300809-71-6
300809-71-6
Chemical Structure
KRAS inhibitor-9
- CAS No.: 300809-71-6
- Formula:C13H9ClN2S2
- Molecular Weight:292.81
IUPAC Name: 4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline
InChIKey: DTSNLMOLTVGCGZ-UHFFFAOYSA-N
SMILES: NC1=CC=C(SC2=NC3=CC=CC=C3S2)C(Cl)=C1
Biological Activity: KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1].
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KRAS inhibitor-9 | 99.85% | KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells. | ||||||||||||||||||||
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