18 Results for "

Kuwanon L

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "Kuwanon L" in MCE Product Catalog:

Cat. No.: HY-N18192
CAS No.: 88524-65-6
Kuwanon L is an HIV-1 integrase (HIV-1 integrase) inhibitor, with IC50 values of 42 μM and 34 μM for LEDGF-dependent and LEDGF-independent integrase, respectively. Kuwanon L blocks the interaction between HIV-1 integrase and LEDGF/p75, with an IC50 of 22 μM. Kuwanon L inhibits HIV-1 replication in immune cells. Kuwanon L is applicable to research related to HIV-1 infection .
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1 Cited Publications
Cat. No.: HY-N4247
CAS No.: 75629-19-5
Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis .
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1 Cited Publications
Cat. No.: HY-N2300
CAS No.: 62949-77-3
Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.
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Cat. No.: HY-N2600
CAS No.: 76472-87-2
Kuwanon H is a selective non-peptide bombesin receptor antagonist and platelet activation inhibitor. Kuwanon H also acts as a specific antagonist of GRP-preferring receptors, with a Ki value of 290 nM for mouse GRP-R and 6500 nM for rat NMB-R. Kuwanon H inhibits the phosphorylation of AKT, mTOR, ERK, cPLA2 and p38, and upregulates TRIB3. It induces endoplasmic reticulum stress, apoptosis and autophagosome formation. Kuwanon H blocks calcium mobilization, mitogenic signaling, DNA synthesis, dense granule secretion, thromboxane A2 generation and integrin αIIb/β3 activity. It inhibits collagen-induced platelet aggregation and fibronectin adhesion, and delays clot retraction. Kuwanon H inhibits melanoma cell growth in vitro and in vivo, and enhances the sensitivity of melanoma cells to CDDP. It can be used in research related to melanoma, small cell lung cancer and thrombosis .
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Cat. No.: HY-N3514
CAS No.: 68401-05-8
Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β .
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Cat. No.: HY-N4247R
CAS No.: 75629-19-5
Kuwanon G (Standard) is the analytical standard of Kuwanon G (HY-N4247). This product is intended for research and analytical applications. Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis .
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Cat. No.: HY-N16130
CAS No.: 100187-67-5
Kuwanon S is a flavonoid compound that can be isolated from the root bark of Morus alba L. Kuwanon S is commonly used in organic synthesis and biochemistry experiments .
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Cat. No.: HY-N12581
CAS No.: 123702-95-4
Kuwanon U is a potent cholinesterase inhibitor with IC50s of 19.69, 10.11 µM and Kis of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD) .
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Cat. No.: HY-N11531
CAS No.: 95518-95-9
Kuwanon W is a natural product that can be isolated from the root bark of Morus lhou .
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Cat. No.: HY-N2600R
CAS No.: 76472-87-2
Kuwanon H (Standard) is the analytical standard of Kuwanon H. This product is intended for research and analytical applications. Kuwanon H is a selective non-peptide bombesin receptor antagonist and platelet activation inhibitor. Kuwanon H also acts as a specific antagonist of GRP-preferring receptors, with a Ki value of 290 nM for mouse GRP-R and 6500 nM for rat NMB-R. Kuwanon H inhibits the phosphorylation of AKT, mTOR, ERK, cPLA2 and p38, and upregulates TRIB3. It induces endoplasmic reticulum stress, apoptosis and autophagosome formation. Kuwanon H blocks calcium mobilization, mitogenic signaling, DNA synthesis, dense granule secretion, thromboxane A2 generation and integrin αIIb/β3 activity. It inhibits collagen-induced platelet aggregation and fibronectin adhesion, and delays clot retraction. Kuwanon H inhibits melanoma cell growth in vitro and in vivo, and enhances the sensitivity of melanoma cells to CDDP. It can be used in research related to melanoma, small cell lung cancer and thrombosis .
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Cat. No.: HY-N10375
CAS No.: 100187-66-4
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Kuwanon T is an isoprenylated flavonoid compound isolated from the root bark of Morus alba. Kuwanon T shows protective effects on t-BHP-induced oxidative stress with a EC50 of 30.32 μM .
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Cat. No.: HY-N11463
CAS No.: 88524-66-7
Kuwanon K is a natural product that can be isolated from Morus Lhou .
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Cat. No.: HY-N8783
CAS No.: 62949-78-4
Kuwanon B is a flavone derivative that can be found in the root bark of the cultivated mulberry tree (a variety of Morus alba L.) .
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Cat. No.: HY-N18065
CAS No.: 105016-28-2
Kuwanon Y is a Diels-Alder type adduct with antioxidant activity. Kuwanon Y is present in the stem bark of Morus macroura Miq .
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Cat. No.: HY-N21559
CAS No.: 67172-84-3
Kuwanon D is a prenylated flavanone found in the root bark of Morus alba L. Kuwanon D is predicted to be a high-affinity binder of SARS-CoV-2 main protease (Mpro), with favorable bioavailability and compliance with Lipinski's Rule of Five. Kuwanon D is an active component of Morus alba root bark identified as a lung cancer-related gene-targeting compound through network pharmacology screening. Kuwanon D is applicable to research related to COVID-19 and lung cancer .
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Cat. No.: HY-N16795
CAS No.: 71344-07-5
Kuwanon F is a natural flavonoid.
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Cat. No.: HY-N21975
CAS No.: 89200-02-2
Kuwanon N is a naturally occurring flavonoid derivative and Diels-Alder adduct isolated from the root bark of Morus lhou Koidz. Kuwanon N is applicable to studies on natural Diels-Alder adducts and flavonoid natural products .
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Cat. No.: HY-N11464
CAS No.: 89200-01-1
Kuwanon O is a flavonoid derivative with a fused dihydrochalcone partial moiety, that can be isolated from the root bark of Morus lhou (set.) Koidz .
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