3115765-45-9
3115765-45-9
Chemical Structure
dAurAB5
- CAS No.: 3115765-45-9
- Formula:C42H49N11O7
- Molecular Weight:819.91
InChIKey: HRCOTHKLMILKBW-UHFFFAOYSA-N
SMILES: O=C(NCCCCCC(N1CCN(C2=CC=C(NC3=NC(NC4CCCCC4)=C5N=CNC5=N3)C=C2)CC1)=O)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O
Biological Activity: dAurAB5 is a potent Aurora-A/Aurora-B PROTAC degrader with DC50 values of 8.8 nM and 6.1 nM, respectively. dAurAB5 promotes proteasomal degradation of target proteins, induces ubiquitination of Aurora-A and Aurora-B kinases, and downregulates the protein levels of TTK and MYCN. dAurAB5 can be used in studies related to neuroblastoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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dAurAB5 | 99.03% | dAurAB5 is a potent Aurora-A/Aurora-B PROTAC degrader with DC50 values of 8.8 nM and 6.1 nM, respectively. dAurAB5 promotes proteasomal degradation of target proteins, induces ubiquitination of Aurora-A and Aurora-B kinases, and downregulates the protein levels of TTK and MYCN. dAurAB5 can be used in studies related to neuroblastoma. | ||||||||||||||||||||
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