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Results for "

Makino

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

18

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108943
    Sabinene
    2 Publications Verification

    		 Others Others
    Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways .
    Sabinene
  • HY-N6028
    Darutoside
    1 Publications Verification

    		 COX NF-κB Interleukin Related TNF Receptor Inflammation/Immunology
    Darutoside is an orally effective diterpene compound with significant anti-inflammatory, analgesic, wound healing promotion, and immunomodulatory activities. Darutoside reduces edema and pain responses by inhibiting the expression of COX-2 and the migration of inflammatory cells. It regulates macrophage polarization towards the M2 type by inhibiting the NF-κB pathway, alleviating inflammation and promoting wound healing. Through multi-target regulation of metabolic networks, Darutoside significantly alleviates acute gouty arthritis .
    Darutoside
  • HY-N6901
    Luteolin 7-sulfate

    		Epigenetic Reader Domain Metabolic Disease
    Luteolin 7-sulfate is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis .
    Luteolin 7-sulfate
  • HY-N3364
    Lucidone

    		Flavivirus Dengue Virus TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK Infection Inflammation/Immunology
    Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM) .
    Lucidone
  • HY-N9540
    Methyl citrate

    		Monoamine Oxidase Neurological Disease
    Methyl citrate is a Monoamine oxidase B (MAO-B) inhibitor (IC50=0.23 mM). Methyl citrate is isolated from the fruits of Opuntia ficus-indica var. saboten Makino .
    Methyl citrate
  • HY-N3260
    Methyllucidone

    		Reactive Oxygen Species (ROS) Keap1-Nrf2 PI3K Inflammation/Immunology
    Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino. Methyllucidone inhibits the ROS production, and activates antioxidant signaling pathways that include Nrf-2 and PI3K .
    Methyllucidone
  • HY-N3106
    Pashanone

    		Others Others
    Pashanone is a compound isolated from Lindera erytbrocarpa Makino (Lauraceae) .
    Pashanone
  • HY-N1281
    Sendanolactone

    		Others Others
    Sendanolactone is a new tetracyclic triterpenoid from the bark of M. azedarach L. var. japonica Makino .
    Sendanolactone
  • HY-N3150
    Ohchinin acetate

    		Others Others
    Ohchinin acetate is a limonoid, that can be isolated from the fruit of M. azedarach Linn. var. japonica Makino .
    Ohchinin acetate
  • HY-18399A
    YM-1 TFA

    		Angiotensin-converting Enzyme (ACE) Others
    YM-1 (TFA) is an inhibitor of angiotensin converting enzyme (ACE) that can be obtained from Chrysanthemum boreale Makino .
    YM-1 TFA
  • HY-N12133
    4,7-Didehydroneophysalin B

    		Others Metabolic Disease
    4,7-Didehydroneophysalin B is a steroid compound. 4,7-Didehydroneophysalin B can be isolated and purified from the natural Physalis alkekengi L. var. franchetii (Mast.) Makino.
    4,7-Didehydroneophysalin B
  • HY-N4282
    8-Hydroxy-7-methoxycoumarin

    		Others Cancer
    8-Hydroxy-7-methoxycoumarin is a phenylpropanoid isolated from the calyxes of Physalis alkekengi L. var. franchetii (Mast.) Makino. 8-Hydroxy-7-methoxycoumarin shows cytotoxicity against GLC4 and COLO 320 cancer cell after continuous incubation (4 days) with IC50s of 179 μM and 145 μM .
    8-Hydroxy-7-methoxycoumarin
  • HY-N18018
    Tetrahydroswertianolin

    		Drug Derivative Metabolic Disease Inflammation/Immunology
    Tetrahydroswertianolin (Compound 1) is a tetrahydroxyxanthone glycoside that can be isolated from the whole plant of Swertia japonica Makino. Tetrahydroswertianolin reduces the elevated blood ALT levels in mice with immune-induced liver injury and exhibits protective activity against liver injury. Tetrahydroswertianolin can be used in studies related to anthelmintic, antipyretic and immune-induced liver injury .
    Tetrahydroswertianolin
  • HY-N17994
    GypenosideZ-2

    		Drug Derivative Others
    GypenosideZ-2 is a dammarane-type triterpene saponin found in the aerial parts of Gynostemma pentaphyllum (Thunb.) Makino .
    GypenosideZ-2
  • HY-N8782
    4,6,7-Trimethoxy-5-methylcoumarin

    		Others Others
    4,6,7-Trimethoxy-5-methylcoumarin is a Coumarins product that can be isolated from the herbs of Viola yedonensis Makino .
    4,6,7-Trimethoxy-5-methylcoumarin
  • HY-W401797
    5-Hydroxy-6,7,8-trimethoxycoumarin

    		Others Others
    5-Hydroxy-6,7,8-trimethoxycoumarin is a Coumarins product that can be isolated from the herbs of Viola yedonensis Makino .
    5-Hydroxy-6,7,8-trimethoxycoumarin
  • HY-N18019
    Tetrahydro bellidifolin

    		Drug Metabolite Metabolic Disease
    Tetrahydro bellidifolin (Compound 1a) is the aglycone obtained from the hydrolysis of Tetrahydroswertianolin (HY-N18018) by β-glucosidase. Tetrahydro bellidifolin exhibits significant hepatoprotective activity and reduce serum ALT levels. Tetrahydro bellidifolin can be used for the research of liver injury .
    Tetrahydro bellidifolin
  • HY-N15140
    α-Thujaplicin

    		Drug Isomer Bacterial Fungal Carboxypeptidase Infection Cancer
    α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma .
    α-Thujaplicin
  • HY-N17495
    Luteolin 7-O-(6-O-malonyl-β-D-glucoside)

    		Others Metabolic Disease
    Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is an orally active flavonoid free radical scavenger. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) scavenges free radicals, inhibits the activity elevation of aspartate aminotransferase and alanine aminotransferase in mouse plasma, as well as the elevation of liver lipid hydroperoxide content. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is applicable for liver injury research .
    Luteolin 7-O-(6-O-malonyl-β-D-glucoside)

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