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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
(S,R,S)-AHPC-Me
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "(S,R,S)-AHPC-Me" in MCE Product Catalog:
Synonyms: VHL ligand 2; E3 ligase Ligand 1A
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(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
Cat. No.: HY-42424
CAS No.: 1948273-03-7
Synonyms: VHL ligand 2 hydrochloride; E3 ligase Ligand 1
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(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
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(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 (HY-112078). (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs .
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(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 (HY-133737) and PROTAC BRD4 Degrader-5-CO-PEG3-N3 (HY-133736) .
Cat. No.: HY-42419
CAS No.: 1997302-16-5
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(S,R,S)-AHPC-Me-NHBoc is an E3 ubiquitin ligase VHL ligand used to recruit the VHL protein. (S,R,S)-AHPC-Me-NHBoc can be linked to a target protein ligand via a linker to form a PROTAC.
Cat. No.: HY-42424A
CAS No.: 2504950-56-3
Synonyms: VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride
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(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
Synonyms: (S,R,S)-AHPC-Me-PEG2-dabrafenib
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DD-03-156 ((S,R,S)-AHPC-Me-PEG2-dabrafenib) is a VHL-based PROTAC degrader targeting CDK17 and LIMK2. DD-03-156 serves as an excellent lead-like starting point for the development of selective chemical probes targeting CDK17 degradation .
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(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604) .
Cat. No.: HY-W926049
CAS No.: 2458219-89-9
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(S,R,S)-AHPC-Me-C4-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-C4-NH2 hydrochloride can be used to synthesize PROTAC.
Cat. No.: HY-132938
CAS No.: 2380273-45-8
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(S,R,S)-AHPC-Me-decanedioic acid is an E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs.
Cat. No.: HY-W1130360
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(S,R,S)-AHPC-Me-PEG3-azide is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me-PEG3-azide can be linked to a target protein ligand via a linker to form a PROTACs.
Cat. No.: HY-W998311
CAS No.: 2365173-02-8
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(S,R,S)-AHPC-Me-CO-C6-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-CO-C6-COOH can be used to synthesize PROTAC.
Cat. No.: HY-W998314
CAS No.: 2365173-01-7
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(S,R,S)-AHPC-Me-CO-C2-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-CO-C2-COOH can be used to synthesize PROTAC.
Cat. No.: HY-W998315
CAS No.: 2349429-72-5
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(S,R,S)-AHPC-Me-CO-C3-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-CO-C3-COOH can be used to synthesize PROTAC.
Cat. No.: HY-172800
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(S,R,S)-AHPC-Me-8-Sulfamoyloctanoic acid is an E3 ubiquitin ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-8-Sulfamoyloctanoic acid can be used for the synthesis of XZ338 (HY-172798) .
Cat. No.: HY-159780
CAS No.: 2458220-06-7
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Amino-PEG4-(S,R,S)-AHPC-Me is a E3 ligase ligand-linker conjugate. Amino-PEG4-(S,R,S)-AHPC-Me can be used to synthesize PROTAC NR-V04 (HY-159779) .
Cat. No.: HY-W998310
CAS No.: 2349429-73-6
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(S,R,S)-AHPC-Me-CO-C4-COOH is a conjugate of the E3 ligase VHL ligand and a linker, which can be used to synthesize PROTAC ERα Degrader-12 (HY-174453). PROTAC ERα Degrader-12 is a potent and highly selective ERα PROTAC degrader .
Cat. No.: HY-168290
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(S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide can be used in the synthesis of PROTACs, such as MS934 (HY-153863). MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader .
Cat. No.: HY-158431
CAS No.: 2638512-58-8
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(S,R,S)-AHPC-Me-8-bromooctanoic acid is an E3 ligase ligand-linker conjugate, and can be used for synthesis of PROTAC CYP1B1 degrader-2 (HY-158429) .
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(S,R,S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
