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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
GLE1
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "GLE1" in MCE Product Catalog:
Cat. No.: HY-170430
CAS No.: 3055558-98-7
Target:
Research Areas:
HGC652 is a molecular glue degrader targeting TRIM21 with a TRIM21-dependent nuclear membrane disruption effect. HGC652 binds to the PRY-SPRY domain of TRIM21 with high affinity (Ka=0.061 μM), mediates the interaction between TRIM21 and NUP98, and redirects E3 ligase activity. By triggering the polyubiquitination and proteasomal degradation of nucleoporins (such as NUP155 and GLE1), HGC652 disrupts nuclear membrane integrity, alters nuclear morphology, induces genomic instability, and thereby induces cancer cell death [1] .
Cat. No.: HY-RS05470
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Research Areas:
GLE1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-186250
CAS No.: 3055559-33-3
Target:
Research Areas:
TRIM21 ligand-1 is a TRIM21 ligand. TRIM21 ligand-1 mediates the degradation of nuclear pore complex proteins GLE1 and NUP155. TRIM21 ligand-1 induces the disassembly of nuclear pore complexes, which in turn leads to cell death. TRIM21 ligand-1 can be used in cancer research [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
