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Aurora-A kinase

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By Targets:	Aurora Kinase (12) Apoptosis (7) Bcr-Abl (1) c-Kit (1) c-Myc (1) CDK (2) EGFR (1) FLT3 (1) G Protein-coupled Receptor Kinase (GRK) (1) Glycosidase (1) Histone Methyltransferase (1) Mitosis (1) MMP (1) PROTACs (1) Reference Standards (1) TAM Receptor (1) Tie (1) VEGFR (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Metabolic Disease (1)

13

Inhibitors & Agonists

2

Natural
Products

1

Recombinant Proteins

3

Antibodies

Targets Recommended: Aurora Kinase

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

LY3295668 3 Publications Verification AK-01	Aurora Kinase Apoptosis	Cancer
LY3295668 (AK-01) is a highly specific and orally active inhibitor of **Aurora-A kinase with a K_i values for AurA and AurB of 0.8 nM and 1038 nM respectively. LY3295668 can effectively inhibit the autophosphorylation of AurA, induce mitotic arrest and apoptosis**. LY3295668 avoids the formation of polyploids related to AurB inhibition. LY3295668 can be used for the study of small cell lung cancer .

JNJ-7706621 5 Publications Verification	Aurora Kinase CDK Apoptosis	Cancer
JNJ-7706621 is a potent **aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC₅₀s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A and aurora-B**, respectively .

Quercimeritrin 2 Publications Verification Quercetin-7-O-β-D-glucopyranoside	Glycosidase c-Kit MMP VEGFR Aurora Kinase	Metabolic Disease Cancer
Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor (with an IC₅₀ of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer .

GRK2 Inhibitor 2 1 Publications Verification	Aurora Kinase G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
GRK2 Inhibitor 2 is an orally active and selective G protein-coupled receptor kinase 2 (GRK) inhibitor with an IC₅₀ of 19 nM. GRK2 Inhibitor 2 also inhibits *Aurora-A* with an IC₅₀ of 137 nM. GRK2 Inhibitor 2 can be used in the study of congestive heart failure (HF) .

JB170 3 Publications Verification	PROTACs Aurora Kinase	Cancer
JB170 is a potent and highly specific PROTAC-mediated *AURORA-A* (Aurora *Kinase) degrader (DC₅₀=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A* (EC₅₀=193 nM) over AURORA-B (EC₅₀=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase .

CCT241736	FLT3 Aurora Kinase	Cancer
CCT241736 is a potent and orally bioavailable dual FLT3 and **Aurora kinase** inhibitor, which inhibits Aurora kinases (Aurora-A K_d, 7.5 nM, IC₅₀, 38 nM; Aurora-B K_d, 48 nM), FLT3 kinase (K_d, 6.2 nM), and FLT3 mutants including FLT3-ITD (K_d, 38 nM) and FLT3(D835Y) (K_d, 14 nM).

Phthalazinone pyrazole	Aurora Kinase Apoptosis Mitosis	Cancer
Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC₅₀ of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells .

Corylifol C	EGFR TAM Receptor Tie	Cancer
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

PHA-680626	Aurora Kinase c-Myc Bcr-Abl Histone Methyltransferase Apoptosis	Cancer
PHA-680626 is an effective inhibitor of the interaction between *Aurora-A* and N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib (HY-15463)-resistant chronic myeloid leukemia cell lines and primary CD34+ cells .

Aurora A inhibitor 3	Aurora Kinase	Cancer
Aurora A inhibitor 3 (Compound 5h) inhibits Aurora-A kinase with an IC₅₀ value of 0.78 μM. Aurora A inhibitor 3 is cytotoxic, with GI₅₀ values of 0.12 μM and 0.63 μM for MCF-7 and MDA-MB-231 cells, respectively .

ATC12	Aurora Kinase Apoptosis	Cancer
ATC12 is a *Aurora-A* kinase inhibitor. ATC12 binds to *Aurora-A* and competes with TPX2 for binding to disrupt the *Aurora-A/TPX2* interaction. ATC12 inhibits cancer cell proliferation, induces apoptosis and cellular senescence. ATC12 can be used in the research of breast cancer .

JNJ-7706621 (Standard)	Reference Standards Aurora Kinase CDK Apoptosis	Cancer
JNJ-7706621 (Standard) is the analytical standard of JNJ-7706621 (HY-10329). This product is intended for research and analytical applications. JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC₅₀s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A and aurora-B, respectively .

LY3295668 erbumine AK-01 erbumine	Aurora Kinase Apoptosis	Cancer
LY3295668 (AK-01) erbumine is a highly specific and orally active inhibitor of **Aurora-A kinase with a K_i values for AurA and AurB of 0.8 nM and 1038 nM respectively. LY3295668 erbumine can effectively inhibit the autophosphorylation of AurA, induce mitotic arrest and apoptosis**. LY3295668 erbumine avoids the formation of polyploids related to AurB inhibition. LY3295668 erbumine can be used for the study of small cell lung cancer .

Art. -Nr.	Compare	Produktname	Species	Source	Image

	AURKA Protein, Human (Inactive, sf9) AURKA; Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Aurora-A	Human	Sf9 insect cells

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Source
Tag
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Gene ID
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Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3) Monkey (2)
Application:	IHC-P (1) ICC/IF (3) IP (1) WB (3) ELISA (1)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Art. -Nr.	Compare	Produktname	Application	Reactivity	Image

	Aurora A Antibody (YA827) AIK; ARK1; AYK1; Aurora-A; Aurora-related kinase 1; BTAK; IAK1; Ipl1- and Aurora-related kinase 1; STK15; STK6; Serine/threonine kinase 15	WB, ICC/IF	Human, Monkey
	Aurora A Antibody (YA827) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Aurora A.

	Aurora A Antibody (YA827)(PBS only) AIK; ARK1; AYK1; Aurora-A; Aurora-related kinase 1; BTAK; IAK1; Ipl1- and Aurora-related kinase 1; STK15; STK6; Serine/threonine kinase 15	WB, ICC/IF	Human, Monkey
	Aurora A Antibody (YA827) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Aurora A.

	Aurora A Antibody (YA6333) Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Aurora-A;	WB, IHC-P, ICC/IF, IP, ELISA	Human
	Aurora A Antibody (YA6333) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aurora A.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / Auf Lager - + In den Warenkorb hinzufügen Angebot einholen

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