2. GPCR/G Protein
  3. Adenosine Receptor
  4. PSB-1901

PSB-1901 is a potent A2B adenosine receptor (A2BAR) antagonist with Kis of 0.0835 nM and 0.131 nM for human and mouse A2BARs respectively. PSB-1901 can be used for the research of cancer.

For research use only. We do not sell to patients.

PSB-1901

PSB-1901 Chemical Structure

CAS No. : 2332835-02-4

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Based on 1 publication(s) in Google Scholar

PSB-1901 Related Antibodies

Top Publications Citing Use of Products

View All Adenosine Receptor Isoform Specific Products:

View All Isoforms
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

PSB-1901 is a potent A2B adenosine receptor (A2BAR) antagonist with Kis of 0.0835 nM and 0.131 nM for human and mouse A2BARs respectively. PSB-1901 can be used for the research of cancer[1].

IC50 & Target

Ki: 0.0835 nM (human A2BAR), 0.131 nM (mouse A2BAR)[1]
Molecular Weight

573.46

Formula

C24H25BrN6O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C(N1CCC)=O)NC(C3=CC=C(S(=O)(N4CCN(CC4)C5=CC=C(C=C5)Br)=O)C=C3)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (174.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7438 mL 8.7190 mL 17.4380 mL
5 mM 0.3488 mL 1.7438 mL 3.4876 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7438 mL 8.7190 mL 17.4380 mL 43.5950 mL
5 mM 0.3488 mL 1.7438 mL 3.4876 mL 8.7190 mL
10 mM 0.1744 mL 0.8719 mL 1.7438 mL 4.3595 mL
15 mM 0.1163 mL 0.5813 mL 1.1625 mL 2.9063 mL
20 mM 0.0872 mL 0.4360 mL 0.8719 mL 2.1798 mL
25 mM 0.0698 mL 0.3488 mL 0.6975 mL 1.7438 mL
30 mM 0.0581 mL 0.2906 mL 0.5813 mL 1.4532 mL
40 mM 0.0436 mL 0.2180 mL 0.4360 mL 1.0899 mL
50 mM 0.0349 mL 0.1744 mL 0.3488 mL 0.8719 mL
60 mM 0.0291 mL 0.1453 mL 0.2906 mL 0.7266 mL
80 mM 0.0218 mL 0.1090 mL 0.2180 mL 0.5449 mL
100 mM 0.0174 mL 0.0872 mL 0.1744 mL 0.4360 mL
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PSB-1901 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-19012332835-02-4PSB1901PSB 1901Adenosine ReceptorP1 receptorCHO cellanticancerInhibitorinhibitorinhibit

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