Kuwanon L
Kuwanon L is an HIV-1 integrase (HIV-1 integrase) inhibitor, with IC50 values of 42 μM and 34 μM for LEDGF-dependent and LEDGF-independent integrase, respectively. Kuwanon L blocks the interaction between HIV-1 integrase and LEDGF/p75, with an IC50 of 22 μM. Kuwanon L inhibits HIV-1 replication in immune cells. Kuwanon L is applicable to research related to HIV-1 infection.
For research use only. We do not sell to patients.
- CAS No.: 88524-65-6
- Formula: C35H30O11
- Molecular Weight:626.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-3 | CC50 |
97.7 μM
Compound: 16
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Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability
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[PMID: 36651644] |
Kuwanon-L (6.4-20000 nM; 1 h virus pretreatment, 48 h cell incubation) inhibits HIV-1 NL4.3 replication in human TZM-bl indicator cells with an EC50 of 1.9 μM, and shows no cytotoxicity at concentrations up to 20 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 88524-65-6
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Molecular Weight 626.61
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Formula C35H30O11
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SMILES
O=C(C1=C(C=C(C=C1)O)O)[C@@H]2[C@@H](C3=C(C([C@H]4OC5=CC(O)=CC(O)=C5C(C4)=O)=CC=C3O)O)C=C(C[C@H]2C6=C(C=C(C=C6)O)O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kuwanon L Related Classifications
HY-N18192 Related Classifications
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