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Results for "

Hs683

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125848
    Ginsenoside F2

    		Apoptosis AMPK PPAR p38 MAPK PI3K Akt GSK-3 Reactive Oxygen Species (ROS) SOD Caspase Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Ginsenoside F2 is an orally active bioactive compound that participates in the regulation of metabolism and inflammation. Ginsenoside F2 promotes the phosphorylation of AMPK and ACC, binds to PPARγ, inhibits the phosphorylation of MAPK, activates the PI3K/AKT/GSK-3β pathway, reduces GLRX expression, and regulates lipid metabolism. Ginsenoside F2 reduces ROS production and MDA levels, restores SOD activity in cells, and alleviates oxidative stress. Ginsenoside F2 induces cell apoptosis (Apoptosis) and increases the number of cleaved caspase-3-positive cells. Ginsenoside F2 reduces body weight gain, adipose tissue weight and serum lipid levels in obese mice, and activates the hepatic AMPK signaling pathway and the expression of antioxidant enzymes. Ginsenoside F2 alleviates atopic dermatitis in mice by inhibiting inflammation and reshaping the gut microbiota . Ginsenoside F2 is applicable to research related to insulin resistance, obesity, atopic dermatitis, liver cancer, glioblastoma and glioma .
    Ginsenoside F2
  • HY-137052
    Lycorine methiodide

    N-Methyllycorine iodide

    		 Drug Derivative Cancer
    Lycorine methiodide (N-Methyllycorine iodide) is a derivative of Lycorine (HY-N0288). Lycorine methiodide exhibits no significant in vitro antitumor activity against A549, OE21, Hs683, U373, SKMEL, and B16F10 cell lines, with all IC50 values greater than 10 μM .
    Lycorine methiodide
  • HY-N7158
    Elasticamide

    		Others Cancer
    Elasticamide is a natural compound isolated from Ficus elastica Roxb. Elasticamide inhibits the cell growth in the U373n, with the IC50 of 88 μM .
    Elasticamide
  • HY-153509
    Sirtuin-IN-1

    		Sirtuin Cancer
    Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC50s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively). Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma .
    Sirtuin-IN-1
  • HY-126700
    Sphaeropsidin B

    		Endogenous Metabolite Cancer
    Sphaeropsidin B is a pimarane diterpene and phytotoxin. Sphaeropsidin B can be found in Diplodia cupressi and Diplodia corticola. Sphaeropsidin B induces phytotoxic effects in plants. Sphaeropsidin B can be used for the research of plant injury-related research areas .
    Sphaeropsidin B

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