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Results for "

COX-2-IN-5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) Autophagy (2) Bacterial (2) Beta-secretase (1) Cholinesterase (ChE) (2) COX (19) Enterovirus (2) ERK (4) GABA Receptor (1) HIF/HIF Prolyl-Hydroxylase (2) Keap1-Nrf2 (4) Leukotriene Receptor (2) Lipoxygenase (15) LOX-1 (2) Monoamine Oxidase (2) NF-κB (2) Notch (2) Opioid Receptor (1) p38 MAPK (2) Parasite (1) PGE synthase (2) PI3K (2) Pyruvate Kinase (2) Reactive Oxygen Species (ROS) (2) Reference Standards (5) Virus Protease (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (18) Metabolic Disease (3) Neurological Disease (7)

By Targets:

Apoptosis (4)

Autophagy (2)

Bacterial (2)

Beta-secretase (1)

Cholinesterase (ChE) (2)

COX (19)

Enterovirus (2)

ERK (4)

GABA Receptor (1)

HIF/HIF Prolyl-Hydroxylase (2)

Keap1-Nrf2 (4)

Leukotriene Receptor (2)

Lipoxygenase (15)

LOX-1 (2)

Monoamine Oxidase (2)

NF-κB (2)

Notch (2)

Opioid Receptor (1)

p38 MAPK (2)

Parasite (1)

PGE synthase (2)

PI3K (2)

Pyruvate Kinase (2)

Reactive Oxygen Species (ROS) (2)

Reference Standards (5)

Virus Protease (2)

By Research Areas:

Cancer (6)

Cardiovascular Disease (2)

Infection (2)

Inflammation/Immunology (18)

Metabolic Disease (3)

Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0232

Psoralidin 5 Publications Verification	COX Lipoxygenase Notch Reactive Oxygen Species (ROS) Bacterial	Cancer
Psoralidin is a dual inhibitor of *COX-2* and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation .

HY-N7108

7-Hydroxyflavone 1 Publications Verification	ERK Keap1-Nrf2 Apoptosis COX Pyruvate Kinase Lipoxygenase Enterovirus Virus Protease	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC₅₀ of 2.12 μM. 7-Hydroxyflavone inhibits *COX-2* and 5-LOX with IC₅₀ of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active .

HY-N0493

Pectolinarigenin 2 Publications Verification	COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Pectolinarigenin is an orally active dual inhibitor of *COX-2/5-LOX* with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of *COX-2, 5-LOX* and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G₂/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma .

HY-N1942

5-O-Demethylnobiletin 3 Publications Verification 5-DemethylnobiletIN	Lipoxygenase Leukotriene Receptor	Neurological Disease Inflammation/Immunology Cancer
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB₄) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-10439

HPGDS inhibitor 1	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC₅₀s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .

HY-116947

*COX-2-IN-5*	COX	Inflammation/Immunology
COX-2-IN-5 (compound 11a) is a potent COX-2 inhibitor with an IC₅₀ value of 0.65 µM. COX-2-IN-5 has the potential for the research of inflammation .

HY-170938

AChE-IN-82	Cholinesterase (ChE) Monoamine Oxidase Beta-secretase COX LOX-1	Neurological Disease
AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC₅₀s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, *COX-2* and 5-LOX with IC₅₀s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H₂ O₂ .

HY-116763

COX-2/5-LOX-IN-4	COX LOX-1
COX-2/5-LOX-IN-4 (Compound 1) is a dual inhibitor that acts on both *COX-2* and 5-LOX, with IC₅₀ values of 0.05 μM for COX-2 and 0.003 μM for 5-LOX. By inhibiting the arachidonic acid metabolism pathway, COX-2/5-LOX-IN-4 reduces the production of prostaglandins and leukotrienes, alleviating inflammatory responses. In a rat ear edema model, intravenous administration (0.01 and 0.1 mg/kg) reduced edema by 41% and 44%, respectively, demonstrating significant anti-inflammatory effects. COX-2/5-LOX-IN-4 shows promise for studying the mechanisms of inflammatory diseases .

HY-W028263

6-Hydroxyflavanone	COX Opioid Receptor GABA Receptor Lipoxygenase	Metabolic Disease Inflammation/Immunology
6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes .

HY-19212

S-2474	COX Lipoxygenase	Inflammation/Immunology
S-2474 is an inhibitor of *COX-2* and 5-lipoxygenase (5-LO), with IC₅₀s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.

HY-N7108R

7-Hydroxyflavone (Standard)	Reference Standards ERK Keap1-Nrf2 Apoptosis COX Pyruvate Kinase Lipoxygenase Enterovirus Virus Protease	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
7-Hydroxyflavone (Standard) is the analytical standard of 7-Hydroxyflavone. This product is intended for research and analytical applications. 7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC₅₀ of 2.12 μM. 7-Hydroxyflavone inhibits *COX-2* and 5-LOX with IC₅₀ of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active .

HY-172790

Cbz-(S,S)-Pro-Pro-allyl	COX Lipoxygenase	Inflammation/Immunology
Cbz-(S,S)-Pro-Pro-allyl (compound 1a) is a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase with IC₅₀ values of 0.146 nM, 0.003 nM, 0.64 nM for COX-1, COX-2, 5-LOX, respectively. Cbz-(S,S)-Pro-Pro-allyl has anti-inflammatory activity .

HY-U00022

RWJ 63556	COX Lipoxygenase	Inflammation/Immunology
RWJ 63556 is an orally active *COX-2 selective/5-lipoxygenase* inhibitor, with anti-inflammatory activities.

HY-N12708

23-O-β-D-Glucopyranosyl-20-isoveratramine	Others	Others
23-O-β-D-Glucopyranosyl-20-isoveratramine is a potential anti-allergic agent extracted from nettles. A variety of COX-1, COX-2, 5-lipoxygenase and trypsin-like inhibitors and H1 antagonists are found in nettle extract, which can inhibit seasonal allergies, allergic rhinitis and other inflammatory diseases. and preventive effects .

HY-N1942R

5-O-Demethylnobiletin (Standard) 5-DemethylnobiletIN (Standard)	Reference Standards Lipoxygenase Leukotriene Receptor	Neurological Disease Inflammation/Immunology Cancer
5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-162523

hMAO-B-IN-8	Monoamine Oxidase Cholinesterase (ChE) COX Lipoxygenase	Neurological Disease
hMAO-B-IN-8 (Compound 23) is a hMAO-B, eeAChE, *COX-2* and 5-LOX inhibitor, with IC₅₀ values of 0.037 μM, 0.071 μM, 14.3 μM and 0.59 μM, respectively. hMAO-B-IN-8 can be used for the research of Alzheimer's disease .

HY-113807

ZLJ-6	COX Lipoxygenase	Inflammation/Immunology
ZLJ-6 is a dual COX and 5-LOX inhibitor with oral activity. The IC₅₀ values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity .

HY-N0232R

Psoralidin (Standard)	Reference Standards COX Lipoxygenase Notch Reactive Oxygen Species (ROS) Bacterial	Cancer
Psoralidin (Standard) is the analytical standard of Psoralidin. This product is intended for research and analytical applications. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation .

HY-147951

COX-2/5-LOX-IN-3	COX Lipoxygenase	Inflammation/Immunology
COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual *COX-2/5-LOX* inhibitor with IC₅₀ values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases .

HY-N0493R

Pectolinarigenin (Standard)	Reference Standards COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy	Inflammation/Immunology
Pectolinarigenin (Standard) is the analytical standard of Pectolinarigenin. This product is intended for research and analytical applications. Pectolinarigenin is an orally active dual inhibitor of *COX-2/5-LOX* with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of *COX-2, 5-LOX* and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G₂/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma.

HY-146295

COX-2/5-LOX-IN-2	COX	Inflammation/Immunology
COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of *COX-2/5-LOX*. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 5.40, 0.01 and 1.78 μM, respectively .

HY-146294

COX-2/5-LOX-IN-1	COX	Inflammation/Immunology
COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of *COX-2/5-LOX*. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 12.13, 0.4 and 4.96 μM, respectively .

HY-10439R

HPGDS inhibitor 1 (Standard)	Reference Standards PGE synthase	Inflammation/Immunology
HPGDS inhibitor 1 (Standard) is the analytical standard of HPGDS inhibitor 1 (HY-10439). This product is intended for research and analytical applications. HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC₅₀s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .

HY-W676872

Dihydroflavokawin B	COX Parasite	Infection Inflammation/Immunology
Dihydroflavokawin B is a selective COX-1 inhibitor with an IC₅₀ of 1.22 μM. Dihydroflavokawin B weakly inhibits COX-2 and 5-LOX. Dihydroflavokawin B inhibits promastigote forms of Leishmania panamensis and Leishmania braziliensis. Dihydroflavokawin B inhibits rabbit platelet aggregation induced by Arachidonic acid, platelet activating factor, and adenosine diphosphate. Dihydroflavokawin B exhibits in vitro anti-inflammatory activity. Dihydroflavokawin B can be used for the research of leishmaniasis .

Cat. No.	Product Name	Category	Target	Chemical Structure