1648745-65-6
1648745-65-6
Chemical Structure
PZ-1922 free base
- CAS No.: 1648745-65-6
- Formula:C22H21ClN4
- Molecular Weight:376.88
InChIKey: MFUVKDHSDIAPMH-UHFFFAOYSA-N
SMILES: ClC1=CC=CC(CN2C=CC3=C2C4=C(C=CC=C4)N=C3N5CCNCC5)=C1
Biological Activity: PZ-1922 free base is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 free base reversibly inhibits MAO-B (pIC50: 8.93). PZ-1922 free base reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 free base prevents Aβ-induced memory decline in the T-maze test[1].
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PZ-1922 free base | PZ-1922 free base is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 free base reversibly inhibits MAO-B (pIC50: 8.93). PZ-1922 free base reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 free base prevents Aβ-induced memory decline in the T-maze test. | |||||||||||||||||||||
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References
Keywords
