3 Results for "

IWP2

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "IWP2" in MCE Product Catalog:

35
35 Cited Publications
Cat. No.: HY-13912
CAS No.: 686770-61-6
Purity:  99.93%
Research Areas:  

Cancer

IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ [2].
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1
1 Cited Publications
Cat. No.: HY-13912G
CAS No.: 686770-61-6
IWP-2 (GMP) is >IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .
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Cat. No.: HY-121540
CAS No.: 877618-79-6
Target:  

Wnt

Research Areas:  

Cancer

IWP-2-V2 is a IWP-2 (HY-13912) analogue that retains activity against the Wnt/β-catenin pathway .
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