536757-16-1
Chemical Structure
Retrocyclin-101
Synonym(s): RC-101
- CAS No.: 536757-16-1
- Formula:C74H130N28O19S6
- Molecular Weight:1908.39
SMILES: O=C1[C@@]2([H])NC([C@@H](NC([C@@]3([H])NC([C@](NC(CNC([C@@H](NC(CNC([C@](NC([C@](NC([C@](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@](N1)([H])[C@@H](C)CC)=O)C(NCC(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)NC([C@H]([C@@H](C)CC)NC(CN)=O)=O)=O)CCCNC(N)=N)=O)([H])CSSC2)=O)([H])[C@@H](C)CC)=O)([H])CSSC3)=O)=O)CCCCN)=O)=O)([H])[C@@H](C)CC)=O)=O)CCCNC(N)=N)=O
Biological Activity: Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression[1][2][3][4][5].
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Retrocyclin-101 | Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression. | |||||||||||||||||||||
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References
- [1]. Kudryashova E, et al. Inhibition of SARS-CoV-2 Infection by Human Defensin HNP1 and Retrocyclin RC-101. J Mol Biol. 2022;434(6):167225. [Content Brief]
- [2]. Jia X, et al. Mechanism through Which Retrocyclin Targets Flavivirus Multiplication. J Virol. 2021;95(15):e0056021. [Content Brief]
- [3]. Lee SB, et al. Expression and characterization of antimicrobial peptides Retrocyclin-101 and Protegrin-1 in chloroplasts to control viral and bacterial infections. Plant Biotechnol J. 2011;9(1):100-115. [Content Brief]
- [4]. Lamers RP, et al. Characterization of the retrocyclin analogue RC-101 as a preventative of Staphylococcus aureus nasal colonization. Antimicrob Agents Chemother. 2011;55(11):5338-5346. [Content Brief]
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[5]. Prantner D, et al. The θ-defensin retrocyclin 101 inhibits TLR4- and TLR2-dependent signaling and protects mice against influenza infection. J Leukoc Biol. 2017 Oct;102(4):1103-1113.
[Content Brief]
