A2A receptor antagonist 3

Name: A2A receptor antagonist 3
Brand: MedChemExpress
SKU: HY-148076
Rating: 4.5 (0 reviews)

Cat. No.: HY-148076 Purity: 99.46%: Data Sheet
COA

SDS
Handling Instructions
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A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a K_i of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with K_is of 37, 107 and 1467 nM, respectively.

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A2A receptor antagonist 3 Chemical Structure

CAS No. : 2738606-83-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Adenosine Receptor Isoform Specific Products:

View All Isoforms

Adenosine A₁ receptor (A₁R) Adenosine A_2A receptor (A_2AR) Adenosine A_2B receptor (A_2BR) Adenosine A₃ receptor (A₃R)

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

A2AR

0.4 nM (Ki)

A2BR

37 nM (Ki)

A1R

107 nM (Ki)

A3R

1467 nM (Ki)

In Vitro

A2A receptor antagonist 3 (Example 92) (24 h) inhibits CD3/CD28 stimulated IL-2 release with an IC₅₀ of 0.004 μM^[1].
A2A receptor antagonist 3 (20 min) inhibits pCREB in CD8+T cells in human whole blood with an IC₅₀ of 0.02 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

454.52

Formula

C₂₆H₂₆N₆O₂

CAS No.

2738606-83-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C)(O)[C@H](C)NC(C1=NC2=C(C3=CC(C)=NC(C)=C3)C(C4=CC(C#N)=CC=C4)=NN2C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (55.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2001 mL	11.0006 mL	22.0012 mL
5 mM	0.4400 mL	2.2001 mL	4.4002 mL
10 mM	0.2200 mL	1.1001 mL	2.2001 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.46%

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Data Sheet (272 KB) SDS (252 KB)

COA (251 KB) HNMR (190 KB) NP-HPLC (132 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Clive Mccarthy, et al. Antagonists of the adenosine a2a receptor. Patent WO2021224636 A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2001 mL	11.0006 mL	22.0012 mL	55.0031 mL
	5 mM	0.4400 mL	2.2001 mL	4.4002 mL	11.0006 mL
	10 mM	0.2200 mL	1.1001 mL	2.2001 mL	5.5003 mL
	15 mM	0.1467 mL	0.7334 mL	1.4667 mL	3.6669 mL
	20 mM	0.1100 mL	0.5500 mL	1.1001 mL	2.7502 mL
	25 mM	0.0880 mL	0.4400 mL	0.8800 mL	2.2001 mL
	30 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8334 mL
	40 mM	0.0550 mL	0.2750 mL	0.5500 mL	1.3751 mL
	50 mM	0.0440 mL	0.2200 mL	0.4400 mL	1.1001 mL