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Dunn

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Calcium Channel (2) Cytochrome P450 (1) Drug Derivative (1) HCV Protease (1) Interleukin Related (1) Microtubule/Tubulin (2) NF-κB (1) Pregnane X Receptor (PXR) (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Inflammation/Immunology (1)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13442A

Eribulin mesylate 5+ Cited Publications B1939 mesylate; E7389 mesylate; ER-086526 mesylate	Microtubule/Tubulin Apoptosis	Cancer
Eribulin mesylate is an inhibitor for microtubule. Eribulin mesylate inhibits the proliferation of cancer cell LM8 and Dunn, inhibits the cell migration of LM8, arrests the cell cycle at G2/M phase, and induces apoptosis in LM8. Eribulin mesylate exhibits antitumor efficacy in mouse model .

HY-N6066

Praeruptorin E	Calcium Channel NF-κB Pregnane X Receptor (PXR) Cytochrome P450 Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Praeruptorin E is an orally active pyranocoumarin compound. Praeruptorin E can be isolated from the dried roots of Peucedanum praeruptorum Dunn. Praeruptorin E reduces the expression of NF-κB. Praeruptorin E upregulates the expression of PXR and CYP3A4. Praeruptorin E inhibits Th2 cytokines, TNF-α, IL6, MPO, and blocks the Ca ²⁺ slow channel. Praeruptorin E promotes pulmonary tissue repair and relaxes porcine coronary artery strips. Praeruptorin E protects mice from lipopolysaccharide- and hydrochloric acid-induced acute lung injury. Praeruptorin E can be used in studies related to asthma and acute lung injury .

HY-13442C

Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) B1939 mesylate (purity>99%, single impurity ≤ 0.15%); E7389 mesylate (purity>99%, single impurity ≤ 0.15%); ER-086526 mesylate (purity>99%, single impurity ≤ 0.15%)	Microtubule/Tubulin Apoptosis	Cancer
Eribulin (B1939; E7389; ER-086526) mesylate (purity>99%, single impurity ≤ 0.15%) is an inhibitor for microtubule. Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) inhibits the proliferation of cancer cell LM8 and Dunn, inhibits the cell migration of LM8, arrests the cell cycle at G2/M phase, and induces apoptosis in LM8. Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) exhibits antitumor efficacy in mouse model .

HY-N7542

Praeroside II	HCV Protease	Others
Praeroside II is an angular-type pyranocoumarm glycoside. Praeroside II can be isolated from the n-butanol-extracts of P. praeruptorum Dunn. Praeroside II can be used for pharmacological study .

HY-N8637

Qianhucoumarin E	Others	Others
Qianhucoumarin E is an angular-type pyranocoumarin from the roots of Peucedanum praeruptorum Dunn .

HY-N8632

Qianhucoumarin A	Others	Others
Qianhucoumarin A is a natural coumarin compound found in the roots of Peucedanum praeruptorum Dunn .

HY-N7759

Peucedanol 7-O-glucoside	Others	Others
Peucedanol 7-O-glucoside is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

HY-N0081A

(-)-Praeruptorin A	Calcium Channel	Cardiovascular Disease
(-)-Praeruptorin A is a nature product that could be isolated from the roots of Peucedanum praeruptorum Dunn. (-)-Praeruptorin A relaxes ileum and tracheal smooth muscles by activating NO/cGMP signaling pathway. (-)-Praeruptorin A has dramatically therapeutic effects on hypertension mainly through acting as a Ca ²⁺-influx blocker .

HY-N17376

Praeroside VI	Others	Others
Praeroside VI (Compound 2) is a coumarin glycoside found in the roots of Peucedanum praeruptorum Dunn .

HY-N17508

Qianhucoumarin J	Drug Derivative	Others
Qianhucoumarin J (Compound 2) is a khellactone-derived coumarin (3'(S)-angeloyloxy-4'(S)-propionyloxy-3',4'-dihydroseselin) that can be found in the roots of Peucedanum praeruptorum Dunn .

HY-N17832

Actinoside F Kaempferol 3-O-4'''-acetylrhamninoside	Others	Others
Actinoside F (Kaempferol 3-O-4'''-acetylrhamninoside) is a flavonoid glycoside that exists in the aerial parts of Patrinia villosa (THUNB.) JUSS. and the leaves of Actinidia valvata Dunn .

HY-N11575

Peucedanoside A	Others	Others
Peucedanoside A is a glycoside that can be isolated from the roots of Peucedanum praeruptorum Dunn .

HY-N1233

Songoramine Zongoramine	Others	Others
Songoramine (Zongoramine) is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

HY-N7816

trans-Methylkhellactone	Others	Others
trans-Methylkhellactone is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

HY-N7839

cis-Methylkhellactone	Others	Others
cis-Methylkhellactone is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

HY-N7732

Peucedanol 3'-O-glucoside	Others	Others
Peucedanol 3'-O-glucoside is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

HY-N4050

Heraclenol acetonide O-Isopropylideneheraclenol	Others	Others
Heraclenol acetonide (O-?Isopropylideneheracl?enol) is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

HY-N8851

trans-3'-O-Benzoyl-4'-O-methylkhellactone	Others	Others
trans-3'-O-Benzoyl-4'-O-methylkhellactone is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

HY-N17559

Praeroside V	Others	Others
Praeroside V is an angular-type pyranocoumarm glycoside. Praeroside V can be isolated from the n-butanol extracts of Bai-Hua Qian-Hu, the root of Peucedanum praeruptorum Dunn .

HY-N17833

Actinoside E Kaempferol 3-O-2,4'''-acetylrhamninoside	Reactive Oxygen Species (ROS)	Cardiovascular Disease
Actinoside E (Kaempferol 3-O-2,4'''-acetylrhamninoside) is a flavonoid triglycoside with antioxidant activity. Actinoside E scavenges DPPH, superoxide anion and hydroxyl radicals, and inhibits lipid peroxidation in mouse liver homogenate. Actinoside E can be used in studies related to myocardial ischemia .

Praeruptorin E	Cardiovascular Disease Structural Classification Classification of Application Fields Coumarins Salvia hypargeia Fisch. & C.A.Mey. Phenylpropanoids Umbelliferae Plants Disease Research Fields Source Classification	Calcium Channel NF-κB Pregnane X Receptor (PXR) Cytochrome P450 Interleukin Related
Praeruptorin E is an orally active pyranocoumarin compound. Praeruptorin E can be isolated from the dried roots of Peucedanum praeruptorum Dunn. Praeruptorin E reduces the expression of NF-κB. Praeruptorin E upregulates the expression of PXR and CYP3A4. Praeruptorin E inhibits Th2 cytokines, TNF-α, IL6, MPO, and blocks the Ca ²⁺ slow channel. Praeruptorin E promotes pulmonary tissue repair and relaxes porcine coronary artery strips. Praeruptorin E protects mice from lipopolysaccharide- and hydrochloric acid-induced acute lung injury. Praeruptorin E can be used in studies related to asthma and acute lung injury .

Praeroside II	Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants	HCV Protease
Praeroside II is an angular-type pyranocoumarm glycoside. Praeroside II can be isolated from the n-butanol-extracts of P. praeruptorum Dunn. Praeroside II can be used for pharmacological study .

Qianhucoumarin E	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
Qianhucoumarin E is an angular-type pyranocoumarin from the roots of Peucedanum praeruptorum Dunn .

Qianhucoumarin A	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
Qianhucoumarin A is a natural coumarin compound found in the roots of Peucedanum praeruptorum Dunn .

Peucedanol 7-O-glucoside	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Others
Peucedanol 7-O-glucoside is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

(-)-Praeruptorin A	Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Calcium Channel
(-)-Praeruptorin A is a nature product that could be isolated from the roots of Peucedanum praeruptorum Dunn. (-)-Praeruptorin A relaxes ileum and tracheal smooth muscles by activating NO/cGMP signaling pathway. (-)-Praeruptorin A has dramatically therapeutic effects on hypertension mainly through acting as a Ca ²⁺-influx blocker .

Praeroside VI	Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Others
Praeroside VI (Compound 2) is a coumarin glycoside found in the roots of Peucedanum praeruptorum Dunn .

Qianhucoumarin J	Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Drug Derivative
Qianhucoumarin J (Compound 2) is a khellactone-derived coumarin (3'(S)-angeloyloxy-4'(S)-propionyloxy-3',4'-dihydroseselin) that can be found in the roots of Peucedanum praeruptorum Dunn .

Actinoside F Kaempferol 3-O-4'''-acetylrhamninoside	Structural Classification Flavonoids Caprifoliaceae Flavonones Patrinia villosa (Thunb.) Juss. Plants Source Classification	Others
Actinoside F (Kaempferol 3-O-4'''-acetylrhamninoside) is a flavonoid glycoside that exists in the aerial parts of Patrinia villosa (THUNB.) JUSS. and the leaves of Actinidia valvata Dunn .

Peucedanoside A	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
Peucedanoside A is a glycoside that can be isolated from the roots of Peucedanum praeruptorum Dunn .

Songoramine Zongoramine	Alkaloids Pyrrole Alkaloids Ranunculaceae Aconitum brachypodum Diels Plants Source Classification	Others
Songoramine (Zongoramine) is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

trans-Methylkhellactone	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Others
trans-Methylkhellactone is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

cis-Methylkhellactone	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Others
cis-Methylkhellactone is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

Peucedanol 3'-O-glucoside	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Others
Peucedanol 3'-O-glucoside is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

Heraclenol acetonide O-Isopropylideneheraclenol	Coumarins Ageratina altissima (L.) R.M.King & H.Rob. Phenylpropanoids Umbelliferae Plants Source Classification	Others
Heraclenol acetonide (O-?Isopropylideneheracl?enol) is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

trans-3'-O-Benzoyl-4'-O-methylkhellactone	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Others
trans-3'-O-Benzoyl-4'-O-methylkhellactone is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .

Praeroside V	Structural Classification Terpenoids Labiatae Tamarindus indica L. Diterpenoids Plants Source Classification	Others
Praeroside V is an angular-type pyranocoumarm glycoside. Praeroside V can be isolated from the n-butanol extracts of Bai-Hua Qian-Hu, the root of Peucedanum praeruptorum Dunn .

Actinoside E Kaempferol 3-O-2,4'''-acetylrhamninoside	Structural Classification Flavonoids Flavonones Plants Actinidiaceae Actinidia valvata Dunn Source Classification	Reactive Oxygen Species (ROS)
Actinoside E (Kaempferol 3-O-2,4'''-acetylrhamninoside) is a flavonoid triglycoside with antioxidant activity. Actinoside E scavenges DPPH, superoxide anion and hydroxyl radicals, and inhibits lipid peroxidation in mouse liver homogenate. Actinoside E can be used in studies related to myocardial ischemia .

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Dunn

Inhibitors & Agonists

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Natural
Products