Search Result

Isoforms Recommended:	CYP1

Results for "

CYP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5-HT Receptor (5) Adrenergic Receptor (1) Akt (2) AMPK (1) Androgen Receptor (3) Antibiotic (2) Apoptosis (10) Aryl Hydrocarbon Receptor (28) Autophagy (3) Bacterial (8) Bcl-2 Family (1) Biochemical Assay Reagents (3) Calcium Channel (3) Caspase (3) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (2) COX (8) CRFR (1) Cytochrome P450 (126) DNA/RNA Synthesis (2) Drug Intermediate (1) Drug Metabolite (9) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (11) Environmental Pollutants (5) ERK (3) Estrogen Receptor/ERR (3) Ferroptosis (1) Fungal (3) GABA Receptor (5) Glycosidase (1) HBV (2) HIV (1) IFNAR (1) Influenza Virus (2) Insecticide (1) Interleukin Related (2) Isotope-Labeled Compounds (11) Keap1-Nrf2 (1) Ligands for Target Protein for PROTAC (1) Lipoxygenase (1) MDM-2/p53 (2) mGluR (1) MMP (1) mTOR (1) NF-κB (4) NO Synthase (2) P-glycoprotein (2) Parasite (3) PARP (1) PI3K (1) Potassium Channel (4) PROTAC Linkers (1) PROTACs (2) Proton Pump (1) Quinone Reductase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (28) RET (1) Ribosomal S6 Kinase (RSK) (1) ROCK (1) SARS-CoV (1) Small Interfering RNA (siRNA) (11) STAT (1) STING (1) TGF-beta/Smad (1) Thyroid Hormone Receptor (3) URAT1 (1) VEGFR (1) α-synuclein (1) β-catenin (1) β-glucuronidase (1)
By Research Areas:	Cancer (75) Cardiovascular Disease (6) Endocrinology (3) Infection (19) Inflammation/Immunology (27) Metabolic Disease (27) Neurological Disease (29)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (4) siRNAs (10)

187

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0125

Diosmetin Maximum Cited Publications 20 Publications Verification	Cytochrome P450	Cancer
Diosmetin is a natural flavonoid which inhibits human *CYP1A* enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-B0476

Phenacetin 1 Publications Verification Acetophenetidin	COX	Inflammation/Immunology
Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats ^[1] .

HY-N0382

Galangin 15+ Cited Publications Norizalpinin; 3,5,7-Trihydroxyflavone	Cytochrome P450 Autophagy	Cancer
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of *CYP1A1* activity.

HY-N2194

Bergamottin 5+ Cited Publications 5-Geranoxypsoralen; Bergamotine; Bergaptin	Cytochrome P450	Cancer
Bergamottin is a potent and competitive *CYP1A1* inhibitor with a K_i of 10.703 nM.

HY-B1234

Octinoxate Octyl methoxycinnamate	Environmental Pollutants Estrogen Receptor/ERR Androgen Receptor Cytochrome P450 Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits *CYP1A1* and *CYP1B1* to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo ^[1] .

HY-B0973

Dibenzothiophene DBT; Diphenylene sulfide	Cytochrome P450 Aryl Hydrocarbon Receptor	Metabolic Disease
Dibenzothiophene is an orally active and a noncompetitive *CYP1A* inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with a K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms ^[1] .

HY-Y0110

2-Naphthol 1 Publications Verification	Environmental Pollutants Endogenous Metabolite	Others
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-19340

TMS 5+ Cited Publications (E)-2,3',4,5'-tetramethoxystilbene	Cytochrome P450	Cancer
TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive *CYP1B1* inhibitor with an IC₅₀ of 6 nM and a K_i value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC₅₀=300 nM) and CYP1A2 (IC₅₀=3.1 μM). TMS is a methylated derivative of resveratrol and has anti-cancer activity ^[1] .

HY-134217

KYN-101	Aryl Hydrocarbon Receptor	Cancer
KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity ^[1].

HY-N2374

Eupatorin 2 Publications Verification	Apoptosis NF-κB MMP Adrenergic Receptor	Inflammation/Immunology Cancer
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. Eupatorin downregulates the expression levels of NF-κB, MMP9, *IL-1β* and TNF-α. Eupatorin induces apoptosis, G2/M phase cell cycle arrest, and reactive oxygen species (ROS) production. Eupatorin modulates the activities of muscarinic receptors and β-adrenergic receptors; inhibits sarcoplasmic reticulum calcium release and calcium channels; and activates the NO/sGC/cGMP pathway, indomethacin-sensitive pathway, and potassium channel pathway. Eupatorin exerts cytotoxic effects on cancer cell lines, and is metabolized by *CYP1A1* and CYP1 family enzymes to form metabolites with antiproliferative activity. Eupatorin can be used in research related to breast cancer, hypertension, and leukemia ^[1] .

HY-D0145

7-Ethoxyresorufin 1 Publications Verification Resorufin ethyl ether	Cytochrome P450 NO Synthase	Others
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially *CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase* ^[1] .

HY-D0932

Sudan IV Solvent Red 24; C.I. 26105	Environmental Pollutants Biochemical Assay Reagents Cytochrome P450 Aryl Hydrocarbon Receptor	Metabolic Disease
Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces *CYP1A1* expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections ^[1] .

HY-N5132

(-)-Fenchone	Cytochrome P450	Others
(-)-Fenchone is a bicyclic monoterpene and serves as a substrate for human liver microsomal cytochrome P450 enzymes *CYP2A6* and *CYP2B6. (-)-Fenchone is not metabolized by human CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4 enzymes. (-)-Fenchone undergoes hydroxylation to produce 6-exo-hydroxyfenchone, 6-endo-hydroxyfenchone, and 10-hydroxyfenchone. During the metabolism of (-)-Fenchone, CYP2A6 may play a more important role than CYP*2B6 ^[1].

HY-117102

ANI-7	Aryl Hydrocarbon Receptor Checkpoint Kinase (Chk)	Cancer
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI₅₀ of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines ^[1] .

HY-152118

CYP1B1-IN-4	Cytochrome P450	Cancer
CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively *CYP1B1* inhibition (IC₅₀=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes ^[1].

HY-120377

CYP1A1 inhibitor 8a	HBV	Cancer
CYP1A1 inhibitor 8a is a compound that potently and selectively inhibits the CYP1A1 enzyme and has the potential to prevent cancer. CYP1A1 inhibitor 8a exhibits more than 10-fold selectivity for CYP1A1 and more than 100-fold selectivity over other enzymes in the CYP1 subfamily. CYP1A1 inhibitor 8a can effectively antagonize B[a]P-mediated activation of the aryl hydrocarbon receptor (AhR) in yeast cells and protect human cells from CYP1A1-mediated B[a]P toxicity. CYP1A1 inhibitor 8a has the potential to be developed as a cancer chemopreventive agent ^[1].

HY-101285

DMU2139 1 Publications Verification	Cytochrome P450	Cancer
DMU2139 is a potent and specific *CYP1B1* inhibitor, with IC₅₀s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.

HY-Y0110S1

2-Naphthol-d7	Endogenous Metabolite	Others
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol ^[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-W007700

8-Bromooctanoic acid	PROTAC Linkers	Cancer
8-Bromooctanoic acid is a PROTAC linker, and can be used for synthesis of PROTAC CYP1B1 degrader-2 (HY-158429) ^[1].

HY-N2625A

Harmalol hydrochloride	Cytochrome P450	Cancer
Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties ^[1].

HY-157942

CYP1B1-IN-7	Cytochrome P450	Cancer
CYP1B1-IN-7 (compound 2a) is a selective inhibitor of CYP1B1 (IC₅₀: 75 nM). CYP1B1-IN-7 also reverses resistance (IC₅₀: 29 μM) and exhibits cytotoxicity in the CYP1B1-overexpressing MCF-7 cell line that is resistant to Docetaxel (HY-B0011) ^[1].

HY-159006

CYP1B1 ligand 3	Cytochrome P450	Cancer
CYP1B1 ligand 3 (Compound A1) is a selective inhibitor for cytochrome P450 enzyme *CYP1B1* with an IC₅₀ of 11.9 nM. CYP1B1 ligand 3 can be utilized for the synthesis of PROTAC CYP1B1 degrader-2 (HY-158429) ^[1].

HY-W008003

2-Hydroxybenzimidazole	Cytochrome P450	Others
2-Hydroxybenzimidazole is an inactive compound targeting *CYP1A1* and is mainly used as a control compound in the structure-activity relationship study of benzimidazole derivatives. 2-Hydroxybenzimidazole does not have the ability to induce CYP1A1 expression like its thiol or amino substituted derivatives ^[1].

HY-103223

Phortress NSC 710305	Cytochrome P450	Cancer
Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1 ^[1] .

HY-W045990

2,7-Dimethylnaphthalene	Cytochrome P450	Metabolic Disease
2,7-Dimethylnaphthalene is a selective cytochrome P450 1A2 (CYP1A2) enzyme inhibitor with an IC₅₀ of 65 μM. 2,7-Dimethylnaphthalene can be used for the research of metabolic disease ^[1].

HY-N8382

Chalepensin	Cytochrome P450 Parasite Insecticide	Infection
Chalepensin is a nematicide and *CYP* inhibitor. Chalepensin inhibits *CYP2A6, CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4* to varying degrees, with IC₅₀ values of 82.3 μM, 2.86 μM, 3.01 μM, 0.21 μM, 6.58 μM, 1.67 μM, 61.1 μM, and 61.7 μM, respectively. Chalepensin potently and selectively kills third-stage infective larvae of Strongyloides venezuelensis ^[1] .

HY-101284

DMU2105	Cytochrome P450	Cancer
DMU2105 is a potent and specific *CYP1B1* inhibitor, with IC₅₀s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.

HY-W015697

3-Methylquinoline	Cytochrome P450	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC₅₀ of 13 μM. 3-Methylquinoline can reduce the metabolic clearance of CYP1A2 substrate drugs. 3-Methylquinoline can inhibit the activation of carcinogenic precursors ^[1].

HY-W275481

γ-Dodecanolactone	Cytochrome P450	Others
γ-Dodecanolactone is a γ-lactone compound. γ-Dodecanolactone exhibits inhibitory activity against *CYP1A2* with an IC₅₀ value of 58 µM and a pIC₅₀ value of 4.24. γ-Dodecanolactone can be used in the research of diseases related to the CYP1A2 enzyme ^[1].

HY-121213

Erysolin	Cytochrome P450	Cancer
Erysolin is a *CYP1A* inhibitor with antigenic toxicity. Erysolin reduces benzo(a)pyrene-induced genotoxicity ^[1].

HY-N1882

4,5-Dimethoxycanthin-6-one	Cytochrome P450	Metabolic Disease
4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of *CYP1A2*-mediated phenacetin O-deethylation with an IC₅₀ value of 1.7μM and a K_i value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae) ^[1] .

HY-W777979

Frutinone A	Cytochrome P450 Bacterial	Infection
Frutinone A is a *CYP1A2* inhibitor, possesses a chromonocoumarin structural scaffold. Frutinone A shows various biological activities, including antibacterial and antioxidant ^[1].

HY-W472509

11-HETE 11-Hydroxy-5,8,12,14-eicosatetraenoic acid	Cytochrome P450	Cardiovascular Disease
11-HETE (11-Hydroxy-5,8,12,14-eicosatetraenoic acid) is the activator for cytochrome P450. 11-HETE upregulates the mRNA expressions of CYP1B1, CYP1A1, CYP4A11, CYP4F11, and CYP4F2, induces cell hypertrophy in RL-14 cell, and exhibits potential to be used in cardiovascular diseases ^[1].

HY-N0125R

Diosmetin (Standard) Maximum Cited Publications 20 Publications Verification	Reference Standards Cytochrome P450	Cancer
Diosmetin (Standard) is the analytical standard of Diosmetin. This product is intended for research and analytical applications. Diosmetin is a natural flavonoid which inhibits human *CYP1A* enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-N3090

Peucedanol	Cytochrome P450	Metabolic Disease
Peucedanol is a non-competitive inhibitor of *CYP3A4* with a K_i value of 4.07 μM and a competitive inhibitor of *CYP1A2* and *CYP2D6* with K_i values of 3.39 μM and 6.77 μM, respectively ^[1].

HY-N10344

Glucoarabin	Cytochrome P450 Quinone Reductase	Cancer
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity ^[1].

HY-175836

CYP1B1-IN-12	Cytochrome P450 Apoptosis	Cancer
CYP1B1-IN-12 is a selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 6.05 nM. CYP1B1-IN-12 demonstrates remarkable selectivity, exceeding 1600-fold and 16,000-fold over CYP1A1 and CYP1A2, respectively. CYP1B1-IN-12 can enhance Paclitaxel (HY-B0015)-mediated apoptosis and restore Paclitaxel sensitivity in A549/Taxol-resistant cells. CYP1B1-IN-12 can inhibit the epithelial-mesenchymal transition process and reduce cells migration and invasion. CYP1B1-IN-12 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC) ^[1].

HY-152196

CYP1B1-IN-5	Cytochrome P450	Cancer
CYP1B1-IN-5 (Compound 6q) is a potent and selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 4.7 nM ^[1].

HY-118216

Bitertanol Biloxazol	Fungal Cytochrome P450	Infection
Bitertanol (Biloxazol) is a potent antifungal agent. Bitertanol also is an *CYP1A1, CYP2B, and CYP3A* inducer in vivo and an *CYP1A* inhibitor in vitro ^[1] .

HY-N0922

Methysticin DL-Methysticin; (±)-Methystici	Cytochrome P450	Neurological Disease
Methysticin is a major kavalactone in kava extract to induce *CYP1A1*.

HY-RS03441

CYP1A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CYP1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYP1A1 Human Pre-designed siRNA Set A CYP1A1 Human Pre-designed siRNA Set A

HY-D0144

Resorufin methyl ether Methoxyresorufin	Cytochrome P450	Others
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate ^[1]. Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents ^[1] .

HY-N6264

26-Deoxyactein	Aryl Hydrocarbon Receptor ERK	Metabolic Disease
26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels ^[1].

HY-N0382R

Galangin (Standard) Norizalpinin (Standard); 3,5,7-Trihydroxyflavone (Standard)	Reference Standards Cytochrome P450 Autophagy	Cancer
Galangin (Standard) is the analytical standard of Galangin. This product is intended for research and analytical applications. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of *CYP1A1* activity.

HY-126308

(E/Z)-DMU2139	Cytochrome P450	Cancer
(E/Z)-DMU2139 (Compound 180) is the E/Z isomer of DMU2139 (HY-101285). (E/Z)-DMU2139 is a potent and specific *CYP1B1* inhibitor (IC₅₀: 4 nM) ^[1].

HY-B0822S1

Fipronil-13C6	GABA Receptor Cytochrome P450	Inflammation/Immunology
Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-148595

CYP1A1-IN-2	Cytochrome P450	Cancer
CYP1A1-IN-2 (Compound 14) is a competitive inhibitor of *CYP1A1* (K_i: 1.4 μM). CYP1A1-IN-2 exhibits potent antimitotic activity and arrests cell in the G2/M phase. CYP1A1-IN-2 disrupts the microtubule and the cytoskeleton in CYP1A1-expressing breast cancer cells ^[1].

HY-152079

CYP1B1-IN-3	Cytochrome P450	Cancer
CYP1B1-IN-3 is a potent and selective *CYP1B1* inhibitor with IC₅₀ values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways ^[1].

HY-174425

CYP1B1-IN-9	Cytochrome P450	Cancer
CYP1B1-IN-9 is a highly selective and competitive *CYP1B1* Inhibitor with IC₅₀ values of 1.48 nM, > 100 μM, and > 80 μM for CYP1B1, CYP1A1, and CYP1A2, respectively. CYP1B1-IN-9 significantly inhibits the migration and invasion of A549/T cells. CYP1B1-IN-9 has the ability to resensitize Paclitaxel (HY-B0015)-resistant cells, and good metabolic stability and safety, and shows favorable pharmacokinetic parameters. CYP1B1-IN-9 can be used for the study of tumor-drug resistance ^[1].

HY-174333

CYP1A1-IN-1	Bacterial Cytochrome P450	Infection Cardiovascular Disease
CYP1A1-IN-1 (Compound 47) is a small-molecule cytochrome P4501A1 (CYP1A1) inhibitor. CYP1A1-IN-1 reduces the bacterial loads of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii by enhancing macrophage phagocytosis. CYP1A1-IN-1 is promising for research of sepsis caused by multidrug-resistant (MDR) bacteria ^[1].

Cat. No.	Product Name	Type

HY-D0145

7-Ethoxyresorufin 1 Publications Verification Resorufin ethyl ether	Fluorescent Dye
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially *CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase* ^[1] .

HY-D0932

Sudan IV

Solvent Red 24; C.I. 26105

Fluorescent Dye

Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections ^[1] .

HY-D0932R

Sudan IV (Standard)

Solvent Red 24 (Standard); C.I. 26105 (Standard)

Fluorescent Dye

Sudan IV (Standard) (Solvent Red 24 (Standard)) is the analytical standard of Sudan IV (HY-D0932). This product is intended for research and analytical applications. Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.

HY-D0144

Resorufin methyl ether Methoxyresorufin	Fluorescent Dye
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate ^[1]. Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents ^[1] .

HY-162051

CYP1B1-IN-6	Fluorescent Dye
CYP1B1-IN-6 (compound 19) is a fluorescence molecular probes which inhibits *CYP1B1* activity. CYP1B1-IN-6 can identify tumor sites in fluorescence imaging and photoacoustic imaging modes ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0125

Diosmetin Maximum Cited Publications 20 Publications Verification	Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Flavones Citrus limon (L.) Burm. F. Rutaceae Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Cytochrome P450
Diosmetin is a natural flavonoid which inhibits human *CYP1A* enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-N0382

Galangin 15+ Cited Publications Norizalpinin; 3,5,7-Trihydroxyflavone	Flavonols Flavonoids Microorganisms Classification of Application Fields Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Source Classification Zingiberaceae Cancer	Cytochrome P450 Autophagy
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of *CYP1A1* activity.

HY-N0043

Ginsenoside Rd 1 Publications Verification Gypenoside VIII	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca ²⁺ influx. Ginsenoside Rd inhibits *CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀*s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-N2194

Bergamottin 5+ Cited Publications 5-Geranoxypsoralen; Bergamotine; Bergaptin	Classification of Application Fields Citrus limon (L.) Burm. F. Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Cytochrome P450
Bergamottin is a potent and competitive *CYP1A1* inhibitor with a K_i of 10.703 nM.

HY-B1234

Octinoxate Octyl methoxycinnamate	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Cosmetic Research Plants Disease Research Fields Source Classification	Environmental Pollutants Estrogen Receptor/ERR Androgen Receptor Cytochrome P450 Thyroid Hormone Receptor
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits *CYP1A1* and *CYP1B1* to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo ^[1] .

HY-N0482

Phillyrin 5+ Cited Publications	Infection Oleaceae Classification of Application Fields Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields Source Classification	Cytochrome P450 Influenza Virus Bacterial
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat *CYP1A2* and *CYP2D1* activities, without affecting CYP2C11 and CYP3A1/2 activities ^[1]. Phillyrin has anti-influenza A virus activities .

HY-W017113

2-Mercaptobenzothiazole 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) ^[1], inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 ^[1]. 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC₅₀ value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .

HY-W011956

6-Hydroxymelatonin	Structural Classification Natural Products Monophenols Phenols Endogenous metabolite Source Classification	Drug Metabolite Endogenous Metabolite
6-Hydroxymelatonin is the main metabolite of melatonin (HY-B0075) after being metabolized by CYP1A2 and can cross the blood-brain barrier. 6-Hydroxymelatonin has strong free radical scavenging ability and antioxidant activity, and can alleviate oxidative damage caused by various neurotoxins. 6-Hydroxymelatonin can cause oxidative DNA damage in the presence of copper ions through a "non-quinone" type redox cycling mechanism ^[1] .

HY-N0563

Alizarin 1 Publications Verification	Quinones Classification of Application Fields Anthraquinones Rubiaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Rubia cordifolia L. Source Classification	AMPK VEGFR PI3K Akt NF-κB Cytochrome P450
Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances *CYP1A1* enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings ^[1] .

HY-Y0110

2-Naphthol 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-N6677

β-Apo-8'-carotenal Apocarotenal	Other Terpenoids Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Cytochrome P450 DNA/RNA Synthesis
β-Apo-8'-carotenal (Apocarotenal), an orally active provitamin A carotenoid. β-Apo-8'-carotenal can induce the expression of *CYP1A* through the Ah receptor-dependent pathway. β-Apo-8'-carotenal can induce cancer cells DNA strand breaks and lipid peroxidation. β-Apo-8'-carotenal can be used for the researches of cancer and metabolic disease ^[1] .

HY-N2374

Eupatorin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Source Classification Cancer	Apoptosis NF-κB MMP Adrenergic Receptor
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. Eupatorin downregulates the expression levels of NF-κB, MMP9, *IL-1β* and TNF-α. Eupatorin induces apoptosis, G2/M phase cell cycle arrest, and reactive oxygen species (ROS) production. Eupatorin modulates the activities of muscarinic receptors and β-adrenergic receptors; inhibits sarcoplasmic reticulum calcium release and calcium channels; and activates the NO/sGC/cGMP pathway, indomethacin-sensitive pathway, and potassium channel pathway. Eupatorin exerts cytotoxic effects on cancer cell lines, and is metabolized by *CYP1A1* and CYP1 family enzymes to form metabolites with antiproliferative activity. Eupatorin can be used in research related to breast cancer, hypertension, and leukemia ^[1] .

HY-30152

Xanthotoxol 2 Publications Verification 8-Hydroxypsoralen	Monophenols other families Coumarins Phenols Phenylpropanoids Plants Endogenous metabolite Source Classification	5-HT Receptor Reactive Oxygen Species (ROS) Endogenous Metabolite
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.

HY-N5132

(-)-Fenchone	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Other Diseases Umbelliferae Plants Vernonia Schreb. Disease Research Fields Source Classification	Cytochrome P450
(-)-Fenchone is a bicyclic monoterpene and serves as a substrate for human liver microsomal cytochrome P450 enzymes *CYP2A6* and *CYP2B6. (-)-Fenchone is not metabolized by human CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4 enzymes. (-)-Fenchone undergoes hydroxylation to produce 6-exo-hydroxyfenchone, 6-endo-hydroxyfenchone, and 10-hydroxyfenchone. During the metabolism of (-)-Fenchone, CYP2A6 may play a more important role than CYP*2B6 ^[1].

HY-N1050

Zederone	Terpenoids Sesquiterpenes Plants Curcuma elata Roxb. Source Classification Zingiberaceae	mTOR Ribosomal S6 Kinase (RSK) Bacterial
Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC₅₀s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD₅₀ value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis ^[1] .

HY-N2625A

Harmalol hydrochloride	Alkaloids Monophenols Classification of Application Fields Zygophyllaceae Peganum harmala Linn. Other Diseases Phenols Pyridine Alkaloids Plants Disease Research Fields Source Classification	Cytochrome P450
Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties ^[1].

HY-W010195

2,6-Dimethylquinoline	Alkaloids Chrysanthemum × morifolium (Ramat.) Hemsl. Classification of Application Fields Other Diseases Quinoline Alkaloids Umbelliferae Plants Disease Research Fields Source Classification	Cytochrome P450
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a *CYP1A2* inhibitor with an IC₅₀ of 3.3 µM. 2,6-Dimethylquinoline also inhibits *CYP2B6* activity with an IC₅₀ of 480 µM ^[1] .

HY-N2382

Polyphyllin H 1 Publications Verification	Structural Classification other families Plants Steroids Source Classification	Cytochrome P450 P-glycoprotein
Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of *CYP1A2* (IC₅₀ = 6.44 μM, competitive), *CYP2D6* (IC₅₀ = 13.88 μM, competitive) and *CYP3A4* (IC₅₀ = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of *ABCB1* and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel ^[1] .

HY-W045990

2,7-Dimethylnaphthalene	Structural Classification Natural Products Rosaceae Pyracantha fortuneana (Maxim.) H.L.Li Plants Source Classification	Cytochrome P450
2,7-Dimethylnaphthalene is a selective cytochrome P450 1A2 (CYP1A2) enzyme inhibitor with an IC₅₀ of 65 μM. 2,7-Dimethylnaphthalene can be used for the research of metabolic disease ^[1].

HY-N8382

Chalepensin	Structural Classification Natural Products Haloxylon ammodendron (C. A. Mey.) Bunge Amaranthaceae Plants Source Classification	Cytochrome P450 Parasite Insecticide
Chalepensin is a nematicide and *CYP* inhibitor. Chalepensin inhibits *CYP2A6, CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4* to varying degrees, with IC₅₀ values of 82.3 μM, 2.86 μM, 3.01 μM, 0.21 μM, 6.58 μM, 1.67 μM, 61.1 μM, and 61.7 μM, respectively. Chalepensin potently and selectively kills third-stage infective larvae of Strongyloides venezuelensis ^[1] .

HY-N1882

4,5-Dimethoxycanthin-6-one	Alkaloids Simaroubaceae Classification of Application Fields Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields Indole Alkaloids Source Classification	Cytochrome P450
4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of *CYP1A2*-mediated phenacetin O-deethylation with an IC₅₀ value of 1.7μM and a K_i value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae) ^[1] .

HY-W777979

Frutinone A	Hydroleaceae Polygala fruticosa P.J.Bergius Polygalaceae Coumarins Phenylpropanoids Plants Source Classification	Cytochrome P450 Bacterial
Frutinone A is a *CYP1A2* inhibitor, possesses a chromonocoumarin structural scaffold. Frutinone A shows various biological activities, including antibacterial and antioxidant ^[1].

HY-N0125R

Diosmetin (Standard) Maximum Cited Publications 20 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Citrus limon (L.) Burm. F. Rutaceae Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Reference Standards Cytochrome P450
Diosmetin (Standard) is the analytical standard of Diosmetin. This product is intended for research and analytical applications. Diosmetin is a natural flavonoid which inhibits human *CYP1A* enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-N3090

Peucedanol	Carpesium cernuum L. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Cytochrome P450
Peucedanol is a non-competitive inhibitor of *CYP3A4* with a K_i value of 4.07 μM and a competitive inhibitor of *CYP1A2* and *CYP2D6* with K_i values of 3.39 μM and 6.77 μM, respectively ^[1].

HY-N10344

Glucoarabin	Natural Products Classification of Application Fields Camelina sativa (L.) Crantz Glucosinolates Plants Brassicaceae Disease Research Fields Source Classification Cancer	Cytochrome P450 Quinone Reductase
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity ^[1].

HY-W087919

5-Methyl-2-furanmethanol	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Dianthus rupicola Biv. Plants Disease Research Fields Source Classification	Cytochrome P450
5-Methyl-2-furanmethanol is a natural product that can be isolated from the essential oil of D. rupicola Biv.. 5-Methyl-2-furanmethanol also acts as a oxidative product of 2,5 dimethylfuran (DMF) by cytochrome P450 (CYP) .

HY-129247

Versicolorin A	Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Other Diseases Disease Research Fields Source Classification	MDM-2/p53 Aryl Hydrocarbon Receptor Cytochrome P450
Versicolorin A is a biosynthetic precursor of Aflatoxin B1 (HY-N6615). Versicolorin A induces phosphorylation of p53. Versicolorin A activates the aryl hydrocarbon receptor AhR and significantly induces the expression of *CYP1A1. Versicolorin A exerts genotoxic and cytotoxic effects. Versicolorin A enhances the genotoxicity of aflatoxin B1 in cells by promoting CYP450*-mediated bioactivation of aflatoxin B1. Versicolorin A can be used in research related to colorectal cancer and hepatocellular carcinoma ^[1] .

HY-N0922

Methysticin DL-Methysticin; (±)-Methystici	Natural Products other families Plants Source Classification	Cytochrome P450
Methysticin is a major kavalactone in kava extract to induce *CYP1A1*.

HY-N6264

26-Deoxyactein	Triterpenes Classification of Application Fields Terpenoids Ranunculaceae Metabolic Disease Cimicifuga foetida Linn. Plants Cimicifuga racemosa (L.) Nutt. Disease Research Fields Source Classification	Aryl Hydrocarbon Receptor ERK
26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels ^[1].

HY-N0382R

Galangin (Standard) Norizalpinin (Standard); 3,5,7-Trihydroxyflavone (Standard)	Flavonoids Classification of Application Fields Phenols Alpinia officinarum Hance Plants Disease Research Fields Source Classification Zingiberaceae Cancer	Reference Standards Cytochrome P450 Autophagy
Galangin (Standard) is the analytical standard of Galangin. This product is intended for research and analytical applications. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of *CYP1A1* activity.

HY-Y0110R

2-Naphthol (Standard)	Structural Classification Monophenols Microorganisms Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2-Naphthol (Standard) is the analytical standard of 2-Naphthol. This product is intended for research and analytical applications. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-N4205R

Tetrahydropiperine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Piperaceae Plants Piper nigrum Linn. Source Classification	Reference Standards Cytochrome P450
Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum ^[1]. Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .

HY-N2194R

Bergamottin (Standard) 5-Geranoxypsoralen (Standard); Bergamotine (Standard); Bergaptin (Standard)	Structural Classification Citrus limon (L.) Burm. F. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Reference Standards Cytochrome P450
Bergamottin (Standard) is the analytical standard of Bergamottin. This product is intended for research and analytical applications. Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM.

HY-W010195R

2,6-Dimethylquinoline (Standard)	Alkaloids Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Quinoline Alkaloids Umbelliferae Plants Source Classification	Reference Standards Cytochrome P450
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 µM ^[1] .

HY-N2689

(R)-6',7'-Dihydroxybergamottin (R)-6′,7′-DHB	Structural Classification Citrus × aurantium Linnaeus Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Cytochrome P450
(R)-6',7'-Dihydroxybergamottin ((R)-6′,7′-DHB) is a competitive inhibitor of human and rat *CYP1A1* activity with K_is of 55 μM and 1.72 μM, respectively. (R)-6',7'-Dihydroxybergamottin has the potential for cancer research ^[1].

HY-N6264R

26-Deoxyactein (Standard)	Triterpenes Structural Classification Terpenoids Ranunculaceae Cimicifuga foetida Linn. Plants Cimicifuga racemosa (L.) Nutt. Source Classification	Reference Standards Aryl Hydrocarbon Receptor ERK
26-Deoxyactein (Standard) is the analytical standard of 26-Deoxyactein. This product is intended for research and analytical applications. 26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels ^[1].

HY-N2625AR

Harmalol hydrochloride (Standard)	Alkaloids Structural Classification Monophenols Zygophyllaceae Peganum harmala Linn. Phenols Pyridine Alkaloids Plants Source Classification	Reference Standards Cytochrome P450
Harmalol (hydrochloride) (Standard) is the analytical standard of Harmalol (hydrochloride). This product is intended for research and analytical applications. Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties ^[1].

HY-N0482R

Phillyrin (Standard)	Structural Classification Oleaceae Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Source Classification	Reference Standards Cytochrome P450 Influenza Virus Bacterial
Phillyrin (Standard) is the analytical standard of Phillyrin. This product is intended for research and analytical applications. Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities ^[1]. Phillyrin has anti-influenza A virus activities .

HY-30152R

Xanthotoxol (Standard) 8-Hydroxypsoralen (Standard)	Structural Classification Monophenols other families Coumarins Phenols Phenylpropanoids Plants Endogenous metabolite Source Classification	Reference Standards 5-HT Receptor Reactive Oxygen Species (ROS) Endogenous Metabolite
Xanthotoxol (Standard) is the analytical standard of Xanthotoxol. This product is intended for research and analytical applications. Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC₅₀s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation ^[1] .

HY-W011956R

6-Hydroxymelatonin (Standard)	Structural Classification Natural Products Monophenols Phenols Endogenous metabolite Source Classification	Drug Metabolite Reference Standards Endogenous Metabolite
6-Hydroxymelatonin (Standard) is the analytical standard of 6-Hydroxymelatonin. This product is intended for research and analytical applications. 6-Hydroxymelatonin is the main metabolite of melatonin (HY-B0075) after being metabolized by CYP1A2 and can cross the blood-brain barrier. 6-Hydroxymelatonin has strong free radical scavenging ability and antioxidant activity, and can alleviate oxidative damage caused by various neurotoxins. 6-Hydroxymelatonin can cause oxidative DNA damage in the presence of copper ions through a "non-quinone" type redox cycling mechanism.

HY-N0043R

Ginsenoside Rd (Standard) Gypenoside VIII (Standard)	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	Reference Standards NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite
Ginsenoside Rd (Standard) is the analytical standard of Ginsenoside Rd. This product is intended for research and analytical applications. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-W142473

1,2-Dimethylnaphthalene	Structural Classification Natural Products Leguminosae Tamarindus indica L. Plants Source Classification	Cytochrome P450
1,2-Dimethylnaphthalene is a CYP1A2 inhibitor with an IC₅₀ of 5.5 μM and a pIC₅₀ of 5.26 ^[1].

HY-W087919R

5-Methyl-2-furanmethanol (Standard)	Natural Products other families Dianthus rupicola Biv. Plants Source Classification	Reference Standards Others
5-Methyl-2-furanmethanol (Standard) is the analytical standard of 5-Methyl-2-furanmethanol. This product is intended for research and analytical applications. 5-Methyl-2-furanmethanol is a natural product that can be isolated from the essential oil of D. rupicola Biv.. 5-Methyl-2-furanmethanol also acts as a oxidative product of 2,5 dimethylfuran (DMF) by cytochrome P450 (CYP)[1][2].

Cat. No.	Product Name	Chemical Structure

HY-Y0110S1

2-Naphthol-d7
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol ^[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-B0476S

Phenacetin-d5
Phenacetin-d₅ is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats ^[1] .

HY-D0145S

7-Ethoxyresorufin-d5
7-Ethoxyresorufin-d₅ is deuterium labeled 7-Ethoxyresorufin. 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase ^[1] .

HY-B0476S1

Phenacetin-13C
Phenacetin- ¹³C is the ¹³C labeled Phenacetin ^[1]. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-B0822S1

Fipronil-13C6

Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-B0973S

Dibenzothiophene-d8

Dibenzothiophene-d₈ is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms ^[1] .

HY-Y0110S

2-Naphthol-d8
2-Naphthol-d₈ is the deuterium labeled 2-Naphthol ^[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-B0352AS

(S)-Mirtazapine-d3
(S)-Mirtazapine-d₃ is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].

HY-N0125S

Diosmetin-d3
Diosmetin-d₃ is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.

HY-N0382S

Galangin-13C3
Galangin- ¹³C₃ is the ¹³C-labeled Galangin. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.

HY-133091S

7-Ethoxycoumarin-d5
7-Ethoxycoumarin-d₅ is deuterium labeled 7-Ethoxycoumarin. 7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs .

HY-B1234S

Octinoxate-13C,d3

Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo ^[1] .

HY-W713284

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate

2-Ethylhexyl (E)-3-(4-(methoxy-d₃)phenyl)acrylate is the deuterium labeled Octinoxate (HY-B1234). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo ^[1] .

HY-D0932S

Sudan IV-d6

Sudan IV-d₆ (Solvent Red 24-d₆) is the deuterium labeled Sudan IV(HY-D0932). Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections ^[1] .

HY-G0007S

Omeprazole sulfone-d3

Omeprazole sulfone-d₃ is the deuterium labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair ^[1] .

HY-G0007S1

Omeprazole sulfone-13C,d3

Omeprazole sulfone- ¹³C,d₃ is the deuterium and ¹³C labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair ^[1] .

HY-W707708

N-(4-Ethoxyphenyl)acetamide-2,2,2-d3
N-(4-Ethoxyphenyl)acetamide-2,2,2-d₃ is the deuterium labeled Phenacetin (HY-B0476). Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats ^[1] .

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (1) Mouse (1)
Application:	IHC-P (3) ICC/IF (1) WB (2) FC (2) ELISA (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87408

	CYP1A1 Antibody (YA7096)	IHC-P, ELISA	Human
	CYP1A1 Antibody (YA7096) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CYP1A1.

HY-P87408A

	CYP1A1 Antibody (YA7096)(PBS only)	IHC-P, ELISA	Human
	CYP1A1 Antibody (YA7096) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CYP1A1.

HY-P82091

	Cytochrome P450 1B1 Antibody (YA1836) CYP1B1; Cytochrome P450 1B1; CYPIB1	WB, IHC-P, FC	Human, Mouse, Rat
	Cytochrome P450 1B1 Antibody (YA1836) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 1B1.

HY-P81245

	Cytochrome P450 1A2 Antibody (YA3505) Cytochrome P450 1A2; cytochrome P450, family 1, subfamily a, polypeptide 2; Cytochrome P450 family 1 polypeptide 2; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; CYP1a2; CYPD45; P-450d; RATCYPD45; CP12; CP 12; P3-450; Aryl hydrocarbon hydroxylase; Dioxin inducable P3 45; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 4; P450 form 4; P450 P3; P450(PA); Xenobiotic monooxygenase; P450 1A2.	WB, ICC/IF, FC	Human
	Cytochrome P450 1A2 Antibody (YA3505) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 1A2.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-174333

CYP1A1-IN-1		Alkynes
CYP1A1-IN-1 (Compound 47) is a small-molecule cytochrome P4501A1 (CYP1A1) inhibitor. CYP1A1-IN-1 reduces the bacterial loads of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii by enhancing macrophage phagocytosis. CYP1A1-IN-1 is promising for research of sepsis caused by multidrug-resistant (MDR) bacteria ^[1].

HY-119578

Imiprothrin		Alkynes
Imiprothrin is an inducer that induces *CYP1A2* and metallothionein 1a, with significant genotoxicity and cytotoxicity. In rat hepatocytes, Imiprothrin initiates detoxification responses by triggering the overexpression of these two genes. Imiprothrin induces chromosomal aberrations and micronucleus formation in rat bone marrow cells, and causes DNA damage in hepatocytes. Imiprothrin triggers oxidative stress in rats, leading to lipid peroxidation, excessive reactive oxygen species production and redox imbalance, which in turn impairs liver and kidney functions and causes tissue damage. Imiprothrin inhibits weight gain in mice, and even causes high mortality in female mice at high doses. However, it shows no carcinogenicity in rat experiments; among relevant indicators, aspartate aminotransferase and total protein are identified as sensitive toxicity biomarkers ^[1] .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

CYP1

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Natural
Products