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  4. Sabinene

Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways.

For research use only. We do not sell to patients.

Sabinene Chemical Structure

Sabinene Chemical Structure

CAS No. : 3387-41-5

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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USD 73 In-stock
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10 mM * 1 mL in DMSO USD 73 In-stock
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100 mg USD 66 In-stock
500 mg USD 132 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Sabinene

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways[1][2].

In Vitro

Sabinene (10-300 μM; 18 h) induces predominant recovery of reductions of myotube diameters under starvation[2].
Sabinene (300 μM; 18 h) diminishes the elevated E3 ubiquitin ligase muscle ring-finger protein-1 (MuRF-1) expression and p38 mitogen-activated protein kinase (MAPK), and attenuates extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylations in starved myotubes[2].
Sabinene (300 μM; 18 h) decreases the increased level of reactive oxygen species (ROS) in myotubes under starvation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: IL-6 myoblasts
Concentration: 300 μM
Incubation Time: 18 and 48 hours
Result: Failed to affect the viability of IL-6 myoblasts after 48 h incubation and recovered more than 50% of starvation-induced myoblast atrophy after 18 h.

Western Blot Analysis[2]

Cell Line: IL-6 myoblasts
Concentration: 300 μM
Incubation Time: 18 hours
Result: Attenuated muscle atrophy-related signaling proteins phosphorylation in starved myotubes.
In Vivo

Sabinene (6.4 mg/kg; p.o.; once daily; during the fasting for 2 d) attenuates skeletal muscle atrophy by regulating the activation mechanism of ROS-mediated MAPK/MuRF-1 pathways in starved myotubes, probably leading to the reverse of reduced muscle fiber size in fasted rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fasted animal model in rat[2]
Dosage: 6.4 mg/kg
Administration: Oral gavage; once daily; during the fasting for 2 days
Result: Reduced the levels of muscle fiber atrophy and MuRF-1 expression in gastrocnemius from fasted rats.
Molecular Weight

136.23

Formula

C10H16

CAS No.
Unlabeled CAS

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC(C12CCC(C1C2)=C)C

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (244.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.3405 mL 36.7026 mL 73.4053 mL
5 mM 1.4681 mL 7.3405 mL 14.6811 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.3405 mL 36.7026 mL 73.4053 mL 183.5132 mL
5 mM 1.4681 mL 7.3405 mL 14.6811 mL 36.7026 mL
10 mM 0.7341 mL 3.6703 mL 7.3405 mL 18.3513 mL
15 mM 0.4894 mL 2.4468 mL 4.8937 mL 12.2342 mL
20 mM 0.3670 mL 1.8351 mL 3.6703 mL 9.1757 mL
25 mM 0.2936 mL 1.4681 mL 2.9362 mL 7.3405 mL
30 mM 0.2447 mL 1.2234 mL 2.4468 mL 6.1171 mL
40 mM 0.1835 mL 0.9176 mL 1.8351 mL 4.5878 mL
50 mM 0.1468 mL 0.7341 mL 1.4681 mL 3.6703 mL
60 mM 0.1223 mL 0.6117 mL 1.2234 mL 3.0586 mL
80 mM 0.0918 mL 0.4588 mL 0.9176 mL 2.2939 mL
100 mM 0.0734 mL 0.3670 mL 0.7341 mL 1.8351 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Sabinene
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