Kuwanon L

Cat. No.: HY-N18192: Data Sheet Handling Instructions
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Kuwanon L is an HIV-1 integrase (HIV-1 integrase) inhibitor, with IC₅₀ values of 42 μM and 34 μM for LEDGF-dependent and LEDGF-independent integrase, respectively. Kuwanon L blocks the interaction between HIV-1 integrase and LEDGF/p75, with an IC₅₀ of 22 μM. Kuwanon L inhibits HIV-1 replication in immune cells. Kuwanon L is applicable to research related to HIV-1 infection.

For research use only. We do not sell to patients.

Kuwanon L Chemical Structure

CAS No. : 88524-65-6

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

HIV-1

In Vitro

Kuwanon-L (6.4-20000 nM; 1 h virus pretreatment, 48 h cell incubation) inhibits HIV-1 NL4.3 replication in human TZM-bl indicator cells with an EC₅₀ of 1.9 μM, and shows no cytotoxicity at concentrations up to 20 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

626.61

Formula

C₃₅H₃₀O₁₁

CAS No.

88524-65-6

SMILES

O=C(C1=C(C=C(C=C1)O)O)[C@@H]2[C@@H](C3=C(C([C@H]4OC5=CC(O)=CC(O)=C5C(C4)=O)=CC=C3O)O)C=C(C[C@H]2C6=C(C=C(C=C6)O)O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Esposito F, et al. Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation. Chembiochem. 2015;16(17):2507-2512. [Content Brief]

Kuwanon L Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kuwanon L88524-65-6HIVHIV IntegraseHuman immunodeficiency virusHIV-1 replicationLEDGIN binding pocketHIV-1 integraseCOX-2HIV-1 infectionhuman TZM-bl indicator cellsHIV-1 integrase CCD dimerimmune cellsLEDGF/p75sucrose binding pocketInhibitorinhibitorinhibit

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