Erwinia carotovora

By Targets:	ADC Payload (1) Antibiotic (3) Bacterial (8) Biochemical Assay Reagents (1) Flavivirus (2) Fungal (3) Herbicide (1) HIV (2) HSV (2) Influenza Virus (2) Mitochondrial Metabolism (1) Parasite (1) SARS-CoV (2) Ser/Thr Protease (2) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (1) Infection (10) Inflammation/Immunology (3) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114936

Piericidin A 5 Publications Verification AR-054	Bacterial ADC Payload Antibiotic Mitochondrial Metabolism	Infection Neurological Disease Cancer
Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .

HY-W008806

N-(3-Oxohexanoyl)-L-homoserine lactone OHHL; N-(3-Oxohexanoyl)homoserine lactone	Bacterial	Infection Inflammation/Immunology
N-(3-Oxohexanoyl)-L-homoserine lactone (OHHL; N-(3-Oxohexanoyl)homoserine lactone) is a specific agonist of LuxR-type transcription factor CarR with a K_d of 1.8 μM. N-(3-Oxohexanoyl)-L-homoserine lactone activates CarR by inducing protein multimerization, promoting its binding to target DNA sequences in the carR-carA intergenic region, thereby upregulating the transcription of carbapenem biosynthesis genes. N-(3-Oxohexanoyl)-L-homoserine lactone acts as a quorum sensing signal molecule, enabling bacteria to coordinate the production of carbapenem antibiotics in a cell density-dependent manner. N-(3-Oxohexanoyl)-L-homoserine lactone is used to study bacterial quorum sensing mechanisms, especially the secondary metabolism and virulence factor regulatory pathways of Erwinia carotovora and Yersinia enterocolitica .

HY-E70119

Pectate Lyase	Fungal	Infection
Pectate Lyase is an enzyme that exists in microorganisms, plants and animals. Pectate Lyase degrades pectic acid via the β-elimination mechanism. Pectate Lyase induces plant immune responses and participates in virulence. Pectate Lyase is applied in fields such as plant fiber degumming and fruit and vegetable processing .

HY-N12954

(R)-Mucronulatol	Bacterial	Infection
(R)-Mucronulatol is a flavonoid that can be isolated from Astragalus adsurgens. (R)-Mucronulatol shows antibacterial activity against Escherichia coli, Bacillus cereus, Staphylococcus aureus, Erwinia carotovora and Bacillus subtili, with MICs of 15.5, 15.5, 7.8, 7.8, 15.5 μg/mL respectively .

HY-W127393

N-Nonanoyl-L-homoserine lactone	Biochemical Assay Reagents	Others
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

HY-P5642

Retrocyclin-101 RC-101	Bacterial Ser/Thr Protease Influenza Virus HSV SARS-CoV Toll-like Receptor (TLR) Fungal HIV Flavivirus	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression .

HY-N15117

Polymyxin P1	Antibiotic Bacterial	Infection
Polymyxin P1 is a lipopeptide antibiotic belonging to the Polymyxin family, and it is a secondary metabolite produced by the rhizosphere bacterium Paenibacillus polymyxa M-1. Polymyxin P1 binds to bacterial outer membrane lipopolysaccharides, permeabilizes cell membranes, and induces dense protrusions on the cell surface of phytopathogenic Erwinia strains. Polymyxin P1 inhibits the growth of phytopathogenic Erwinia amylovora and E. carotovora. Polymyxin P1 can be used for the research of fire blight and soft rot .

HY-120242

N-(3-Oxobutanoyl)-L-homoserine lactone	Bacterial	Infection
N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) is a carbapenem antibiotic biosynthesis autoregulator in Erwinia carotovora ATCC 39048. N-(3-Oxobutanoyl)-L-homoserine lactone induces expression of rhiI in R. leguminosarum .

HY-N15117A

Polymyxin P1 TFA	Antibiotic Bacterial	Infection
Polymyxin P1 TFA is a lipopeptide antibiotic belonging to the Polymyxin family, and it is a secondary metabolite produced by the rhizosphere bacterium Paenibacillus polymyxa M-1. Polymyxin P1 TFA binds to bacterial outer membrane lipopolysaccharides, permeabilizes cell membranes, and induces dense protrusions on the cell surface of phytopathogenic Erwinia strains. Polymyxin P1 TFA inhibits the growth of phytopathogenic Erwinia amylovora and E. carotovora. Polymyxin P1 TFA can be used for the research of fire blight and soft rot .

HY-W714201

Nitralin	Herbicide Parasite	Infection
Nitralin is a dinitroaniline herbicide. Nitralin exhibits inhibitory activity against Cryptosporidium parvum, with a IC₅₀ of 4.5 µM .

HY-P5642A

Retrocyclin-101 TFA RC-101 TFA	HIV SARS-CoV Influenza Virus Flavivirus HSV Bacterial Fungal Toll-like Receptor (TLR) Ser/Thr Protease	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) TFA is an artificially synthesized, cyclic-structured θ-defensin, a broad-spectrum agent with antimicrobial (covering viruses, bacteria, and fungi) activity and anti-inflammatory activity. Retrocyclin-101 TFA can inhibit the serine protease activity of ZIKV NS2B-NS3, with an IC₅₀ of 7.20 μM. Retrocyclin-101 TFA has significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus, etc. Retrocyclin-101 TFA inhibits the signal transduction mediated by TLR4 and TLR2, reducing the expression of pro-inflammatory cytokines .

Cat. No.	Product Name	Type

HY-W127393

N-Nonanoyl-L-homoserine lactone	Biochemical Assay Reagents
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

N-Nonanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

Cat. No.	Product Name	Target	Research Area

HY-P5642

Retrocyclin-101 RC-101	Bacterial Ser/Thr Protease Influenza Virus HSV SARS-CoV Toll-like Receptor (TLR) Fungal HIV Flavivirus	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression .

HY-N15117

Polymyxin P1	Antibiotic Bacterial	Infection
Polymyxin P1 is a lipopeptide antibiotic belonging to the Polymyxin family, and it is a secondary metabolite produced by the rhizosphere bacterium Paenibacillus polymyxa M-1. Polymyxin P1 binds to bacterial outer membrane lipopolysaccharides, permeabilizes cell membranes, and induces dense protrusions on the cell surface of phytopathogenic Erwinia strains. Polymyxin P1 inhibits the growth of phytopathogenic Erwinia amylovora and E. carotovora. Polymyxin P1 can be used for the research of fire blight and soft rot .

HY-N15117A

Polymyxin P1 TFA	Antibiotic Bacterial	Infection
Polymyxin P1 TFA is a lipopeptide antibiotic belonging to the Polymyxin family, and it is a secondary metabolite produced by the rhizosphere bacterium Paenibacillus polymyxa M-1. Polymyxin P1 TFA binds to bacterial outer membrane lipopolysaccharides, permeabilizes cell membranes, and induces dense protrusions on the cell surface of phytopathogenic Erwinia strains. Polymyxin P1 TFA inhibits the growth of phytopathogenic Erwinia amylovora and E. carotovora. Polymyxin P1 TFA can be used for the research of fire blight and soft rot .

HY-P5642A

Retrocyclin-101 TFA RC-101 TFA	HIV SARS-CoV Influenza Virus Flavivirus HSV Bacterial Fungal Toll-like Receptor (TLR) Ser/Thr Protease	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) TFA is an artificially synthesized, cyclic-structured θ-defensin, a broad-spectrum agent with antimicrobial (covering viruses, bacteria, and fungi) activity and anti-inflammatory activity. Retrocyclin-101 TFA can inhibit the serine protease activity of ZIKV NS2B-NS3, with an IC₅₀ of 7.20 μM. Retrocyclin-101 TFA has significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus, etc. Retrocyclin-101 TFA inhibits the signal transduction mediated by TLR4 and TLR2, reducing the expression of pro-inflammatory cytokines .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-114936

Piericidin A 5 Publications Verification AR-054	Infection Microorganisms Neurological Disease Classification of Application Fields Antibiotics Anti-parasitic Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Bacterial ADC Payload Antibiotic Mitochondrial Metabolism
Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .

HY-N12954

(R)-Mucronulatol	Monophenols Astragalus laxmannii Jacq. Leguminosae Phenols Plants Source Classification	Bacterial
(R)-Mucronulatol is a flavonoid that can be isolated from Astragalus adsurgens. (R)-Mucronulatol shows antibacterial activity against Escherichia coli, Bacillus cereus, Staphylococcus aureus, Erwinia carotovora and Bacillus subtili, with MICs of 15.5, 15.5, 7.8, 7.8, 15.5 μg/mL respectively .

HY-N15117

Polymyxin P1	Structural Classification Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Polymyxin P1 is a lipopeptide antibiotic belonging to the Polymyxin family, and it is a secondary metabolite produced by the rhizosphere bacterium Paenibacillus polymyxa M-1. Polymyxin P1 binds to bacterial outer membrane lipopolysaccharides, permeabilizes cell membranes, and induces dense protrusions on the cell surface of phytopathogenic Erwinia strains. Polymyxin P1 inhibits the growth of phytopathogenic Erwinia amylovora and E. carotovora. Polymyxin P1 can be used for the research of fire blight and soft rot .

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Erwinia carotovora

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