1. GPCR/G Protein
  2. Adenosine Receptor
  3. A2A receptor antagonist 3

A2A receptor antagonist 3 

Cat. No.: HY-148076
Handling Instructions

A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a Ki of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with Kis of 37, 107 and 1467 nM, respectively.

For research use only. We do not sell to patients.

A2A receptor antagonist 3 Chemical Structure

A2A receptor antagonist 3 Chemical Structure

CAS No. : 2738606-83-0

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Description

A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a Ki of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with Kis of 37, 107 and 1467 nM, respectively[1].

IC50 & Target[1]

A2AR

0.4 nM (Ki)

A2BR

37 nM (Ki)

A1R

107 nM (Ki)

A3R

1467 nM (Ki)

In Vitro

A2A receptor antagonist 3 (Example 92) (24 h) inhibits CD3/CD28 stimulated IL-2 release with an IC50 of 0.004 μM[1].
A2A receptor antagonist 3 (20 min) inhibits pCREB in CD8+T cells in human whole blood with an IC50 of 0.02 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

454.52

Formula

C26H26N6O2

CAS No.
SMILES

CC(C)(O)[[email protected]](C)NC(C1=NC2=C(C3=CC(C)=NC(C)=C3)C(C4=CC(C#N)=CC=C4)=NN2C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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A2A receptor antagonist 3
Cat. No.:
HY-148076
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