parkinson's disease models and in C. elegans Alzheimer's disease models .
Cat. No.: HY-W015169
CAS No.: 608-07-1
Synonyms: O-Methylserotonin
Cat. No.: HY-W015169A
CAS No.: 66-83-1
Category:
Alkaloids Neurological Disease Endogenous metabolite Disease Research Fields Cancer Indole Alkaloids
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Cat. No.: HY-W015169AR
CAS No.: 66-83-1
Category:
Cat. No.: HY-W015169R
CAS No.: 608-07-1
Synonyms: O-Methylserotonin (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
