1. GPCR/G Protein
  2. Adenosine Receptor
  3. PSB-1115

PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh).

For research use only. We do not sell to patients.

PSB-1115 Chemical Structure

PSB-1115 Chemical Structure

CAS No. : 152529-79-8

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Description

PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1].

IC50 & Target[1]

A2BR

 

In Vitro

PSB-1115 (100 μM) inhibits TNBS (10 mM) induced ACh contraction inhibition in the ileum/jejunum segment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PSB-1115 (0.5 mg/kg; i.p.; single dose, injected 20 minutes before inhalation) antagonizes the inhibitory effect of the non-selective adenosine receptor agonist NECA (HY-103173) on mucociliary clearance in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

350.35

Formula

C14H14N4O5S

CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=S(C1=CC=C(C2=NC3=C(NC(N(CCC)C3=O)=O)N2)C=C1)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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PSB-1115 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PSB-1115
Cat. No.:
HY-103182
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