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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
122 Results for "
M2 protein
" in MedChemExpress (MCE) Product Catalog:
Products (122)
122 Results for "M2 protein" in MCE Product Catalog:
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10 Publications Verification
Cat. No.: HY-19959
CAS No.: 1198097-97-0
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells .
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7 Cited Publications
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Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .
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Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis .
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2 Cited Publications
Cat. No.: HY-P71676
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DLAT; E2 Component Of Pyruvate Dehydrogenase Complex; Prev. DLTA; M2 Antigen Complex 70 KDa Subunit; PDC-E2; PDCE2; Dihydrolipoyllysine-Residue Acetyltransferase Component Of Pyruvate Dehydrogenase Complex, Mitochondrial; PBC; Dihydrolipoamide Acetyltrans
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2 Cited Publications
Cat. No.: HY-P80870
Synonyms: PKM; OIP3; PK2; PK3; PKM2; Pyruvate kinase isozymes M1/M2; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tu
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Rimantadine (1-Rimantadine) is an orally active inhibitor for M2 protein, which blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity. Rimantadine significantly inhibits hepatitis A virus (HAV) replication at the post-entry stage in Huh7 cells. Rimantadine enhances autophagy. Rimantadine has a significant protective effect against H3N2 virus in mouse model .
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Rimantadine hydrochloride (Flumadine hydrochloride) is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity .
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1 Cited Publications
Cat. No.: HY-160799
CAS No.: 2412367-83-8
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HA-9104 is a potent and selective inhibitor of cullin-5 neddylation via virtually targeting the V30 pocket of UBE2F. HA-9104 binds to UBE2F, reduces its protein levels, and consequently inhibits cullin-5 neddylation. HA-9104 has potent growth suppression and radiosensitizing activities via targeting the UBE2F-CRL5 axis and causing DNA damage, leading to induction of apoptosis and G2/M arrest in lung and pancreatic cancer cells .
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Flavonols Flavonoids Myrtaceae Phenols Polyphenols Plants Disease Research Fields Syzygium aromaticum Cancer
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BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu .
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Quinones Monophenols Anthraquinones Rubiaceae Metabolic Disease Phenols Plants Disease Research Fields Rubia cordifolia L.
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1 Cited Publications
INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G2-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway .
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1 Cited Publications
Cat. No.: HY-P1783A
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1 Cited Publications
Cat. No.: HY-P1376A
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1 Cited Publications
Cat. No.: HY-P75152A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GSTM2; Glutathione S-Alkyltransferase M2; Glutathione S-Transferase Mu 2; Glutathione S-Aryltransferase M2; GST4; Glutathione S-Transferase M1; Glutathione S-Transferase Mu 2 (Muscle); Glutathione S-Transferase 4; Glutathione S-Transferase M2 (Muscle); Gl
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1 Cited Publications
Cat. No.: HY-P7803
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PKM; Tumor M2-PK; Prev. PKM2; P58; THBP1; Thyroid Hormone-Binding protein, Cytosolic; OIP3; Epididymis Secretory protein Li 30; PK3; Pyruvate Kinase Isozymes M1/M2; Pyruvate Kinase Muscle Isozyme; OPA-Interacting protein 3; Cytosolic Thyroid Hormone-Bindi
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1 Cited Publications
Cat. No.: HY-172158
CAS No.: 140481-05-6
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ALKBH5-IN-5 is a highly selective ALKBH5 (IC50 = 0.62 μM, Kd = 804 nM). ALKBH5-IN-5 disrupts ALKBH5 binding to m 6A-RNA and 6mA-DNA substrates. ALKBH5-IN-5 promotes differentiation, induces apoptosis, cause G2-M phase arrest and exerts strong antiproliferative effects in cancer cells. ALKBH5-IN-5 reduces TACC3 and MYC protein levels and increases cleaved caspase-3 levels. ALKBH5-IN-5 exerts antitumor activity in tumor xenograft mice models. ALKBH5-IN-5 can be used for the research of acute myeloid leukemia .
KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells .
Cat. No.: HY-W009141
CAS No.: 542-44-9
Synonyms: Glyceryl palmitate
Cat. No.: HY-N2416
CAS No.: 108885-68-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
