253-52-1
253-52-1
Chemical Structure
Phthalazine
- CAS No.: 253-52-1
- Formula:C8H6N2
- Molecular Weight:130.15
IUPAC Name: phthalazine
InChIKey: LFSXCDWNBUNEEM-UHFFFAOYSA-N
SMILES: C12=CC=CC=C1C=NN=C2
Biological Activity: Phthalazine is a chemical scaffold. Phthalazine derivatives act as VEGFR-2 inhibitors, PARP-1 inhibitors, and anticancer agents. The complex of phthalazine with silver exhibits broad-spectrum antibacterial and antifungal activities against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa PAO1, and Candida albicans. Phthalazine derivatives possess potent vasodilatory activity. Phthalazine can be used in research related to colon adenocarcinoma, breast cancer, hypertension, diabetes, and microbial infections[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phthalazine | 99.98% | Phthalazine is a chemical scaffold. Phthalazine derivatives act as VEGFR-2 inhibitors, PARP-1 inhibitors, and anticancer agents. The complex of phthalazine with silver exhibits broad-spectrum antibacterial and antifungal activities against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa PAO1, and Candida albicans. Phthalazine derivatives possess potent vasodilatory activity. Phthalazine can be used in research related to colon adenocarcinoma, breast cancer, hypertension, diabetes, and microbial infections. | ||||||||||||||||||||
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Phthalazine (Standard) | ≥98% | Phthalazine (Standard) is the analytical standard of Phthalazine. This product is intended for research and analytical applications. Phthalazine is a substrate for human aldehyde oxidase 1, which can lead to the production of ROS and subsequent enzyme inactivation. Phthalazine is a nitrogen-containing organic heterocyclic compound. Phthalazine exhibits antitumor activity in blood cancer, breast cancer, colon cancer, lung cancer and renal cancer. | ||||||||||||||||||||
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4-Bromoisoquinoline | 98.68% | 4-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Indazole (Standard) | ≥98% | Indazole (Standard) is the analytical standard of Indazole. This product is intended for research and analytical applications. Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases. | ||||||||||||||||||||
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6-Bromoisoquinoline | 98.18% | 6-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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1,8-Naphthyridine | 1,8-Naphthyridine is a heterocyclic compound with antibacterial and antitumor activities. 1,8-Naphthyridine is promising for research of antibacterial agents and cancers. | |||||||||||||||||||||
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Isoquinolin-4-amine | 99.97% | Isoquinolin-4-amine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Isoquinoline (Standard) | ≥98% | Isoquinoline (Standard) is the analytical standard of Isoquinoline. This product is intended for research and analytical applications. Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities. | ||||||||||||||||||||
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Isoquinoline-15N | Isoquinoline-15N is the 15N-labeled Isoquinoline (HY-W012732). Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities. | |||||||||||||||||||||
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3-Methylquinoline | 98.86% | 3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC50 of 13 μM. 3-Methylquinoline can reduce the metabolic clearance of CYP1A2 substrate drugs. 3-Methylquinoline can inhibit the activation of carcinogenic precursors. | ||||||||||||||||||||
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3,3'-Bipyridine | 3,3'-Bipyridine (3,3'-Dipyridyl) is a ligand used in coordination chemistry. 3,3'-Bipyridine can combine with BINOL to facilitate catalytic reactions. | |||||||||||||||||||||
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References
- [1]. El-Helby AA, et al. Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR-2 Inhibitors. Arch Pharm (Weinheim). 2017 Dec;350(12). [Content Brief]
- [2]. Sangshetti J, et al. Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review. Bioorganic & medicinal chemistry. 2019 Sep 15;27(18):3979-3997. [Content Brief]
