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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
154 Results for "
gap
" in MedChemExpress (MCE) Product Catalog:
Products (154)
154 Results for "gap" in MCE Product Catalog:
Cat. No.: HY-E71605A
Target:
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2-Oxoaldehyde dehydrogenase (NADP+) (EC 1.2.1.49) is an NADP+-dependent glyceraldehyde-3-phosphate dehydrogenase that catalyzes the oxidation and phosphorylation of glyceraldehyde-3-phosphate (GAP) to produce 1,3-bisphosphoglycerate (1,3-BPG), while simultaneously reducing NADP+ to NADPH.
Cat. No.: HY-P811818
Synonyms: ARFgap3; ARF GTPase Activating Protein 3; ADP Ribosylation Factor GTPase Activating Protein 3; ARFgap1; ADP-Ribosylation Factor GTPase Activating Protein 1; ADP-Ribosylation Factor GTPase-Activating Protein 3; ARF gap 3
Cat. No.: HY-P811818A
Synonyms: ARFgap3; ARF GTPase Activating Protein 3; ADP Ribosylation Factor GTPase Activating Protein 3; ARFgap1; ADP-Ribosylation Factor GTPase Activating Protein 1; ADP-Ribosylation Factor GTPase-Activating Protein 3; ARF gap 3
Cat. No.: HY-134110
CAS No.: 156910-29-1
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Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
Cat. No.: HY-134055
CAS No.: 45280-17-9
Synonyms: Arachidonic acid-N,N-dimethyl amide
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Research Areas:
Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N,N-dimethyl amide is an analog of anandamide that exhibits weak or no binding to the human central cannabinoid (CB1) receptor (Ki >1 μM). It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
Research Areas:
Prednisolone hemisuccinate (Standard) (Prednisolone 21-hemisuccinate (Standard)) is the analytical standard of Prednisolone hemisuccinate (HY-B1087). This product is intended for research and analytical applications. Prednisolone hemisuccinate (Prednisolone 21-hemisuccinate) is a prodrug of Prednisolone (HY-17463) and a glucocorticoid. Prednisolone hemisuccinate converts to Prednisolone in vivo. Prednisolone hemisuccinate induces the inactivation of glyceraldehyde-3-phosphate dehydrogenase (GAP-DH) in vitro. Prednisolone hemisuccinate can be used in research related to cataracts .
Cat. No.: HY-W769991
CAS No.: 1173021-18-5
Synonyms: Lactic acid sodium-13C2
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
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Carbenoxolone disodium (Standard) is the analytical standard of Carbenoxolone disodium (HY-B1367). This product is intended for research and analytical applications. Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD . Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication . Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.
Cat. No.: HY-181126
CAS No.: 1029737-28-7
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
G194-0712 is a selective histone deacetylase 5 (HDAC5) activator with an EC50 of 7.96 μM and a Kd of 2.53 μM. G194-0712 restores ACTN4-K417 deacetylation and nuclear import, and increases CSTA expression. G194-0712 accelerates wound closure in chronic wound models, reducing wound area and epithelial gap. G194-0712 can be used for the research of chronic skin wounds, such as diabetic wounds, ischemic wounds, radiation injury wounds .
Cat. No.: HY-A0170R
CAS No.: 147059-72-1
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Trovafloxacin (Standard) is the analytical standard of Trovafloxacin. This product is intended for research and analytical applications. Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .
Cat. No.: HY-P812025
Synonyms: ZNF289, Nbla10535, ARFgap2, ADP-ribosylation factor GTPase-activating protein 2, ARF gap 2, GTPase-activating protein ZNF289, Zinc finger protein 289
Cat. No.: HY-P811884
Synonyms: RALgapA1; Ral GTPase Activating Protein Catalytic Subunit Alpha 1; GRIPE; Tuberin-Like Protein 1; Ralgapalpha1; KIAA0884; Tulip1; GARNL1; Ral GTPase-Activating Protein Subunit Alpha-1; GTPase Activating Rap/Rangap Domain-Like 1; gap-Related Interacting Protein To E12; DKFZp667F074; P240; Ral GTPase Activating Protein, Alpha Subunit 1 (Catalytic); Ral GTPase Activating Protein Catalytic Alpha Subunit 1; GTPase-Activating Rap/Ran-gap Domain-Like 1; GTPase Activating RANgap Domain-Like 1; gap-Related-Interacting Partner To E12; NEDHRIT; TULIP1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
