2738-64-9
Chemical Structure
Piericidin A
Synonym(s): AR-054
- CAS No.: 2738-64-9
- Formula:C25H37NO4
- Molecular Weight:415.57
IUPAC Name: 2-((2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraen-1-yl)-5,6-dimethoxy-3-methylpyridin-4-ol
InChIKey: BBLGCDSLCDDALX-LKGBESRRSA-N
SMILES: COC1=C(C(C)=C(N=C1OC)C/C=C(C/C=C/C(C)=C/[C@@H](C)[C@H](/C(C)=C/C)O)\C)O
Biological Activity:
Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity[1][2][2].
The product specifications provided below refer solely to the active content of Piericidin A.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Piericidin A | 99.83% | Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity. The product specifications provided below refer solely to the active content of Piericidin A. |
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-
Similarity Score 0.91
HY-N8337IT-143B -
Similarity Score 0.89
HY-N12223Piericidin B -
Similarity Score 0.85
HY-N147317-Demethylpiericidin A1 -
Similarity Score 0.81
HY-N8336IT-143A -
Similarity Score 0.67
HY-N149933' -Deoxytalopiericidin -
Similarity Score 0.64
HY-N1502613-Hydroxyglucopiericidin A -
Similarity Score 0.46
HY-125458Iromycin A -
Similarity Score 0.44
HY-N89774-O-Methylgrifolic acid -
Similarity Score 0.44
HY-120183Harzianopyridone -
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References
- [1]. Matthias Höllerhage, et al. Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice. PLoS One. 2014 Dec 1;9(12):e113557. [Content Brief]
- [2]. Ji Eun Kang, et al. Efficacies of Quorum Sensing Inhibitors, Piericidin A and Glucopiericidin A, Produced by Streptomyces Xanthocidicus KPP01532 for the Control of Potato Soft Rot Caused by Erwinia Carotovora Subsp. Atroseptica. Microbiol Res. 2016 Mar;184:32-41. [Content Brief]
