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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
Fzd4
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "Fzd4" in MCE Product Catalog:
2
2 Cited Publications
FzM1.8 is a Wnt/β-catenin signaling pathway agonist and an allosteric agonist of Frizzled 4 (FZD4), with a pEC50 of 6.4 for FZD4 . FzM1.8 stabilizes a conformation with increased affinity for heterotrimeric G proteins, promoting Gβγ release and subsequent PI3K activation. FzM1.8 activates the AKT pathway downstream of FZD4. FzM1.8 does not affect FZD4 maturation or plasma membrane localization and does not induce FZD4 endocytosis. FzM1.8 upregulates the WNT-responsive genes C-myc and Cyclin D1, while leaving lgr5 expression unchanged. FzM1.8 can be used for colon cancer research .
1
1 Cited Publications
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=?6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade .
Cat. No.: HY-RS05180
Target:
Research Areas:
FZD4 Human Pre-designed siRNA Set A contains three designed siRNAs for FZD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23785
Target:
Research Areas:
Fzd4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fzd4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17330
Target:
Research Areas:
Fzd4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fzd4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P992126
CAS No.: 3059389-31-7
Synonyms: EYE-103; MK-3000
Target:
Research Areas:
Remigromig (EYE-103; MK-3000) is a humanized dual-target monoclonal antibody that targets LRP5 and FZD4. Remigromig activates the Wnt/β-catenin signaling pathway by mimicking the natural ligand Norrin, induces tight junction formation and restores blood-retinal barrier function. Administered via intravitreal injection, Remigromig reduces retinal vascular leakage, and demonstrates improvements in best-corrected visual acuity and reductions in retinal thickness in studies of diabetic macular edema. Remigromig can be used for research related to macular degeneration .
Cat. No.: HY-P87422A
Synonyms: CD344, Frizzled-4, Fz-4, hFz4, FzE4, Fzd4
Cat. No.: HY-P74141
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fzd4; Frizzled Homolog 4 (Drosophila); Prev. EVR1; Exudative Vitreoretinopathy 1; CD344; WNT Receptor Frizzled-4; Frizzled 4, Seven Transmembrane Spanning Receptor; Frizzled Homolog 4; Frizzled Family Receptor 4; CD344 Antigen; Frizzled-4; Fzd4S; Fz-4; FE
Species:
Human
Source:
HEK293
Cat. No.: HY-P74142
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fzd4; Frizzled Homolog 4 (Drosophila); Prev. EVR1; Exudative Vitreoretinopathy 1; CD344; WNT Receptor Frizzled-4; Frizzled 4, Seven Transmembrane Spanning Receptor; Frizzled Homolog 4; Frizzled Family Receptor 4; CD344 Antigen; Frizzled-4; Fzd4S; Fz-4; FE
Species:
Rat
Source:
HEK293
Cat. No.: HY-P74143
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fzd4; Frizzled Homolog 4 (Drosophila); Prev. EVR1; Exudative Vitreoretinopathy 1; CD344; WNT Receptor Frizzled-4; Frizzled 4, Seven Transmembrane Spanning Receptor; Frizzled Homolog 4; Frizzled Family Receptor 4; CD344 Antigen; Frizzled-4; Fzd4S; Fz-4; FE
Species:
Rat
Source:
HEK293
Cat. No.: HY-P74140
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Fzd4; Frizzled Homolog 4 (Drosophila); Prev. EVR1; Exudative Vitreoretinopathy 1; CD344; WNT Receptor Frizzled-4; Frizzled 4, Seven Transmembrane Spanning Receptor; Frizzled Homolog 4; Frizzled Family Receptor 4; CD344 Antigen; Frizzled-4; Fzd4S; Fz-4; FE
Species:
Human
Source:
HEK293
Cat. No.: HY-181160
Research Areas:
JNK3/Wnt/β-catenin modulator-1 is a brain-penetrant JNK3 inhibitor and Wnt/β-catenin activator. JNK3/Wnt/β-catenin modulator-1 decreases Aβ1-42 production and reduced ROS generation. JNK3/Wnt/β-catenin modulator-1 inhibits the activation of JNK and Puma, promotes Beclin-1 expression, reduces GSK-3β and BACE1 expression and activates Wnt/β-catenin signaling. JNK3/Wnt/β-catenin modulator-1 improves cognitive and memory performance, attenuates histopathological brain damage, preserves structure of hippocampal pyramidal cells and cerebral cortical neurons. JNK3/Wnt/β-catenin modulator-1 can be used for the research of Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
