6665-86-7
Chemical Structure
7-Hydroxyflavone
- CAS No.: 6665-86-7
- Formula:C15H10O3
- Molecular Weight:238.24
IUPAC Name: 7-hydroxy-2-phenyl-4H-chromen-4-one
InChIKey: MQGPSCMMNJKMHQ-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=CC=C13
Biological Activity: 7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active[1][2][4].
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7-Hydroxyflavone | 99.89% | 7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active. | ||||||||||||||||||||
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7-Hydroxyflavone (Standard) | ≥98% | 7-Hydroxyflavone (Standard) is the analytical standard of 7-Hydroxyflavone. This product is intended for research and analytical applications. 7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active. | ||||||||||||||||||||
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Similarity Score 0.91
HY-N71106-Hydroxyflavone -
Similarity Score 0.87
HY-N8487R7-Methoxyflavone (Standard) -
Similarity Score 0.85
HY-W3190944′-Hydroxyflavone -
Similarity Score 0.85
HY-N2609R7,4'-Dihydroxyflavone (Standard) -
Similarity Score 0.84
HY-220245-Hydroxyflavone -
Similarity Score 0.84
HY-1271686,7-Dihydroxyflavone -
Similarity Score 0.84
HY-N2424Flavone -
Similarity Score 0.83
HY-N66306-Methylflavone -
Similarity Score 0.82
HY-14589Chrysin -
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References
- [1]. Vinutha K, et al. Aqueous extract from Madhuca indica bark protects cells from oxidative stress caused by electron beam radiation: in vitro, in vivo and in silico approach. Heliyon. 2019 May 30;5(5):e01749. [Content Brief]
- [2]. Sengupta B, et al. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017 Jun 22;12(6):e0179777. [Content Brief]
