1 Result for "

D 223

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "D 223" in MCE Product Catalog:

Cat. No.: HY-W1126235
CAS No.: 2253733-45-6
Synonyms: D223
Research Areas:  

Metabolic Disease

DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα, with a Kd of 0.76 μM for p110α. DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude (KD = 0.017 μM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin. DS02312223 can be used in diabetes research .
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