1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. 6-Methylflavone

6-Methylflavone 

Cat. No.: HY-N6630 Purity: 99.49%
Handling Instructions

6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.

For research use only. We do not sell to patients.

6-Methylflavone Chemical Structure

6-Methylflavone Chemical Structure

CAS No. : 29976-75-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.

IC50 & Target

α1β2γ2L GABAA receptor, α1β2 GABAA receptor[1]

In Vitro

6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone enhances the normal response to GABA at recombinant α1β2γ2L and α1β2 GABAA receptors (P<0.0001) at concentrations from 1 to 100 μM. 6-Methylflavone (60 μM) shifts the GABA dose-response curve to the left (n=4, F=16.38, P=0.0004), decreasing the mean EC50 at α1β2γ2L GABAA receptors by 33±5.4%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

236.27

Formula

C₁₆H₁₂O₂

CAS No.
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC=C(C)C=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (211.62 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2324 mL 21.1622 mL 42.3245 mL
5 mM 0.8465 mL 4.2324 mL 8.4649 mL
10 mM 0.4232 mL 2.1162 mL 4.2324 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

6-MethylflavoneGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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Product Name:
6-Methylflavone
Cat. No.:
HY-N6630
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