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Results for "

A2B receptor antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (35) Adrenergic Receptor (1) ERK (1) JNK (1) MMP (1) p38 MAPK (1) Phosphodiesterase (PDE) (2) PI3K (2) Reference Standards (4)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Inflammation/Immunology (17) Metabolic Disease (5) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19533

SCH 58261 Maximum Cited Publications 17 Publications Verification	Adenosine Receptor	Cancer
SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC₅₀ of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively .

HY-14121

MRS 1754 5+ Cited Publications	Adenosine Receptor	Metabolic Disease Inflammation/Immunology
MRS 1754 is a selective antagonist radioligand for **A_2B adenosine receptor** with very low affinity for A₁ and A₃ receptors of both humans and rats .

HY-103182

PSB-1115	Adenosine Receptor	Others
PSB-1115 is a selective *A2B* Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh) .

HY-103166

PSB-603 3 Publications Verification	Adenosine Receptor	Inflammation/Immunology
PSB-603 is a potent and highly selective **A_2B adenosine receptor** antagonist exhibiting a K_i value of 0.553 nM and virtually no affinity for the human and rat A₁ and A_2A and the human A₃ receptors up to a concentration of 10 μM .

HY-100678

CGS 15943	Adenosine Receptor PI3K	Inflammation/Immunology Cancer
CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its K_i for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .

HY-139314

A2B receptor antagonist 2	Adenosine Receptor	Metabolic Disease
A2B receptor antagonist 2 (compound 18) is an adenosine receptor A_2B antagonist, with K_i values of 2.30 μM, 6.8 μM and 3.44 μM for rA₁, rA_2A and hA_2B, respectively .

HY-10081

GS-6201 1 Publications Verification CVT-6883	Adenosine Receptor	Inflammation/Immunology
GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (K_i=22 nM) . GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .

HY-14117

Enprofylline	Adenosine Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
Enprofylline acts as a selective and competitive **A2B receptor** antagonist with the K_i of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease .

HY-148088

M1069 1 Publications Verification	Adenosine Receptor	Cancer
M1069 is a selective and orall active, dual A_2A/A_2B adenosine receptor antagonist with a selectivity of >100 fold against the A₁ and A₃ receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity .

HY-111767

BAY-545	Adenosine Receptor	Inflammation/Immunology
BAY-545 is a potent and selective **A_2B adenosine receptor** antagonist, with an IC₅₀ of 59 nM. BAY-545 also exhibits IC₅₀s of 66, 400, 280 nM for human, mouse, rat A_2B adenosine receptor in cells, respectively, and a K_i of 97 nM for human A_2B adenosine receptor, with more selectivity over A₁, A_2A, and A₃ adenosine receptor .

HY-111082

ISAM-140	Adenosine Receptor	Others
ISAM-140 (22b) is a potent and highly selective **A2B adenosine receptor** antagonist with a K_i of 3.49 nM .

HY-153897

PSB-1901	Adenosine Receptor	Cancer
PSB-1901 is a potent A_2B adenosine receptor (A_2BAR) antagonist with K_is of 0.0835 nM and 0.131 nM for human and mouse A_2BARs respectively. PSB-1901 can be used for the research of cancer .

HY-U00321

A2B receptor antagonist 1	Adenosine Receptor	Inflammation/Immunology Cancer
A2B receptor antagonist 1 is a potent **A2B adenosine receptor** antagonist extracted from patent WO 2009157938 A1 EXAMPLE 9B.

HY-14390

LAS101057 1 Publications Verification	Adenosine Receptor	Inflammation/Immunology
LAS101057 is a potent, selective, and orally efficacious **A2B receptor** antagonist.

HY-129092

8-(p-Sulfophenyl)theophylline 8-SPT; 8-pSPT	Adenosine Receptor	Others
8-(p-Sulfophenyl)theophylline (8-SPT) (compound 2) is an adenosine A2B receptor antagonist, with a K_i of 1330 nM for A2B human recombinant .

HY-111295

LAS38096	Adenosine Receptor	Others
LAS38096 is a potent, selective, and efficacious **A2B Adenosine Receptor** antagonist, with a K_i of 17 nM .

HY-144064

*Adenosine receptor* antagonist 2**	Adenosine Receptor	Cancer
Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC₅₀s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity .

HY-148076

*A2A receptor* antagonist 3**	Adenosine Receptor	Cancer
A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a K_i of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with K_is of 37, 107 and 1467 nM, respectively .

HY-103182A

PSB-1115 potassium salt	Adenosine Receptor	Others
PSB-1115 potassium salt is a selective *A2B* Adenosine Receptor antagonist. PSB-1115 potassium salt inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh) .

HY-14873

Tonapofylline BG 9928	Adenosine Receptor	Cardiovascular Disease Metabolic Disease
Tonapofylline (BG 9928) is an orally active and selective adenosine A₁ receptor antagonist with a K_i of 7.4 nM for human adenosine A₁ receptor (hA₁), which displays 915-fold selectivity versus human adenosine A_2A receptor and 12-fold selectivity versus human adenosine A_2B receptor and is used in development for the treatment of heart failure .

HY-179248

*Adenosine receptor* antagonist 7**	Adenosine Receptor ERK JNK MMP	Cancer
Adenosine receptor antagonist 7 is an orally active triple *A1/A2A/A2B* adenosine receptor antagonist with K_i values of 1.5, 0.6 and 21 nM. Adenosine receptor antagonist 7 shows potent inhibitory activity (IC₅₀ = 0.8 nM) of cAMP production in A2AR-HEK293 cells. Adenosine receptor antagonist 7 can enhance infiltration of effector T cells and increase the CD8+/Treg ratio companied with Avelumab (HY-108730). Adenosine receptor antagonist 7can be used for the research of cancer, such as colon cancer .

HY-103167

CGH2466 dihydrochloride	Adenosine Receptor p38 MAPK Phosphodiesterase (PDE)	Inflammation/Immunology
CGH 2466 dihydrochloride is an orally active adenosine A1, A2B and A3 receptor antagonist with the IC₅₀ values of 19 nM, 21 nM, and 80 nM respectively. CGH 2466 dihydrochloride inhibits p38 MAPK (IC₅₀ = 187~ 400 nM) and phosphodiesterase type 4D (IC₅₀ = 22 nM). CGH 2466 dihydrochloride displays potent anti-inflammatory effects both in vitro and in vivo, and can be used for research on asthma and chronic obstructive pulmonary disease (COPD) .

HY-12709A

ARC 239 dihydrochloride 1 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology
ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist (pK_d values are 5.95, 7.41 and 7.56 at α2A, α2B, and α2C receptors respectively). ARC 239 dihydrochloride binds to CHO cell membranes expressing human recombinant a2A-, a2B- or a2C-adrenoceptor subtypes with pK_is of 5.6, 8.4, and 7.08, respectively .

HY-109718

ATL-801	Adenosine Receptor	Inflammation/Immunology
ATL-801, an **A_2B receptor** selective antagonist, ameliorates murine colitis .

HY-111306

ATL-802	Adenosine Receptor	Metabolic Disease
ATL-802 is a potent adenosine **A_2B receptor** antagonist. ATL-802 is promising for research of diabetes .

HY-14121R

MRS 1754 (Standard)	Adenosine Receptor	Metabolic Disease Inflammation/Immunology
MRS 1754 (Standard) is the analytical standard of MRS 1754. This product is intended for research and analytical applications. MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats .

HY-123038

CVT-5440	Adenosine Receptor	Inflammation/Immunology
CVT-5440 is a xanthine based, selective, high affinity A_2B adenosine receptors (AdoR) antagonist with a K_i of 50 nM (selectivity A₁> 200; A_2A>200; A₃>167). CVT-5440 has the potential for asthma research .

HY-148088A

M1069 free base 1 Publications Verification	Adenosine Receptor	Cancer
M1069 (free base) is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 (free base) counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity .

HY-103182R

PSB-1115 (Standard)	Reference Standards Adenosine Receptor	Others
PSB-1115 (Standard) is the analytical standard of PSB-1115. This product is intended for research and analytical applications. PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh) .

HY-19533R

SCH 58261 (Standard)	Adenosine Receptor	Cancer
SCH 58261 (Standard) is the analytical standard of SCH 58261. This product is intended for research and analytical applications. SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively .

HY-100678R

CGS 15943 (Standard)	Reference Standards Adenosine Receptor PI3K	Inflammation/Immunology Cancer
CGS 15943 (Standard) is the analytical standard of CGS 15943. This product is intended for research and analytical applications. CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .

HY-119191

KF26777 free base	Adenosine Receptor	Neurological Disease
KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an K_i value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and **A2B receptors*, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors*. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma .

HY-183599

MK-1088	Adenosine Receptor	Cancer
MK-1088 is an orally active **A_2A/A_2B adenosine receptor** antagonist with human A_2A K_i of 0.31 nM, human A_2B K_i 5.3 nM. MK-1088 blocks receptor downstream signaling, inhibits CREB phosphorylation and reverses adenosine-mediated immunosuppression. MK-1088 restores TNF−α release and enhances tumor immune surveillance. MK-1088 can be used for the research of cancer^[1].

HY-10081R

GS-6201 (Standard) CVT-6883 (Standard)	Adenosine Receptor Reference Standards	Inflammation/Immunology
GS-6201 (Standard) is the analytical standard of GS-6201 (HY-10081). This product is intended for research and analytical applications. GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22 nM) . GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .

HY-183239

A2AR/A2BR antagonist 2	Adenosine Receptor	Inflammation/Immunology Cancer
A2AR/A2BR antagonist 2 is a dual *A_2A/A_2B* adenosine receptor antagonist with selectivity for the A₁ receptor. A2AR/A2BR antagonist 2 reverses adenosine-mediated T-cell immunosuppression in the tumor microenvironment. A2AR/A2BR antagonist 2 can be used in cancer-related research .

HY-103166R

PSB-603 (Standard)	Reference Standards Adenosine Receptor	Inflammation/Immunology
PSB-603 (Standard) is the analytical standard of PSB-603 (HY-103166). This product is intended for research and analytical applications. PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a K_i value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM .

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A2B receptor antagonist

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