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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
MERS-CoV main protease
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "MERS-CoV main protease" in MCE Product Catalog:
Cat. No.: HY-121020
CAS No.: 83162-82-7
Target:
Cat. No.: HY-151991
CAS No.: 3034217-02-9
SARS-CoV-2/MERS Mpro-IN-2 (compound 9d) is a potent SARS-CoV-2 and MERS main protease inhibitor with IC50 values of 0.21, 0.07 µM, respectively .
Cat. No.: HY-187507
Target:
Research Areas:
AVI8122 is a covalent coronavirus main protease (M pro) inhibitor, with IC50 values of 0.0047 μM, 0.065 μM, 0.04 μM, 0.004 μM, 0.027 μM and 0.020 μM against SARS-CoV-2, MERS-CoV, HKU8, PEDV, IBV and HKU15, respectively; it exhibits Ki values of 0.14 nM, 1.8 nM, 0.9 nM, 0.2 nM and 5.2 nM against SARS-CoV-2, HKU8, PEDV, IBV and HKU15, respectively. AVI8122 forms a covalent hemithioacetal bond with the catalytic cysteine of M pro, blocks its proteolytic activity, and acts on the four coronavirus genera α, β, γ and δ. AVI8122 is applicable to research related to SARS-CoV-2 infection .\n
Cat. No.: HY-170894
SARS-CoV-2 Mpro-IN-37 (compound 8r) is a SARS-CoV-2 main protease (M pro) inhibitor, with an IC50 of 0.0199 μM. SARS-CoV-2 Mpro-IN-37 inhibits SARS-CoV-1 M pro and MERS-CoV M pro with IC50s of 0.00945 and 0.111 μM, respectively. SARS-CoV-2 Mpro-IN-37 displays high antiviral activity in the nanomolar range without showing cellular toxicity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
