7 Results for "

LRIG1

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "LRIG1" in MCE Product Catalog:

Cat. No.: HY-RS07787
Research Areas:  

Others

LRIG1 Human Pre-designed siRNA Set A contains three designed siRNAs for LRIG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS25704
Research Areas:  

Others

Lrig1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lrig1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS19215
Research Areas:  

Others

Lrig1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lrig1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P77988
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LIG-1; LIG1; LRIG1; D6Bwg0781e; Img
Species:  
Source:  
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Cat. No.: HY-P701019
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LIG-1; LIG1; LRIG1; D6Bwg0781e; Img
Species:  
Source:  
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Cat. No.: HY-P70398
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rMuLeucine-rich repeats and immunoglobulin-like domains protein 1/LRIG1, His; Leucine-rich repeats and immunoglobulin-like domains protein 1; LIG-1; LRIG1
Species:  
Source:  
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Cat. No.: HY-P992369

Target:  

VISTA

Research Areas:  

Cancer

HMBD-002 is an Fc-independent, non-depleting IgG4 subclass antibody that targets VISTA and VSIG3. It is widely used in research related to various solid tumors, including colon cancer, triple-negative breast cancer, and non-small cell lung cancer. HMBD-002 blocks the interactions of VISTA with VSIG3 and LRIG1, relieves immunosuppression without depleting VISTA-positive cells, activates the cytotoxic program of CD8 + T cells, and drives the type I interferon signaling pathway. HMBD-002 reprograms tumor-associated macrophages to the M1 phenotype, reduces tumor infiltration of inhibitory myeloid cells, thereby significantly inhibiting tumor growth and improving survival. HMBD-002 is well tolerated in rodent and non-human primate animal models [1] .
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