A2A receptor antagonist 3
Based on 1 Customer Validation
A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a Ki of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with Kis of 37, 107 and 1467 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.46%
- CAS No.: 2738606-83-0
- Formula: C26H26N6O2
- Molecular Weight:454.52
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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All Adenosine Receptor Isoforms
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Biological Activity
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A2AR 0.4 nM (Ki) |
A2BR 37 nM (Ki) |
A1R 107 nM (Ki) |
A3R 1467 nM (Ki) |
A2A receptor antagonist 3 (Example 92) (24 h) inhibits CD3/CD28 stimulated IL-2 release with an IC50 of 0.004 μM[1].
A2A receptor antagonist 3 (20 min) inhibits pCREB in CD8+T cells in human whole blood with an IC50 of 0.02 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2738606-83-0
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Appearance Solid
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Molecular Weight 454.52
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Formula C26H26N6O2
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Color Light yellow to yellow
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SMILES
CC(C)(O)[C@H](C)NC(C1=NC2=C(C3=CC(C)=NC(C)=C3)C(C4=CC(C#N)=CC=C4)=NN2C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (55.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2001 mL | 11.0006 mL | 22.0012 mL | 55.0031 mL |
| 5 mM | 0.4400 mL | 2.2001 mL | 4.4002 mL | 11.0006 mL | |
| 10 mM | 0.2200 mL | 1.1001 mL | 2.2001 mL | 5.5003 mL | |
| 15 mM | 0.1467 mL | 0.7334 mL | 1.4667 mL | 3.6669 mL | |
| 20 mM | 0.1100 mL | 0.5500 mL | 1.1001 mL | 2.7502 mL | |
| 25 mM | 0.0880 mL | 0.4400 mL | 0.8800 mL | 2.2001 mL | |
| 30 mM | 0.0733 mL | 0.3667 mL | 0.7334 mL | 1.8334 mL | |
| 40 mM | 0.0550 mL | 0.2750 mL | 0.5500 mL | 1.3751 mL | |
| 50 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.1001 mL |
A2A receptor antagonist 3 Related Classifications
HY-148076 Related Classifications
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